Kondo Research Unit
Unit Leader
Takashi KONDO (Ph.D.)
Architecture of multi-cellular organisms are closely linked with their functions.During embryogenesis, transcriptions of genes are regulated temporally and spatially restricted manner to construct proper body structures. Within a brain, complex patterning is also required to achieve correct construction of functional architecture.Whereas many lines of results are accumulated for enhancer and promoter activities, it is not sufficient to explain how correct expressions of multiple genes within a genome can be accomplished. Although it is recognized that interaction of these elements has to be organized, it remains unclear the way these cis-regulatory elements co-operate and interact within a genome.Our primary aim is to investigate the influences from chromosomal environment and nuclear structure on transcription.
- Analysis of higher order regulatory mechnism of Evx and Hox locus.
- Visualization of chromosomal loci and analysis of their dynamics.
- Development of taste recognition system in mammalian
- January 24, 2007
- Researchers at the Kondo Research Unit of BSI have revealed that a certain DNA sequence called "boundary" controls other gene expressions on the same chromosome.
- April 03, 2009
- Identifying transcription modulators for the appearance of taste receptor cells through computer analysis, revealing that the selected Hes1 gene suppresses the differentiation of stem cells into taste receptor cells
- Ota, M.S., Kaneko, Y. Kondo, K., Ogishima, S., Tanaka, H., Eto, K., and Kondo, T.
"Combined in silico and in vivo analyses reveal role of Hes1 in taste cell differentiation"
PLoS Genetics 5, e1000443 (2009). - Yamagishi, T., Hirose, S., and Kondo, T.:
"Secondary DNA structure formation of Hoxb8 promoter and identification of its binding protein."
Nucleic Acids Research 36, 1965-1975 (2008). - Misra, R.K., Yamagishi, T., Vasanthi, D., Ohtsuka, C., and Kondo, T.:
"Involvement of Polycomb-group genes in establishing HoxD temporal colinearity."
Genesis 45, 570-576 (2007). - Yamagishi, T., Ozawa, M., Ohtsuka, C., Ohyama-Goto, R., and Kondo, T.:
"Evx2-Hoxd13 intergenic region restricts enhancer association to Hoxd13 promoter."
PLoS ONE 2, e175-1-e175-8 (2007). - Yamada, M., Tanemura, K., Okada, S., Iwanami, A., Nakamura, M., Mizuno, H., Ozawa, M., Ohyama-Goto, R., Kitamura, N., Kawano, M., Tan-Takeuchi K., Ohtsuka, C., Miyawaki, A., Takashima, A., Ogawa, M., Toyama Y., Okano, H., and Kondo, T.:
"Electrical stimulation modulates fate determination of differentiating embryonic stem cells."
Stem Cells 25, 562-570 (2007). - Matsugami, T.R., Tanemura, K., Mieda, M., Nakatomi, R., Yamada, K., Kondo, T., Ogawa, M., Obata, K., Watanabe, M., Hashikawa, T., and Tanaka, K.:
"Indispensability of the glutamate transporters GLAST and GLT1 to brain development."
Proc. Natl. Acad. Sci. USA 103, 12161-12166 (2006). - Tanemura, K., Ogura, A., Cheong, C., Goto, H., Matsumoto, K., Sato, E., Hayashi, Y., Lee, H.-A., and Kondo, T.:
"Dynamic rearrangement of telomeres during spermatogenesis in mice."
Dev. Biol. 281, 196-207 (2005). - Kmita, M., Kondo, T., and Duboule, D.:
"Targeted inversion of a polar silencer within the HoxD complex re-allocates domains of enhancer sharing."
Nature Genetics 26, 451-454 (2000). - Kondo, T., and Duboule, D.:
"Breaking colinearity in the mouse HoxD complex."
Cell 97, 407-417 (1999). - Kondo, T., Zakany, J., and Duboule, D.:
"Control of colinearity in the AbdB genes of the mouse HoxD complex."
Mol. Cell 1, 289-300 (1998).