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Semyanov Research Unit
Alexey SEMYANOV
Unit Leader
Alexey SEMYANOV (Ph.D.)
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Research Areas

We use electrophysiological and imaging techniques to reveal the functions of extrasynaptic interactions in the brain. This involves studying release and uptake of extrasynaptic signalling molecules, their diffusion in the extracellular space, and localisation and properties of their receptors.

Research Subject

  1. Role of astrocytes in synaptic transmission and extrasynaptic signaling (Tang, X)
  2. Tonic activation of extrasynaptic GABA receptors in neurons of GAD65 knockout animals (Song, I)
  3. Functional role of cell compartment specific activation of extrasynaptic NMDA receptors (Wu, Y-W)
  4. Regulation of glutamate transporter function in astrocytes (Shih, P-Y)

Related links

  1. RIKEN Brain Science Institute Website_Laboratories PageNew Window
  2. Individual Website Laboratory PageNew Window

List of Selected Publications

  1. Scimemi, A., Semyanov, A., Sperk, G., Kullmann, DM., and Walker, MC.:
    "Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus."
    J.Neurosci., 25(44) (2005).
  2. Semyanov, A., Walker, M.C., Kullmann, D.M., and Silver, R.A.:
    "Tonically active GABAA receptors: modulating gain and maintaining the tone."
    Trends in Neurosciences, 27 262-269 (2004).
  3. Semyanov, A., Walker, M.C., and Kullmann, D.M.:
    "GABA uptake regulates cortical excitability via cell type-specific tonic inhibition."
    Nature Neurosci., 6 484-490 (2003).
  4. Semyanov, A., and Kullmann, D.M.:
    "Kainate receptor-dependent axonal depolarization and action potential initiation in interneurons."
    Nature Neurosci., 4, 718-723 (2001).
  5. Semyanov, A., and Kullmann, D.M.:
    "Modulation of GABAergic signaling among interneurons by metabotropic glutamate receptors."
    Neuron, 25, 663-672 (2000).
  6. Semyanov, A.:
    "Can diffuse extrasynaptic signaling form a guiding template."
    Neurochem Int. Jan;52(1-2):31-3(2008).
  7. Walker, MC., and Semyanov, A:
    "Regulation of Excitability by Extrasynaptic GABA(A) Receptors."
    Inhibitory Regulation of Excitatory Neurotransmission Series: Results and Problems in Cell Differentiation, Darlison, Mark G. (Ed.)2007, Approx. 220 p., 24 illus., Hardcover ISBN: 978-3-540-72601-2 (chapter) Results Probl Cell Differ.;44:29-48 (2008).
  8. Wanaverbecq ,N., Semyanov, A., Pavlov, I., Walker, MC., and Kullmann, DM.:
    "Cholinergic Axons Modulate GABAergic Signaling among Hippocampal Interneurons via Postsynaptic 7 Nicotinic Receptors."
    J.Neurosci. V.27(21):5683-5693(2007).
  9. Pavlov, I., Savtchenko, L., Kullmann, DK., Semyanov, A.,and Walker, MC.:
    "Outwardly rectifying tonically active GABAA receptors in pyramidal cells modulate neuronal offset, not gain."
    J.Neurosci. 29(48):15341-15350(2009).
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