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Laboratory for Systems Biology
Hiroki R. UEDA
Project Leader
Hiroki R. UEDA (M.D.,Ph.D.)
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Research Areas

One of the major challenges in current biology is system-level understanding of dynamic and complex biological phenomena. The laboratory for systems biology has specific aims at development of the systems-biological technologies to dissect dynamic and complex biological systems, that covering atomic-level to molecular-level, cellular/tissue-level and organism-level, and their application for system-level understanding of the dynamic and complex organism-level biological processes such as mammalian circadian rhythm and early embryogenesis.

Research Subject

  1. Robustness of biological clock from the atomic level
  2. The season-detection mechanism of biological calendar from the molecular level.
  3. The hourglass mechanism of sleep from the cellular level
  4. Development of the systems-biological technologies to dissect dynamic and complex organism-level biological systems

Related links

  1. RIKEN Center for Developmental Biology Website_Laboratories PageNew Window
  2. Individual Website Laboratory PageNew Window

RIKEN RESEARCH

January 28,2011
Gearing-up for spring
Rapid activation of specific genes readies the mammalian body for seasonal change New Window
July 24,2009
Day in and day out
Fluctuations in the levels of various molecules in the blood provide a reliable indicator of the body's internal cloNew Window
March 05,2009
Decoding the rhythm of life
Genomic studies have now provided enough understanding to design clock genes New Window
January 16,2009
Setting the cellular clock
Synthetic genetic circuits enable researchers to uncover the mechanisms by which cells set their internal clocks New Window
February 01,2008
How light can scramble time
Researchers solve the mystery of how biological clocks are disrupted New Window

List of Selected Publications

  1. Ukai H, and Ueda HR.:
    "Systems Biology of Mammalian Circadian Clocks"
    Annual Review of Physiology 72: 579-603 (2010)
  2. Masumoto KH, Ukai-Tadenuma M, Kasukawa T, Nagano M, Uno KD, Tsujino K, Horikawa K, Shigeyoshi Y, Ueda HR.:
    "Acute induction of Eya3 by late-night light stimulation triggers TSHβ expression in photoperiodism."
    Current Biology. Jan 11;21(1):R22-5 (2011)
  3. Ukai-Tadenuma M, Yamada RG, Xu H, Ripperger JA, Liu AC, Ueda HR.:
    "Delay in feedback repression by cryptochrome 1 is required for circadian clock function."
    Cell. Jan 21;144(2):268-81(2011)
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