Plant Immunity Research Group
Group Director
Ken SHIRASU (Ph.D.)
Our ultimate goal is to fully describe functions of genes, proteins and small molecular compounds that are essential for immunity in plants. As the first step, we focus on regulatory mechanism of immunity by studying dynamics of resistance signaling complexes and protein modifications that control defense responses. In addition, we plan to identify novel genes involved in plant immunity by isolating defense mutants in model plants. We also collaborate with the Metabolomics Research Group to isolate small molecule compounds involved in disease resistance.
- Characterization of plant immunity signaling complexes
- Characterization of ubiquitin ligases involved in plant immunity
- Isolation and characterization of novel genes in plant immunity by chemical genetics
- Plant pathogen genomics
- Molecular analysis of parasitic plant Striga
- May 28, 2010
- Parasite plants rob genes from their hosts
- November 27,2009
- Putting the brakes on cell death
Internal degradation within plant cells and their response to aging and disease are linked
- Yoshida S., Maruyama S., Nozaki H., Shirasu K.
"Horizontal Gene Transfer by the Parasitic Plant Striga hermonthica."
Science 328:1128 (2010) - Zhang M., Kadota Y., Prodromou C., Shirasu K., Pearl L. H.
"Structural Basis for Assembly of Hsp90-Sgt1-CHORD Protein Complexes: Implications for Chaperoning of NLR Innate Immunity Receptors."
Molecular Cell 39:269-281. (2010) - Trujillo, M., Ichimura, K., Casais, C. and Shirasu, K.
"Negative regulation of PAMP-triggered immunity by E3 ubiquitin ligase triplet in Arabidopsis."
Current Biology 18:1396-1401. (2008) - Umehara, M., Hanada, A., Yoshida, S., Akiyama, K., Arite, T., Takeda-Kamiya, N., Magome, H., Kamiya, Y., Shirasu, K., Yoneyama, K., Kyozuka, J. and Yamaguchi, S.
"Inhibition of shoot branching by new terpenoid plant hormones."
Nature 455: 195-200. (2008) - Yoshimoto K., Jikumaru Y., Kamiya Y., Kusano M., Consonni C., Panstruga R., Ohsumi Y. and Shirasu K.
"Autophagy Negatively Regulates Cell Death by Controlling NPR1-Dependent Salicylic Acid Signaling during Senescence and the Innate Immune Response in Arabidopsis. "
Plant Cell 21:2914-2927 (2009) - Sugiyama, N., Nakagami, H., Mochida, K., Daudi, A., Tomita, M., Shirasu, K. and Ishihama, Y.
"Large-scale phosphorylation mapping reveales the extent of tyrosine phosphorylation in Arabidopsis."
Molecular Systems Biology 4:193 (2008) - Maor, R., Jones, A., Nuhse, T.S., Studholme, D.J., Peck, S.C. and Shirasu, K.
"MudPIT analysis of ubiquitinated proteins in plants."
Molecular & Cellular Proteomics 6: 601-610. (2007) - Azevedo, C., Betsuyaku, S., Peart, J., Takahashi, A., Noel, L., Sadanandom, A., Casais, C., Parker, J. and Shirasu, K.
"Role of SGT1 in resistance protein accumulation in plant immunity."
EMBO J. 25: 2007-2016. (2006) - Takahashi, A., Casais, C., Ichimura, K. and Shirasu, K.
"HSP90 interacts with RAR1 and SGT1, and is essential for RPS2-mediated disease resistance in Arabidopsis."
Proc. Acad. Natl. Sci. U.S.A.100: 11777-11782. (2003) - Azevedo, C., Sadanandom, A., Kitagawa, K., Freialdenhoven, A., Shirasu, K. and Schulze-Lefert, P.
"The RAR1 interactor SGT1, an essential component of R-gene triggered disease resistance."
Science 295: 2073-2076.(2002)
Principal Investigator
- Ken SHIRASU
- Group Director
Members
- Satoko YOSHIDA
- Senior Research Scientist
- Takashi YAENO
- Research Scientist
- Yasuhiro KADOTA
- Special Postdoctoral Researcher
- Rebecca Louise LYONS
- Foreign Postdoctoral Researcher
- Pamela Hui Peng GAN
- Postdoctoral Researcher
- Yuko SEKIMOTO
- Visiting Researcher
- Kaori TAKIZAWA
- Technical Staff