A close relationship between T cells and phagocytes

A. Classic dichotomy model. Hematopoietic stem cells diverge into common myelo-erythroid progenitors and common lymphoid progenitors. The findings reported by I. Weissman's group that common lymphoid progenitors are present in adult BM has provided a support for this model.
B. Myeloid-based model. In this model, the first branch point generates common myelo-erythroid and common myelo-lymphoid progenitors, and the myeloid potential persists in the T and B cell branches even after these lineages have diverged. This model postulates that specification towards erythroid, T and B cell lineages proceeds on the basis of a prototypical myeloid program.

RIKEN Press Release A close relationship between T cells and phagocytes establishing a new paradigm in hematopoiesis

Figure 1. Models of lineage commitment during hematopoiesis A. Classic dichotomy model. Hematopoietic stem cells diverge into common myelo-erythroid progenitors and common lymphoid progenitors. The findings reported by I. Weissman's group that common lymphoid progenitors are present in adult BM has provided a support for this model. B. Myeloid-based model. In this model, the first branch point generates common myelo-erythroid and common myelo-lymphoid progenitors, and the myeloid potential persists in the T and B cell branches even after these lineages have diverged. This model postulates that specification towards erythroid, T and B cell lineages proceeds on the basis of a prototypical myeloid program.

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