Laboratory for Developmental Genetics

Group Director
Haruhiko KOSEKI (M.D., Ph.D.)
Our efforts are mainly focused to understand correlation between structures and functions of the chromatin during mouse embryogenesis. In particular, we are analyzing functions of a class of chromatin modifiers, Polycomb group, in transcriptional regulation of Hox cluster and Ink4a loci. Up to now, we have systematically addressed functions of individual components of Polycomb group complexes by using mouse mutants and started the investigations how the functions of these proteins were mutually regulated. We are also involved in administration of animal facility of RCAI and provide services for generation and storage of genetic resources.
- Genetic and biochemical dissection of functions of mammalian Polycomb-group protein complexes
- Generation and preservation of genetic resources
- February 16, 2009
- Identifying a new regulation mechanism for joint formation by FGF9, a factor involved in cartilage or bone formation through its dimerization and controlled localization.
- February 17, 2009
- Development of a nano-scale manufacturing technology with photons, which can regulate metalic ion recrystallization and enable flexible three-dimensional manufacturing of nano-sized metals.
- July 18, 2008
- How do cells read genetic information?
- Hirabayashi, Y., Suzki, N., Tsuboi, M., Endo, T.A., Toyoda, T., Shinga, J., Koseki, H., Vidal, M.,and Gotoh, Y.:
"Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition."
Neuron. 63(5):600-13 (2009) - Schwermann, J., Rathinam, C., Schubert, M., Schumacher, S., Noyan, F., Koseki, H., Kotlyarov, A., Klein, C.,and Gaestel, M.:
"MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells."
EMBO J. 28(10):1392-406, (2009) - Harada, M., Murakami, H., Okawa, A., Okimoto, N., Hiraoka, S., Nakahara, T., Akasaka, R., Shiraishi, YI., Futatsugi,N, Mizutani-Koseki, Y, Kuroiwa, A, Shirouzu, M, Yokoyama, S, Taiji, M, Iseki, S, Ornitz, DM.,and Koseki, H.:
"FGF9 monomer-dimer equilibrium regulates extracellular matrix affinity and tissue diffusion."
Nat Genet. 41: 289-98, (2009) - Puschendorf, M., Terranova, R., Boutsma, E., Mao, X., Isono, K., Brykczynska, U., Kolb, C., Otte, A.P., Koseki, H., Orkin, S.H., van Lohuizen, M.,and Peters, A.H.:
"PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos."
Nat Genet. 40:411-20, (2008) - Endoh, M., Endo, TA., Endoh, T., Fujimura, Y., Ohara, O., Toyada, T., Otte, A.P., Okano, M., Brockdorff, N., Vidal, M.,and Koseki, H.:
"Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity."
Development 135:1513-24, (2008) - Calés, C., Román-Trufero, M., Pavón, L., Serrano, I., Melgar, T., Endoh, M., Pérez, C., Koseki, H.,and Vidal, M.:
"Inactivation of the polycomb group protein Ring1B unveils an antiproliferative role in hematopoietic cell expansion and cooperation with tumorigenesis associated with Ink4a deletion."
Mol Cell Biol. 28:1018-28, (2008) - Sharif, J., Muto M., Takebayashi, S., Suetake, I., Iwamatsu, A., Endo, T.A., Shinga, J., Mizutani-Koseki, Y., Toyoda, T., Okamura, K., Tajima, S., Mitsuya, K., Okano, M.,and Koseki, H.:
"The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA."
Nature 450: 908-912, (2007) - Hiraoka, S., Furuichi, T., Nishimura, G., Shibata, S., Yanagishita, M., Rimoin, D.L., Superti-Furga, A., Nikkels, P.G., Ogawa, M., Katsuyama, K., Isono, K., Toyoda, H., Kinoshita-Toyoda, A., Ishida, N., Sanai, Y., Cohn, D.H,, Koseki, H., Ikegawa, S.:
"Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human."
Nat Med. 13: 1363-1367, (2007) - Elderkin, S., Maertens, G.N., Endoh, M., Mallery, D., Morrice, N., Koseki, H., Peters, G., Brockdorff, N., Hiom, K.:
"A phosphorylated form of Mel-18 targets the Ring1B histone H2A ubiquitin ligase to chromatin."
Mol. Cell 28: 107-120, (2007) - Takada Y, Isono K, Shinga J, Turner JMA, Kitamura H, Ohara O, Watanabe G, Singh PB, Kamijo T, Jenuwein T, Burgoyne PS, Koseki H
"Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes"
Development 134: 579-590, (2007)
Principal Investigator
- Haruhiko KOSEKI
- Group Director
Members
- Koji HASE
- Kyoichi ISONO
- Takanori HASEGAWA
- Takashi KONDO
- Mitsuhiro ENDOH
- Yu-ichi FUJIMURA
- Yixin DONG
- Daisuke YAMADA
- Osamu MASUI
- Shinobu MOCHIZUKI
- Yuki HORISAWA
- Nayuta YAKUSHIJI
- Shinsuke ITO
- Jafar SHARIF
- Kit Wan MA
- Yukihiro FURUSAWA
- Tamie MORISAWA
- Tomoyuki ISHIKURA
- Chieko TEZUKA
- Momoko OKOSHI
- Genta KITAHARA
- Naoko ONAGA
- Kayoko KATSUYAMA
- Rie SUZUKI
- Yoko KOSEKI
- Fuyuko SHIOTANI
- Raul Eduardo VIZCARDO SAKODA
- Yusuke IIZUKA
- Hiromi TATSUMI
- Yurie KAWAMOTO
- Masako FUJITA
- Chie YOSHIDA
- Mami KUMON
- Masayo HARADA
- Visiting Scientist
- Masahiro MUTO
- Visiting Scientist
- Kaori KONDO
- Keiko TAKAHASHI
- Masashi MATSUDA