List of Selected Publications

1. Sugimoto, H., Oda, S., Otsuki, T., Hino, T., Yoshida, T., and Shiro, Y.:
   "Crystal Structure of Human Indoleamine 2,3-dioxygenase: Insighhts into the Catalytic Mechanism of O2 Incorporation by a Heme-containing Dioxygenase."
   Proc. Natl. Acad. Sci. USA, 103, 2611-2616 (2006)
2. Kumita, H., Matsuura, K., Hino, S., Hori, H., Fukumori, Y., Morishima, I., and Shiro, Y.:
   "NO Reduction by Nitric Oxide Reductase from Denitrifying Bacterium Pseudomonas aeruginosa: Characterization of Reaction Intermediates That Appear in the Single-Turnover Cycle."
   J. Biol. Chem., 279, 55247-55254 (2004).
3. Nakamura, H., Kumita, H., Imai, K., Iizuka, T., and Shiro, Y.:
   "ADP Reduces the Oxygen Affinity of a Semsory Histidine Kinase FixL: The Possibility of an Enhanced Reciprocating Kinase Reaction."
   Proc. Natl. Acad. Sci. USA, 101, 2742-2746 (2004).
4. Hayashi, K., Sugimoto, H., Shinkyo, R., Yamada, M., Ikeda, S., Ikushiro, S., Kamakura, M., Shiro, Y., Sakaki ,T.:
   "Structure-based Design of a Highly Active Vitamin D Hydroxylase from Streptomyces griseolus CYP105A1."
   Biochemistry 47, 11964-11972 (2008)
5. Yamada, S., Sugimoto, H., Kobayashi, M., Ohno, A., Nakamura, H., Shiro, Y.:
   "Structure of PAS-linked Histidine Kinase and the Response Regulator Complex."
   Structure 17, 1333-1344 (2009)
6. Wang, Y., Chen, H., Makino, M., Shiro, Y., Nagano, S., Asamizu, S., Onaka, H., Sason, S.:
   "Theoretical and Experimental Studies of the Conversion of Chromopyrrolic Acid to an Antitumor Derivative by Cytochrome P450 StaP: The Biological Role of Water Molecules.
   J. Am. Chem. Soc. 131, 6748-6762 (2009)
7. Shoji, O., Fujishiro, T., Nakajima, T., Kim, M., Nagano, S., Shiro, Y., Watanabe, Y.:
   "Hydrogen Peroxide Dependent Monooxygenations by Tricking the Substrate Recognition of Cytochrome P450BSβ.
   Angw. Chem. Int. Ed. 46, 3656-3659 (2007)
8. Makino, M., Sugimoto, H., Shiro, Y., Asamizu, S., Onaka, H., Nagano, S.:
   "Crystal Structures and Catalytic Mechanism of Cytochrome P450 StaP That Produces The Indolocarbazole Skeleton.
   Proc. Natl. Acad. Sci. USA 104, 11591-11596 (2007)
9. Mizuno, H., Mal T. K., Welchli M., Kikuchi, A., Fukano, T., Ando, R., Jeyakanthan, J., Taka, J. Shiro, Y., Ikura, M., Miyawaki, A.:
   "Light-dependent Regulation of Structural Flexibility in a Photochromic Fluorescent Protein.
   Proc. Natl. Acad. Sci. USA 105, 9927-9932 (2008)
10. Sawai, H., Sugimoto, H., Kato, Y., Asano, Y., Shiro, Y., Aono, S.:
    "X-ray Crystal Structure of the Michaelis Complex of Aldoxime Dehydratase.
    J. Biol. Chem. 284, 32089-32096 (2009)

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