Centers & Labs

Compass to Healthy Life Research Complex Program

System Analysis Team

Team Leader: Hiroo Iwata (D.Eng.)
Hiroo  Iwata(D.Eng.)

Many elderly people are using health foods and supplements in order to extend their healthy life span. However, there are some whose effectiveness is not scientifically proven. Animal experiments have been used to demonstrate effectiveness in the past, but in recent years it has become difficult to evaluate using experimental animals from the viewpoint of animal welfare. In our group, using the knowledge of the biomaterial development and the induction of differentiation of functional cells from human iPS cells, we will prepare evaluation systems (Organs on a chip) for ingredients contained in health foods, cosmetics and supplements.

Main Research Field

Complex systems

Related Research Fields

Chemistry / Biological Sciences / Medicine, dentistry, and pharmacy


  • Biomedical Engineering
  • Biomaterials
  • Transplantation
  • Regenerative medicine
  • Polymer chemistry

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.
  1. *Hirano K, Konagaya S, Turner A, Noda Y, Kitamura S, Kotera H, Iwata H.
    "Closed-channel culture system for efficient and reproducible differentiation of human pluripotent stem cells into islet cells."
    Biochem Biophys Res Commun. (2017) May 27;487(2):344-350. doi: 10.1016/j.bbrc.2017.04.062.
  2. *Konagaya S, Iwata H.
    "Reproducible preparation of spheroids of pancreatic hormone positive cells from human iPS cells: An in vitro study."
    Biochim Biophys Acta. (2016) Sep;1860(9):2008-16. doi: 10.1016/j.bbagen.2016.05.012.
  3. *Konagaya S, Ando T, Yamauchi T, Suemori H, Iwata H.
    "Long-term maintenance of human induced pluripotent stem cells by automated cell culture system."
    Sci Rep. 2015 Nov 17;5:16647. doi: 10.1038/srep16647.
  4. *Itagaki T, Arima Y, Kuwabara R, Kitamura N, Iwata H.
    "Interaction between cells and poly(ethylene glycol)-lipid conjugates."
    Colloids Surf B Biointerfaces. (2015) Nov 1;135:765-73. doi: 10.1016/j.colsurfb.2015.08.014.
  5. *Arima Y, Iwata H.
    "Preferential adsorption of cell adhesive proteins from complex media on self-assembled monolayers and its effect on subsequent cell adhesion."
    Acta Biomater. (2015) Oct;26:72-81. doi: 10.1016/j.actbio.2015.08.033.
  6. *Egawa EY, Kitamura N, Nakai R, Arima Y, Iwata H.
    "A DNA hybridization system for labeling of neural stem cells with SPIO nanoparticles for MRI monitoring post-transplantation."
    Biomaterials. (2015) Jun;54:158-67. doi: 10.1016/j.biomaterials.2015.03.017.
  7. *Hoffecker IT, Takemoto N, Arima Y, Iwata H.
    "Sequence-specific nuclease-mediated release of cells tethered by oligonucleotide phospholipids."
    Biomaterials. (2015);53:318-29. doi: 10.1016/j.biomaterials.2015.02.059.
  8. *Takemoto N, Konagaya S, Kuwabara R, Iwata H.
    "Coaggregates of Regulatory T Cells and Islet Cells Allow Long-term Graft Survival in Liver Without Immunosuppression."
    Transplantation. (2015) May;99(5):942-7. doi: 10.1097/TP.0000000000000579.
  9. *Matsui T, Arima Y, Takemoto N, Iwata H.
    "Cell patterning on polylactic acid through surface-tethered oligonucleotides."
    Acta Biomater. (2015) Feb;13:32-41. doi: 10.1016/j.actbio.2014.11.011.
  10. *Luan NM, Iwata H.
    "Long-term allogeneic islet graft survival in prevascularized subcutaneous sites without immunosuppressive treatment."
    Am J Transplant. (2014) Jul;14(7):1533-42. doi: 10.1111/ajt.12739.

Lab Members

Principal Investigator

Hiroo Iwata
Team Leader

Core Members

Osamu Kurosawa
Deputy Team Leader
Zhuosi Li
Research Scientist
Takeshi Hori
Research Scientist
Hiromi Ito
Technical Staff I
Shintaroh Iwanaga
Visiting Scientist
Ryuji Yokokawa
Visiting Scientist

Contact information

Integrated Innovation Building 6F
6-7-1 Minatojima-minamimachi, Chuo-ku
Kobe, Hyogo
650-0047 Japan
Tel: +81-(0)78-569-8872