Centers & Labs

RIKEN Innovation Center

Organ Preservation and Resuscitation Laboratory

Team Leader: Syuhei Yoshimoto
Deputy Team Leader: Takashi Tsuji (Ph.D.)
Syuhei  Yoshimoto Takashi Tsuji

Organ transplant surgery has become the principle method to treat patients with dysfunctional organs. However, at present, the biggest hurdle to overcome is the severe shortage of available organs. To expand the supply of healthy donor organs, technological developments based on novel concepts are expected to improve organ preservation and resuscitation. In this project, we aim to develop a novel three-dimensional organ perfusion culture system that allows long-term preservation and resuscitation of severely ischemic organs in in vitro cultures. We hope to contribute to healthcare through the development of a novel technology to expand the supply of available organs.

[Integrated Collaborative Research with SCREEN Holdings Co.,Ltd.]

Main Research Field

Medicine, dentistry, and pharmacy

Related Research Fields

Engineering / Biology


  • Liver Transplantation
  • Machine perfusion
  • Organ Resuscitation
  • Marginal donor
  • Organ Preservation

Selected Publications

  1. Ishikawa J., Oshima M., Iwasaki F.:
    Suzuki R., Park J., Nakao K., Matsuzawa-Adachi Y., Mizutsuki T., Kobayashi A., Abe Y., Kobayashi E., Tezuka K. and Tsuji T.:
    “Hypothermic temperature effects on organ survival and restoration.”
    Sci. Rep. 5:9563. doi: 10.1038/srep09563 (2015).
  2. N Okada, K Mizuta and M Oshima.:
    N Yamada, Y Sanada, Y Ihara, T Urahashi, J Ishikawa,T Tsuji, S Hishikawa, T Teratani, and E Kobayashi.:
    “A Novel Split Liver Protocol Using the Subnormothermic Oxygenated Circuit System in a Porcine Model of a Marginal Donor Procedure.”
    Transplantation Proceedings, 47(2):419-426 (2015).

Lab Members

Principal Investigator

Syuhei Yoshimoto
Team Leader

Core Members

Takashi Tsuji
Deputy Team Leader
Shinji Torai
Visiting Scientist
Jun Ishikawa
Research Scientist

Contact information

Integrated Innovation Building,
6-7-1 Minatojima-minamimachi, Chuo-ku
Kobe, Hyogo
650-0047 Japan

Email: syuhei.yoshimoto [at]

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