Centers & Labs

RIKEN Innovation Center

Four-Dimensional Multicellular Dynamics Laboratory

Team Leader: Toru Tanaka
Deputy Team Leader: Takashi Tsuji (Ph.D.)
Toru  Tanaka Takashi Tsuji

The Four-dimensional Multicellular Dynamics Laboratory (Team Leader: Toru Tanaka, Sub Leader: Takashi Tsuji) has established as a joint project between Andor Technology Ltd, Carl Zeiss Microscopy and RIKEN as part of the “Integrated Collaborative Research Program with Industry”. We aim to construct models and software for automated multicellular cell-tracking systems for the study of innovative four-dimensional multicellular dynamics through research into three-dimensional organ morphogenesis.

[Integrated Collaborative Research with Andor Technology Ltd. / Carl Zeiss Microscopy Co.,Ltd.]

Main Research Field

Biology

Related Research Fields

Mathematical and physical sciences

Keywords

  • Developmental Biology
  • morphology

Selected Publications

  1. Jun Ishikawa, Masamitsu Oshima, Fumitaka Iwasaki, Ryoji Suzuki, Joonhong Park, Kazuhisa Nakao, Yuki Matsuzawa-Adachi, Taro Mizutsuki, Ayaka Kobayashi, Yuta Abe, Eiji Kobayashi, Katsunari Tezuka and Takashi Tsuji.:
    "Hypothermic temperature effects on organ survival and restoration"
    Scientific Reports, in press, 2015.
  2. Masamitsu Oshima, Kaoru Inoue, Kei Nakajima, Tetsuhiko Tachikawa, Hiromichi Yamazaki,Tomohide Isobe, Ayaka Sugawara, Miho Ogawa, Chie Tanaka, Masahiro Saito, Shohei Kasugai,Teruko Takano-Yamamoto, Takashi Inoue, Katsunari Tezuka, Takuo Kuboki, Akira Yamaguchi and Takashi Tsuji.:
    "Functional tooth restoration by next-generation bio-hybrid implant as a bio-hybrid artificial organ replacement therapy."
    Scientific Reports 4:6044. DOI: 10.1038/srep06044, 2014
  3. Ogawa M, Oshima M, Imamura A, Sekine Y, Ishida K, Yamashita K, Nakajima K, Hirayama M, Tachikawa T, Tsuji T.:
    "Functional salivary gland regeneration by transplantation of a bioengineered organ germ."
    Nature Communications 4:2498. doi: 10.1038/ncomms3498, 2013.
  4. Hirayama M, Ogawa M, Oshima M, Sekine Y, Ishida K, Yamashita K, Ikeda K, Shimmura S, Kawakita T, Tsubota K, Tsuji T.
    "Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ."
    Nature Communications 4:2498. doi: 10.1038/ncomms3497, 2013.
  5. Kyosuke Asakawa, Koh-ei Toyoshima, Naoko Ishibashi, Hirofumi Tobe, Ayako Iwadate,Tatsuya Kanayama, Tomoko Hasegawa, Kazuhisa Nakao, Hiroshi Toki, Shotaro Noguchi,Miho Ogawa, Akio Sato, and Takashi Tsuji.:
    "Hair organ regeneration via the bioengineered hair follicular unit transplantation."
    Scientific Reports 2(424), DOI: 10.1038/srep00424, 2012.
  6. Koh-ei Toyoshima, Kyosuke Asakawa, Naoko Ishibashi, Hiroshi Toki, Miho Ogawa, Tomoko Hasegawa, Tarou Irié, Tetsuhiko Tachikawa, Akio Sato, Akira Takeda, and Takashi Tsuji.
    "Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches."
    Nature Communications 3(784), doi:10.1038/ncomms1784, 2012.
  7. Masamitsu Oshima, Mitsumasa Mizuno, Aya Imamura, Miho Ogawa, Masato Yasukawa, Hiromichi Yamazaki, Ritsuko Morita, Etsuko Ikeda, Kazuhisa Nakao, Teruko Takano-Yamamoto, Shohei Kasugai, Masahiro Saito and Takashi Tsuji.:
    Functional tooth regeneration using a bioengineered tooth unit as a mature organ replacement regenerative therapy.
    PLoS ONE 6(7):e21531, 2011.
  8. Etsuko Ikeda, Ritsuko Morita, Kazuhisa Nakao, Kentaro Ishida, Takashi Nakamura, Teruko Takano-Yamamoto, Miho Ogawa, Mitsumasa Mizuno, Shohei Kasugai and Takashi Tsuji.:
    Fully functional bioengineered tooth replacement as an organ replacement therapy.
    Proc. Natl. Acad. Sci. USA. 106(32), 13475-13480, 2009.
  9. Kazuhisa Nakao, Ritsuko Morita, Yasumitsu Saji, Kentaro Ishida, Yusuke Tomita, Miho Ogawa, Masahiro Saitoh, Yasuhiro Tomooka and Takashi Tsuji.
    The development of a bioengineered organ germ method.
    Nature Methods. 4, 227-230, 2007.

Lab Members

Principal Investigator

Toru Tanaka
Team Leader

Core Members

Takashi Tsuji
Deputy Team Leader
Mamoru Ishii
Research Scientist
Shigemitsu Koseki
Senior Visiting Scientist
Yasuhiko Sato
Visiting Scientist
Masako Yamaguchi
Visiting Scientist
Akira Sato
Visiting Scientist

Contact information

2-2-3 Minatojima-minamimachi,
Chuo-ku, Kobe, Hyogo
650-0047, Japan

Email: 4-d-multicellular-dynamics-lab [at] riken.jp

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