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Experimental Animal Division
Atsushi YOSHIKI
Head of Experimental Animal Division
Atsushi YOSHIKI (Ph.D.)
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Research Areas

Mice have been the most useful animal models for humans and have contributed to life science research for gene function and the development of novel drugs and treatments for complex diseases. The primary mission of the Experimental Animal Division is to collect, preserve, conduct quality control, and distribute mouse models created in Japan. In addition, we develop novel mouse models that are necessary for emerging research needs and relevant technologies to achieve our primary mission: since FY2002, our division has been designated as the core facility for the mouse and the sub-facility for the rat in the National Bioresource Project (NBRP) of MEXT, Japan. We have thus contributed to the global promotion of life sciences by establishing high-quality mouse resources and backup storage of rat embryos and sperm.

Research Subject

  1. Collection, preservation, quality control and distribution of the mouse strains
  2. Collection and dissemination of mouse strain characteristics and relevant information
  3. Development of novel mouse resources and relevant technologies

Related links

  1. RIKEN BioResource Center Website_Laboratories PageNew Window
  2. Federation of International Mouse Resources PageNew Window

Press release

March 23,2010
Experimental mouse evolves in its feeding place and reaches maturity early without secreting melatonin

RIKEN RESEARCH

February 23, 2007
Mouse resource opens a new era of life science New Window

List of Selected Publications

  1. Yoshiki A.:
    "Dissemination of advanced mouse resources and technologies at RIKEN BioResource Center."
    Interdisciplinary Bio Central 2(15), Dec 24, 2010.
  2. Masuya H, Makita Y, Kobayashi N, Nishikata K, Yoshida Y, Mochizuki Y, Doi K, Takatsuki T, Waki K, Tanaka N, Ishii M, Matsushima A, Takahashi S, Hijikata A, Kozaki K, Furuichi T, Kawaji H, Wakana S, Nakamura Y, Yoshiki A, Murata T, Fukami-Kobayashi K, Mohan S, Ohara O, Hayashizaki Y, Mizoguchi R, Obata Y, Toyoda T.:
    "The RIKEN integrated database of mammals."
    Nucleic Acids Res 39 (database issue):D861-870. Epub 2010 Nov 13.
  3. Kasahara T, Abe K, Mekada K, Yoshiki A, Kato T.:
    "Genetic variation of melatonin productivity in laboratory mice under domestication."
    Proc Natl Acad Sci U S A 107: 6412-6417, 2010.
  4. Osipova DV, Kulikov AV, Mekada K, Yoshiki A, Moshkin MP, Kotenkova EV, Popova NK.:
    "Distribution of the C1473G polymorphism in tryptophan hydroxylase 2 gene in laboratory and wild mice"
    Genes Brain Behav 9(5):537-543, 2010.
  5. Pan J, Nakade K, Huang YC, Zhu ZW, Masuzaki S, Hasegawa H, Murata T, Yoshiki A, Yamaguchi N, Lee CH, Yang WC, Tsai EM, Obata Y, Yokoyama KK.:
    "Suppression of cell-cycle progression by Jun dimerization protein-2 (JDP2) involves downregulation of cyclin-A2."
    Oncogene 29: 6245-6256, 2010.
  6. Mekada, K., Abe, K., Murakami, A., Nakamura, S., Nakata, H., Moriwaki, K., Obata, Y., and Yoshiki, A.:
    "Genetic Differences among C57BL/6 Substrains."
    Exp Anim 58, 141-149, 2009.
  7. Oota S, Mekada K, Fujita Y, Humphries J, Fukami-Kobayashi K, Obata Y, Rowe T, Yoshiki A.:
    "Four-dimensional quantitative analysis of the gait of mutant mice using coarse-grained motion capture."
    Conf Proc IEEE Eng Med Biol Soc. 1:5227-5230, 2009.
  8. Nakata H, Hashimoto T, Seki Y, Mekada K, Obata Y, Yoshiki A.:
    "Simultaneous detection of multiple transgenes for genetically-modified mouse strains."
    Exp Anim. 58(4): 437-442, 2009.
  9. Yoshiki, A., Ike, F., Mekada, K., Kitaura, Y., Nakata, H., Hiraiwa, N., Mochida, K., Ijuin, M., Kadota, M., Murakami, A., Ogura, A., Abe, K., Moriwaki, K., and Obata, Y.:
    "The Mouse Resources at the RIKEN BioResource Center."
    Exp Anim 58, 85-96, 2009.
  10. Ogonuki, N., Inoue, K., Hirose, M., Miura, I., Mochida, K., Sato, T., Mise, N., Mekada, K., Yoshiki, A., Abe, K., Kurihara, H., Wakana, S., Ogura, A.:
    "A high-speed congenic strategy using first-wave male germ cells."
    PLoS ONE 4(3):e4943. Epub 2009 Mar 31.

Members

Principal Investigator

Atsushi YOSHIKI
Head

Staff Scientist

Kazuyuki MEKADA
Senior Research Scientist
Fumio IKE
Senior Research Scientist
Noriko HIRAIWA
Senior Technical Scientist
Hatsumi NAKATA
Senior Technical Scientist

Technical Assistant

Mizuho IWAMA
Technical Staff 2
Maiko IJUIN
Technical Staff 2
Reiko KAWAI
Technical Staff 2
Masashi YOKOTA
Technical Staff 2
Hiroyuki OKAMOTO
Technical Staff 2
Tomomi HASHIMOTO
Technical Staff 2
Kyuichi TAGUMA
Technical Staff 2
Hiroyasu HIRAKI
Technical Staff 2
Ayumi MURAKAMI
Technical Staff 2
Masayo KADOTA
Technical Staff 2
Megumi KOBAYASHI
Technical Staff 2