Experimental Animal Division
Mice have been the most useful animal models for humans and have contributed to life science research for gene function and the development of novel drugs and treatments for complex diseases. The primary mission of the Experimental Animal Division is to collect, preserve, conduct quality control, and distribute mouse models created in Japan. In addition, we develop novel mouse models that are necessary for emerging research needs and relevant technologies to achieve our primary mission: since FY2002, our division has been designated as the core facility for the mouse and the sub-facility for the rat in the National Bioresource Project (NBRP) of MEXT, Japan. We have thus contributed to the global promotion of life sciences by establishing high-quality mouse resources and backup storage of rat embryos and sperm.
- Collection, preservation, quality control and distribution of the mouse strains
- Collection and dissemination of mouse strain characteristics and relevant information
- Development of novel mouse resources and relevant technologies
- March 23,2010
- Experimental mouse evolves in its feeding place and reaches maturity early without secreting melatonin
- February 23, 2007
- Mouse resource opens a new era of life science
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- Yoshiki A.:
"Dissemination of advanced mouse resources and technologies at RIKEN BioResource Center."
Interdisciplinary Bio Central 2(15), Dec 24, 2010. - Masuya H, Makita Y, Kobayashi N, Nishikata K, Yoshida Y, Mochizuki Y, Doi K, Takatsuki T, Waki K, Tanaka N, Ishii M, Matsushima A, Takahashi S, Hijikata A, Kozaki K, Furuichi T, Kawaji H, Wakana S, Nakamura Y, Yoshiki A, Murata T, Fukami-Kobayashi K, Mohan S, Ohara O, Hayashizaki Y, Mizoguchi R, Obata Y, Toyoda T.:
"The RIKEN integrated database of mammals."
Nucleic Acids Res 39 (database issue):D861-870. Epub 2010 Nov 13. - Kasahara T, Abe K, Mekada K, Yoshiki A, Kato T.:
"Genetic variation of melatonin productivity in laboratory mice under domestication."
Proc Natl Acad Sci U S A 107: 6412-6417, 2010. - Osipova DV, Kulikov AV, Mekada K, Yoshiki A, Moshkin MP, Kotenkova EV, Popova NK.:
"Distribution of the C1473G polymorphism in tryptophan hydroxylase 2 gene in laboratory and wild mice"
Genes Brain Behav 9(5):537-543, 2010. - Pan J, Nakade K, Huang YC, Zhu ZW, Masuzaki S, Hasegawa H, Murata T, Yoshiki A, Yamaguchi N, Lee CH, Yang WC, Tsai EM, Obata Y, Yokoyama KK.:
"Suppression of cell-cycle progression by Jun dimerization protein-2 (JDP2) involves downregulation of cyclin-A2."
Oncogene 29: 6245-6256, 2010. - Mekada, K., Abe, K., Murakami, A., Nakamura, S., Nakata, H., Moriwaki, K., Obata, Y., and Yoshiki, A.:
"Genetic Differences among C57BL/6 Substrains."
Exp Anim 58, 141-149, 2009. - Oota S, Mekada K, Fujita Y, Humphries J, Fukami-Kobayashi K, Obata Y, Rowe T, Yoshiki A.:
"Four-dimensional quantitative analysis of the gait of mutant mice using coarse-grained motion capture."
Conf Proc IEEE Eng Med Biol Soc. 1:5227-5230, 2009. - Nakata H, Hashimoto T, Seki Y, Mekada K, Obata Y, Yoshiki A.:
"Simultaneous detection of multiple transgenes for genetically-modified mouse strains."
Exp Anim. 58(4): 437-442, 2009. - Yoshiki, A., Ike, F., Mekada, K., Kitaura, Y., Nakata, H., Hiraiwa, N., Mochida, K., Ijuin, M., Kadota, M., Murakami, A., Ogura, A., Abe, K., Moriwaki, K., and Obata, Y.:
"The Mouse Resources at the RIKEN BioResource Center."
Exp Anim 58, 85-96, 2009. - Ogonuki, N., Inoue, K., Hirose, M., Miura, I., Mochida, K., Sato, T., Mise, N., Mekada, K., Yoshiki, A., Abe, K., Kurihara, H., Wakana, S., Ogura, A.:
"A high-speed congenic strategy using first-wave male germ cells."
PLoS ONE 4(3):e4943. Epub 2009 Mar 31.
Principal Investigator
- Atsushi YOSHIKI
- Head
Staff Scientist
- Kazuyuki MEKADA
- Senior Research Scientist
- Fumio IKE
- Senior Research Scientist
- Noriko HIRAIWA
- Senior Technical Scientist
- Hatsumi NAKATA
- Senior Technical Scientist
Technical Assistant
- Mizuho IWAMA
- Technical Staff 2
- Maiko IJUIN
- Technical Staff 2
- Reiko KAWAI
- Technical Staff 2
- Masashi YOKOTA
- Technical Staff 2
- Hiroyuki OKAMOTO
- Technical Staff 2
- Tomomi HASHIMOTO
- Technical Staff 2
- Kyuichi TAGUMA
- Technical Staff 2
- Hiroyasu HIRAKI
- Technical Staff 2
- Ayumi MURAKAMI
- Technical Staff 2
- Masayo KADOTA
- Technical Staff 2
- Megumi KOBAYASHI
- Technical Staff 2

