Centers & Labs

RIKEN Innovation Center

Benno Laboratory

Head of Benno Laboratory: Yoshimi Benno (D.V.M., Ph.D.)
Yoshimi  Benno(D.V.M., Ph.D.)

Seventy percentages of the human gut bacteria is uncultured. By using new culture method devised, some uncultured isolates are performed the microbial systematic classification. Then, new investigated kits of the human gut bacteria are developed. Effects of functional food, probiotics and prebiotics on human gut bacteria are demonstrated by using the new investigated kits.

Main Research Field

Biological Sciences

Related Research Fields

Complex systems / Biological Sciences / Medicine, dentistry, and pharmacy


  • Gut Microbiota
  • Anaerobes
  • Gut Microbiota

Selected Publications

  1. Kibe R., Kurihara S., Sakai Y., Suzuki H., Ooga T., Sawaki E., Muramatsu K., Nakamura A., Yama-shita A., Kitada Y., Kakeyama M., Benno Y., and Matsumoto M.:
    “Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice”
    Sci. Report 4, 4548 (2014)
  2. Goto Y., Obata T., Kunisawa J., Sato S., Ivanov I., Akiyama Y., Lamlchhance A., Sakamoto M.,
    Matsuki T., Setoyama H., Imaoka A., Uematsu S., Akira S., Domino S.E., Kullg P., Renauld J.-C., Yamamoto M., Sasakawa C., Umesaki Y., Benno Y., and Kiyono H.:
    “Innate lymphoid cells integrate Intestinal epithelial cell glycosylation”
    Science 345(6202), 1254009 (2014)
  3. Sakamoto M., Tanaka Y., Benno Y., and Ohkuma M.:
    Butyricimonas faecihominis sp. nov., and Butyricimonas paravirosa sp. nov., isolated from human faeces, and emended description of the genus Butyricimonas
    Int. J. Syst. Microbiol. 64, 2992-2997 (2014)
  4. Jin J. -S., Touyama M., Yamada S., Yamazaki. T.., and Benno Y.:
    “Alteration of a human intestinal microbiota under extreme life environment in the Antarctica”
    Biol.: Pharm. Bull. 37, 1899-1906 (2014)
  5. Tanaka Y. and Benno Y.:
    “Application of single-colony coculture technique to the isolation of hitherto unculturable gut bacteria”
    Microbiol. Immunol. 59, 63-70 (2015)
  6. Shimizu H. and Benno Y.:
    “Membrane filter method to study the effects of Lactobacillus acidophilus and Bifidobacterium longum on fecal microbiota”
    Microbiol. Immunol. 59, 643-652 (2015)
  7. Touyama M., Jin J. -S., Kibe, R., Hayashi H., and Benno Y.:
    “Quantification of Blautia wexlerae and Blautia luti in human feces by real-time PCR using specific primers”
    Benef. Microbes. 6, 583-90 (2015)
  8. Sakamoto M, Tanaka Y, Benno Y, Ohkuma M.
    Parabacteroides faecis sp. nov., isolated from human faeces”
    Int J Syst Evol Microbiol. 2015 Apr;65(Pt 4):1342-6
  9. Asama T., Kimura Y., Kono T., Fukushima S., Tatefuji T., and Benno Y.:
    “The effects of heat-killed Lactobacillus kunkeei YB38 on human intestinal environment and bowel movement: A pilot study..”
    Benef. Microbes, 7: 337-344 (2016)
  10. Odamaki T., Kato K, Sugahara H., Xiao J.-z, Abe F., and Benno Y.
    “Effect of probiotic yogurt on animal-based diet-induced disturbance in gut microbiota: an open, randomized, parallel-group study”
    Benef. Microbes. 7: 473-484 (2016)

Lab Members

Principal Investigator

Yoshimi Benno
Head of Benno Laboratory

Core Members

Taihei Banno
Technical Staff I
Yuko Shigeno
Technical Staff Ⅱ
Mutsumi Nakamura
Part-time Worker

Contact information

2-1 Hirosawa,
Wako, Saitama
351-0198, Japan
Tel: +81-(0)48-467-1949

Email: benno828 [at]