Laboratory for Cell Signaling
Research Areas
| Signaling regulation for all steps of antigen recognition, activation and development of T cells are analyzed. These include the regulation of immunological synapse, TCR signal transduction, co-stimulation regulation and signaling in T cell development. Since T cells play central roles in the regulation of immune responses and diseases, results will be utilized for immune-modulation. |  Group Director Takashi SAITO (Ph.D.)  |
Research Subjects
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List of Selected Publications
| (1) | Yamasaki, S., Matsumoto, M., Takeuchi, O., Matsuzawa, T., Ishikawa, E., Sakuma, M., Tateno, H., Uno, J., Hirabayashi, J., Mikami, Y., Takeda, K., Akira, S., and Saito, T.: "C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia." Proc. Natl. Acad. Sci. USA. 10(6): 1897-1902, (2009) |
| (2) | Yokosuka, T., Kobayashi, W., Sakata-Sogawa, K., Hashimoto-Tane, A., Dustin, M.L., Tokunaga, M., and Saito, T.: "Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters through protein kinase C θ translocation." Immunity. 29(4): 589-601, (2008) |
| (3) | Yamasaki, S., Ishikawa, E., Sakuma, M., Ogata, K., and Saito, T.: "Mincle is an ITAM-coupled activating receptor that senses damaged cells." Nat. Immunol. 9(10): 1179-1188, (2008) |
| (4) | Hara, H., Ishihara, C., Takeuchi, A., Imanishi, T., Xue, L., Morris, SW., Inui, M., Takai, T., Shibuya, A., Saijo, S., Iwakura, Y., Ohno, N., Koseki, H., Yoshida, H., Penninger, JM., and Saito, T.: "The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors." Nat. Immunol. 8(6): 619-629, (2007). |
| (5) | Yamasaki, S. and Saito, T.: "Molecular basis for pre-TCR-mediated autonomous signaling." Trends. Immunol. 28(1): 39-43, (2007). |
| (6) | Suzuki, J-i., Yamasaki, S., Wu, J., Koretzky, G.A., and Saito, T.: "The actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T-cell activation." Blood. 109(1): 168-175, (2007). |
| (7) | Saito, T. and Yokosuka, T.: "Immunological synapse and microclusters: the site for recognition and activation of T cells." Curr. Opin. Immunol. 18(3): 305-313, (2006) |
| (8) | Suzuki, N., Suzuki, S., Millar, D. G., Unno, M., Hara, H., Calzascia, T., Yamasaki, S., Yokosuka, T., Chen, N-J., Elford, A. R., Suzuki, J-I., Takeuchi, A., Mirtsos, C., Bouchard, D., Ohashi, P. S., Yeh, W-C. and Saito, T.: "A critical role for the innate immune signaling molecule IRAK-4 in T cell activation." Science 311:1927-1932, (2006). |
| (9) | Yamasaki, S., Ishikawa, E., Sakuma, M., Ogata, K., Sakata-Sogawa, K., Hiroshima, M., Wiest, D.L., Tokunaga, M., and Saito, T.: "Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development." Nat. Immunol., 7, 67-75 (2006). |
| (10) | Yokosuka, T., Sakata-Sogawa, K., Kobayashi, W., Hiroshima, M., Hashimoto-Tane, A., Tokunaga, M., Dustin, M.L., and Saito, T.: "Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of ZAP 70 and SLP-76." Nat. Immunol., 6, 1253-1262 (2005). |