Centers & Labs

RIKEN Quantitative Biology Center

Laboratory for Reconstitutive Developmental Biology

Unit Leader: Miki Ebisuya (Ph.D.)
Miki  Ebisuya(Ph.D.)

Our research interests are in cell-cell communications that occur during development of multicellular organisms. The cells communicate with each other to autonomously differentiate into different cell types and to form spatial patterns in a variety of tissues. To understand the mechanisms, we have been reconstituting the cell-cell communications by constructing artificial gene networks in cultured cells.

Main Research Field

Biology & Biochemistry

Related Research Fields

Physics / Engineering / Molecular Biology & Genetics / Multidisciplinary

Research Subjects

  • Reconstitution of cell autonomous differentiation
  • Reconstitution of cell pattern formation
  • Reconstitution of tissue deformation

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.
  1. Matsuda, M., Koga, M., Woltjen, K., Nishida, E. & Ebisuya, M.:
    "Synthetic lateral inhibition governs cell-type bifurcation with robust ratios"
    Nat. Commun. 6, 6195 (2015)
  2. Imajo, M., Ebisuya, M. & Nishida, E.:
    "Dual role of YAP and TAZ in renewal of the intestinal epithelium"
    Nat. Cell Biol. 17, 7-19 (2015)
  3. Koga, M., Matsuda, M., Kawamura, T., Sogo, T., Shigeno, A., et al.:
    "Foxd1 is a mediator and indicator of the cell reprogramming process"
    Nat. Commun. 5, 3197 (2014)
  4. *Takashima, S., Hirose, M., Ogonuki, N., Ebisuya, M., Inoue, K., et al.:
    "Regulation of pluripotency in male germline stem cells by Dmrt1"
    Genes & Development 27, 1949-1958 (2013)
  5. *Matsuda, M., Koga, M., Nishida, E. & Ebisuya, M.:
    "Synthetic Signal Propagation Through Direct Cell-Cell Interaction"
    Sci. Signal. 5, ra31 (2012)
  6. *Matsumura, S., Hamasaki, M., Yamamoto, T., Ebisuya, M., Sato, M., et al.:
    "ABL1 regulates spindle orientation in adherent cells and mammalian skin"
    Nat. Commun. 3, 626 (2012)
  7. *Sunadome, K., Yamamoto, T., Ebisuya, M., Kondoh, K., Sehara-Fujisawa, A. & Nishida, E.:
    "ERK5 Regulates Muscle Cell Fusion through Klf Transcription Factors"
    Dev. Cell 20, 192-205 (2011)
  8. *Mitsushima, M., Aoki, K., Ebisuya, M., Matsumura, S., Yamamoto, T., et al.:
    "Revolving movement of a dynamic cluster of actin filaments during mitosis"
    J. Cell Biol. 191, 453-462 (2010)
  9. *Ebisuya, M., Yamamoto, T., Nakajima, M. & Nishida, E.:
    "Ripples from neighbouring transcription"
    Nat. Cell Biol. 10, 1106-1113 (2008)
  10. *Yamamoto, T*., Ebisuya, M*., Ashida, F., Okamoto, K., Yonehara, S. & Nishida, E. (*Equal first authors):
    "Continuous ERK activation downregulates anti proliferative genes throughout G1 phase to allow cell-cycle progression"
    Current biology 16, 1171-1182 (2006)

Lab Members

Principal Investigator

Miki Ebisuya
Unit Leader

Core Members

Mami Takayama
Research Scientist
Mitsuhiro Matsuda
Special Postdoctoral Researcher
Ryoji Sekine
Special Postdoctoral Researcher
Nuria Taberner Carretero
Postdoctoral Researcher
Yuko Sakaide
Technical Staff I

Contact information

2-2-3 Minatojima-minamimachi, Chuo-ku
Kobe, Hyogo
650-0047 Japan

Email: miki.ebisuya [at]

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