Laboratory for Transcriptional Regulation
Research Areas
| Transcriptional regulation by transcription factors network plays central roles in regulating development of multicellular organisms. The aim of our research team is to understand transcriptional regulation that governs genetic programming of lymphocyte development. In particular, we will focus on functions of Runx transcription factor family and mechanisms of silencer-mediated gene regulation. Finally, we wish to apply our findings to develop new technology that will be applied to control human diseases. |  Team Leader Ichiro TANIUCHI (M.D., Ph.D.)  |
Research Subjects
| (1) | Roles of Runx family during immune cell development |
| (2) | Mechanism of silencer-mediated gene regulation |
List of Selected Publications
| (1) | Collins, A., Littman, D.R., and Taniuchi, I.: "RUNX proteins in transcription factor networks that regulate T-cell lineage choice." Nat. Rev. Immunol. 9:106-15 (2009) |
| (2) | Muroi, S., Naoe, Y., Miyamoto, C., Akiyama, K., Ikawa, T., Masuda, K., Kawamoto, H., and Taniuchi, I.: "Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate." Nat. Immunol. 9:1113-21 (2008) |
| (3) | Setoguchi, R., Tachibana, M., Naoe, Y., Muroi, S., Akiyama, K., Tezuka, C., Okuda, T., and Taniuchi I.: "Repression of the Transcription Factor Th-POK by Runx Complexes in Cytotoxic T Cell Development." Science, 319, 816-819 (2008). |
| (4) | Naoe, Y., Setoguchi, R., Akiyama, K., Muroi, S., Kuroda, M., Hatam, F., Littman, D.R., and Taniuchi, I.: "Repression of interleukin-4 in T helper type 1 cells by Runx/Cbfβ binding to the Il4 silencer." J.Exp.Med. 204, 1749-1755 (2007). |
| (5) | Taniuchi, I., Osato, M., Egawa. T., Sunshine, M.J., Bae, S.-C., Komori, T., Ito, Y., and Littman, D.R.: "Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development." Cell, 111, 621-633 (2002). |