Centers & Labs

RIKEN Innovation Center

RIKEN-KFU Translational Genomics Unit

Unit Leader: Oleg Gusev (Ph.D.)
Oleg  Gusev(Ph.D.)

Modern technologies allow to combine data from thousands of sequenced genomes with sensitive methods of gene expression analysis to get new insights in mechanisms of gene regulation and to develop new diagnostic approaches for daily medical use. In our unit, we apply various methods of high-throughput RNA analysis and comparative genomics to reveal molecular background of diseases and aging-associated changes and to find new sensitive and universal molecular biomarkers for advanced diagnostics.

[Collaborative Research with Kazan Federal University, Russia]

Main Research Field

Biological Sciences

Related Research Fields

Medicine, dentistry, and pharmacy

Keywords

  • Genome science
  • RNA expression
  • Translational functional genomics
  • Biomimetics
  • Gene regulation of hypo metabolic processes and biomaterial preservation

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.
  1. Shagimardanova, E., Shigapova, L., Gusev, O., Nikitin, A., Druzhkov, M., Enikeev, R. and Gordiev, M.:
    "Germline BRCA screening in breast cancer patients in Tatar women populations"
    Annals of Oncology, 27, suppl 6 (2016).
  2. Kikuta, S., Watanabe, S. J., Sato, R., Gusev, O, Nesmelov, A., Sogame, Y., Cornette, R. and Kikawada, T.:
    "Towards water-free biobanks: long-term dry-preservation at room temperature of desiccation-densitive enzyme luciferase in air-dried insect cells."
    Scientific Reports (2017)(in press).
  3. Sogame, Y., Okada, J., Kikuta, S., Miyata, Y., Cornette, R., Gusev, O. and Kikawada, T.:
    "Establishment of gene transfer and gene silencing methods in a desiccation-tolerant cell line, Pv11"
    Extremophiles 21 (1), 65-72 (2017).
  4. *Islamov R., Gusev O., Tanabe A., Terada M., Tyapkina O., Petrov K., Rizvanov A., Kozlovskaya I., Nikolskiy E., Grigorjev A.:
    "Full-genome study of gene expression in lumbar spinal cord of mice after 30-day space flight on Bion-M1 biosatellite"
    Acta Astronautica. 122, 231-236 (2016).
  5. *Branco A., Pereira S., Gonzalez S., Gusev O., Rizvanov A., Oliveira P.:
    "Gene Expression Profiling of H9c2 Myoblast Differentiation towards a Cardiac-Like Phenotype"
    PLoS ONE. 29;10(6):e0129303 (2015).
  6. *Hatanaka R., Gusev O., Cornette R., Shimura S., Kikuta S., Okada J., Okuda T., Kikawada T.:
    "Genome-wide analysis of late embryonesis abundant (LEA) protein encoding genes in the anhydrobiotic midge Polypedilum vanderplanki"
    Planta 242 (2), 451-459 (2015).
  7. *Gusev O., Suetsugu Y., Cornette R.,Kawashima T., Logacheva M., Kondrashov A.,Penin A., Hatanaka R., Kikuta Sh., Shimura S., Katayose Y.,Matsumoto T., Shagimardanova E., Alexeev D.,Govorun V., Wisecaver J., Mikheyev A., Koyanagi R., Nishiyama T., Shigenobu Sh., Shibata T., Galygina V., Hasebe M., Okuda T., Satoh N. and Kikawada T.:
    "Comparative genome sequencing reveals genomic signature of extreme desiccation tolerance in the anhydrobiotic midge"
    Nature Communications. 5, 4784; doi:10.1038/ncomms 5784 (2014).
  8. *Gusev, O., Cornette, R., Kikawada T., and Okuda, T.:
    "Expression of heat shock proteins associated with anhydrobiosis in an African chironomid Polypedilum vanderplanki"
    Cell Stress & Chaperones. 16(1), 81-90 (2011).
  9. *Gusev, O., Nakahara Y., Vanayagina V., Malutina L., Cornette, R., Sakashita, T., Hamada N., Kobayashi, Y., Kikawada T., and Okuda, T.:
    "Nuclear DNA damage and reparation associated with anhydrobiosis in African chironomid and its impact to radioresistance"
    PloS ONE 5 (11), e14008 (2010).
  10. *Sugimoto M, Oono Y, Gusev O, Matsumoto T, Yazawa T, Levinskikh MA, Sychev VN, Bingham GE, Wheeler R, Hummerick M.:
    "Genome-wide expression analysis of reactive oxygen species gene network in Mizuna plants grown in long-term spaceflight"
    BMC Plant Biol.6;14(1):4 (2014).

Contact information

1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-9218

Email: oleg.gusev [at] riken.jp