Centers & Labs

RIKEN Quantitative Biology Center

Laboratory for Single Cell Gene Dynamics

Unit Leader: Yuichi Taniguchi (Ph.D.)
Yuichi  Taniguchi(Ph.D.)

We are a group of scientists pursuing systems-level biology of single cells. We aim to develop new innovative technologies for comprehensive and exhaustive quantification of single cells that are consists of vast kinds of machinery such as DNA, gene expression products and chemicals. In parallel, utilizing recent advanced technologies, we challenge to analyze dynamic and systematic properties of single cells in a process of a variety of biological phenomena such as cell differentiation. In the end, we aim to find a general concept to understand complex cellular systems from a molecular basis.

Main Research Field

Biological Sciences

Related Research Fields

Interdisciplinary science and engineering


  • Single cell analysis
  • Single molecule and super resolution microscopy
  • Genome structure
  • Central dogma
  • System wide analysis

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.
  1. Taniguchi, Y.:
    "Genome-Wide Analysis of Protein and mRNA Copy Numbers in Single Escherichia coli Cells with Single-Molecule Sensitivity"
    Methods Mol. Biol. 1346, 55-67 (2015)
  2. Ohno, M., Karagiannis, P. & Taniguchi, Y.:
    "Protein Expression Analyses at the Single Cell Level"
    Molecules 19, 13932-13947 (2014)
  3. *Taniguchi, Y., Choi, P. J., Li, G., Chen, H., Babu, M., et al.:
    "Quantifying E-coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells"
    Science 329, 533-538 (2010)
  4. *Taniguchi, Y., Nishiyama, M., Ishii, Y. & Yanagida, T.:
    "Entropy rectifies the Brownian steps of kinesin."
    Nature Chem. Biol. 1, 342-347 (2005)

Lab Members

Principal Investigator

Yuichi Taniguchi
Unit Leader

Core Members

Yamato Yoshida
Research Scientist
David Priest
Foreign Postdoctoral Researcher
Masae Johmura
Postdoctoral Researcher
Simon Leclerc
International Program Associate
Vipin Kumar
International Program Associate
Mayumi Ishida
Technical Staff I

Contact information

6-2-3, Furuedai
Suita, Osaka
565-0874 JAPAN

Email: taniguchi [at]

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