Centers & Labs

RIKEN Innovation Center

RIKEN-HMC Clinical Omics Unit

Unit Leader: Yasuhiro Murakawa (M.D., Ph.D.)
Yasuhiro  Murakawa(M.D., Ph.D.)

Omics technologies allow for the detection of key drivers of diseases by systematic and high-throughput analyses of biological molecules. In particular, the advent of next-generation sequencing has revolutionized our understanding of human biology. In our research unit, we apply these omics technologies to rare or familial diseases. We aim to understand basic mechanisms of diseases and to develop innovative therapies and diagnostics.

[Collaborative Research with Hamad Medical Corporation]

Main Research Field

Medicine, dentistry, and pharmacy

Related Research Fields

Biology

Keywords

  • Omics Science
  • Rare Disease
  • Genetics
  • Next-generation sequencing
  • Biotechnology

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.
  1. Murakawa, Y.(#)(*), Yoshihara, M. (#), Kawaji H., Nishikawa M., Zayed H., Suzuki H., Fantom Consortium, Hayashizaki Y.: (* corresponding author ; # equally contributing first author)
    "Enhanced identification of transcriptinal enhancers provides mechanistic insights into diseases"
    Trends in Genetics 32, 76-88 (2016)
  2. *Hasler D., Lehmann G., Murakawa Y., Klironomos F., Jakob L., Grässer F., Rajewsky N., Landthaler M., Meister G.:
    "The Lupus autoantigen La prevents mis-channeling of tRNA fragments into the human microRNA pathway"
    Molecular Cell 63, 110-24 (2016)
  3. *Murakawa, Y., Hinz, M., Mothes, J., Schuetz, A., Yasuda, T., Mastrobuoni, G., Friedel, C.C., Dölken, L., Kempa, S., Schmidt-Supprian, M., Heinemann, U., Wolf, J, Scheidereit, C., Landthaler, M.:
    "RC3H1 represses the IKK/NF-κB negative feedback regulator A20 by binding to a 3’UTR composite structure-sequence element"
    Nature Communications 6, 7367 (2015)
  4. *Mino, T., Murakawa, Y., Fukao, A., Vandenbon, A., Wessels, H., Ori, D., Uehata, T., Tartey, S., Akira, S., Suzuki, Y., Vinueesa, GG., Ohler, U., Standley, DM., Landthaler, M., Fujiwara, T., Takeuchi, O.:
    "Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms"
    Cell 161, 1058-1073 (2015)
  5. *Rybak-Wolf, A. (#), Jens, M. (#), Murakawa, Y. (#), Herzog, M., Landthaler, M., Rajewsky, N.: (#equally contributing first author)
    "A variety of Dicer substrates in human and C.elegans"
    Cell 159, 1153-1167 (2014)
  6. *Schuetz, A., Murakawa, Y., Rosenbaum, E., Landthaler, M., Heinemann, U.:
    "Roquin binding to stem-loop mRNAs induces protein dimerization and involves a winged helix-turn-helix motif"
    Nature Communications 5, 5701 (2014)
  7. *Baltz, AG., Munschauer, M., Schwanhäusser, B., Vasile, A., Murakawa, Y., Schueler, M., Youngs, N., Penfold-Brown, D., Drew, K., Milek, M., Wyler, E., Bonneau, R., Selbach, M., Dieterich, C., Landthaler, M.:
    "The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts"
    Molecular Cell 46, 674-690 (2012)
  8. *Murakawa, Y., Miyagawa-Hayashino, A., Ogura, Y., Egawa, H., Okamoto, S., Soejima, Y., Kurosawa, M., Sumiyoshi, S., Uemoto, S., and Haga, H.:
    "Liver transplantation for severe hepatitis in patients with common variable immunodeficiency"
    Pediatric Transplantation 16, E210-216 (2012)
  9. *Murakawa, Y., Sonoda, E., Barber, L.J., Zeng, W., Yokomori, K., Kimura, H., Niimi, A., Lehmann, A., Zhao, G.Y., Hochegger, H., Boulton, SJ., Takeda, S.:
    "Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells"
    Cancer Research 67, 8536-8543 (2007)
  10. *Zhao, G.Y., Sonoda, E., Barber, L.J., Oka, H., Murakawa, Y., Yamada, K., Ikura, T., Wang, X., Kobayashi, M., Yamamoto, K., Boulton, S.J., Takeda, S.:
    "A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination"
    Molecular Cell 25, 663-675 (2007)

Contact information

W420,
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-9218
Fax: +81-(0)45-503-9219

Email: yasuhiro.murakawa [at] riken.jp