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Support Unit for Neuromorphological Analysis
Tsutomu HASHIKAWA
Laboratory Head
Tsutomu HASHIKAWA (Ph.D.)
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Research Areas

Support Unit for Neuromorphological Analysis in the BSI Research Resource Center is devoted to offer of qualified surroundings for the morphological analysis of neural tissues, involving maintenance of the facilities such as electron microscope, laser scanning confocal microscope etc., and technical assistance in tissue preparation, microscope operation and data analysis. Construction of neuromorphological data bases (e.g. brain atlases) will also be another aspect of our activities.

Research Subject

  1. This unit provides highly skilled technical support in microscopic neural tissue analysis being performed in the Brain Science Institute laboratories.

Related links

  1. RIKEN Brain Science Institute Website_Laboratories PageNew Window

Press release

August 16 ,2010
Formation of nuclear membrane cavity complex directed by cell cycle engine

List of Selected Publications

  1. Maeshma K, Iino H, Hihara S, Funakoshi T, Watanabe A, Nishimura M, Nakatomi R, Yahata K, Imamoto F,Hashikawa T, Yokota H, Imamoto N;
    "Nuclear pore formation but not nuclear growth is governed by cyclin-dependent kinases (Cdks) during interphase."
    Nat. Struct. Mol. Biol., 17. 1065-1071 (2010)
  2. Li Y-C, Bai W-Z, Zhou L, Sun L-K, Hashikawa T;
    "Nonhomogeneous distribution of filamentous actin in the presynaptic terminals on the spinal motoneurons."
    J. Comp. Neurol., 518. 3183-3192 (2010)
  3. Naritsuka H, Sakai S, Hashikawa T, Mori K, Yamaguchi M;
    "Perisomatic-targetting granule cells in the mouse olfactory bulb."
    J. Comp. Neurol., 515. 409-426 (2009).
  4. Takaji M, Komatsu Y, Watakabe A, Hashikawa T, Yamamori T;
    "Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in the association areas in a primate specific manner."
    Cereb. Cortex, 19. 2865-2879 (2009).
  5. Li Y-C, Bai W-Z, Sakai K, Hashikawa T;
    "Fluorescence and electron microscopic localization of F-actin in the ependymocytes."
    J. Histochem. Cytochem., 57. 741-751 (2009)
  6. Sakurai T, Kaneko K, Okuno M, Wada K, Kashiyama T, Shimizu H, Akagi T, Hashikawa T, Nukina N;
    "Membrane microdomain switching a regulatory mechanism of amyloid precursor protein processing."
    J. Cell Biol., 183. 339-352 (2008)
  7. Li Y-C, W.-Z. Bai W-Z, Hashikawa T;
    "Postnatal reorganization of F-actin in the central canal of the spinal cord in the rat."
    Brain Res., 1239. 100-106 (2008).
  8. Yamazaki Y, Horibata Y, Nagatsuka Y, Hirabayashi Y, Hashikawa T;
    "Fucoganglioside a-fucosyl (a-galactosyl)-GM1: a novel member of lipid membrane microdomain components involved in PC12 cell neuritogenesis."
    Biochem. J., 407. 31-40 (2007).
  9. Saleem K., Price J., and Hashikawa T.:
    "Cytoarchitectonic and chemoarchitectonic subdivisions of the perirhinal and parahippocampal cortices in macaque monkeys."
    J. Com. Neurol., 500, 973-1006 (2007).
  10. Matsugami T., Tanemura K., Mieda M., Nakatomi R., Yamada K., Kondo T., Ogawa M., Obata K., Watanabe M., Hashikawa T., and Tanaka K.:
    "Indispensability of the glutamate transporters GLAST and GLT1 to brain development."
    Proc. Natl. Acad. Sci. USA 103, 12161-12166 (2006).