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Laboratory for Cognitive Brain Mapping
Keiji TANAKA
Laboratory Head
Keiji TANAKA (Ph.D.)
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Research Areas

To reveal mechanisms of higher brain functions such as recognition and decision making, we are conducting experiments with non-human primates and functional MRI with a 4T system on normal human subjects. In the research with non-human primates, the animals are trained with various behavioral paradigms, and effects of functional blocage of particular brain sites or connections are examined and single-cell recordings are conducted during the task performance. We are focusing on the mechanisms of visual object recognition in the inferotemporal cortex and those of goal-directed behavior in the prefrontal cortex. To relate research results in human subjects with those in experimental animals, we are also making efforts to increase the spatial resolution of fMRI with human subjects.

Research Subject

  1. From the visual object recognition to semantic memory
  2. Functional differentiation among the prefrontal regions
  3. Projection-specific functional blockage in macaque monkeys
  4. fMRI of human cortical functions with columnar spatial resolution

Related links

  1. RIKEN Brain Science Institute Website_Laboratories PageNew Window
  2. Individual Website Laboratory PageNew Window

Press release

January 21, 2011
Researchers uncover neural origins of expert intuition
July 3, 2009
Mapping the prefrontal cortex
October 26, 2007
Damage to a specific brain area impairs the decision processNew Window
October 15, 2007
High-resolution brain mapping taken to next levelNew Window
April 23, 2007
Laboratory for Cognitive Brain Mapping of BSI elucidated a neuronal mechanism by which the brain learns correctness/incorrectness.

RIKEN RESEARCH

September 18, 2009
The brains behind rule-guided behaviorNew Window
February 21, 2008
Neural architectureNew Window

List of Selected Publications

  1. Cheng, K., Waggoner, R. A., Tanaka, K.
    "Human ocular dominance columns as revealed by high-field functional magnetic resonance imaging."
    Neuron, 32, 359-374 (2001).
  2. Matsumoto, K., Suzuki, W., Tanaka, K.
    "Neuronal correlates of goal-based motor selection in the prefrontal cortex."
    Science, 301, 229-232 (2003).
  3. Gardner, J.L., Sun, P., Waggoner, R.A., Ueno, K., Tanaka, K., Cheng, K.
    "Contrast adaptation and representation in human early visual cortex."
    Neuron, 47, 1-14 (2005).
  4. Wang, G., Obama, S., Yamashita, W., Sugihara, T., Tanaka, K.
    "View-invariant object recognition without experience of object rotations."
    Nature Neuroscience, 8, 1568-1575 (2005).
  5. Mansouri, F., Matsumoto, K., Tanaka, K.
    "Prefrontal cell activities related to monkeys' success and failure in adapting to rule changes in a Wisconsin Card Sorting Test (WCST) analog."
    J. Neuroscience, 26, 2745-2756 (2006).
  6. Matsumoto, M. Matsumoto, K, Abe, H., Tanaka, K.
    "Medial Prefrontal Cell Activity Signaling Prediction Errors of Action Values."
    Nature Neuroscience, 10, 647-656 (2007)
  7. Matsumoto, M. Matsumoto, K, Abe, H., Tanaka, K.
    "Medial Prefrontal Cell Activity Signaling Prediction Errors of Action Values."
    Nature Neuroscience, 10, 647-656 (2007)
  8. Mansouri, F.A., Buckley, M.J., Tanaka, K.
    "Mnemonic function of lateral prefrontal cortex in conflict-induced behavioral adjustment."
    Science 318: 987-990 (2007)
  9. Buckley, M.J., Mansouri, F.A., Hoda, H., Mahboubi, M., Browning, P.G.F., Kwok, S.C., Phillips, A., Tanaka, K.
    "Dissociable Components of Rule-Guided Behavior Depend on Distinct Medial and Prefrontal Regions."
    Science 325: 52-58 (2009)
  10. Wan, X., Nakatani, H., Ueno, K., Asamizuya, T., Cheng, K., Tanaka, K.
    "The neural basis of intuitive best next-move generation in board game experts."
    Science 331: 341-346 (2011)
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