Laboratory for Endocrinology and Metabolism
Laboratory Head
Shiro MAEDA (M.D., Ph.D.)
Due to the changes in a life-style, including urvan life or Western style foods, a prevalence of obesity is progressively increasing, and obesity has become a major issue in public health, medicine and the economy, because of subsequent increase of life-threatening diseases such as diabetes mellitus, stroke and coronary heart disease. Diabetic nephropathy is a leading cause of renal death, and more than ten thousands of patients are introduced to chronic renal replacement therapy due to diabetic nephropathy every year in Japan. The pathogenesis of these diseases have been thought to be multi-factorial, and genetic susceptibility is considered as an important factor for the development and the progression of obesity, diabetes and diabetic nephropathy. We are attempting to identify the gene(s) responsible for susceptibility to these diseases with a large-scale genome-wide case-control study using single nucleotide polymorphisms (SNPs). Our goal is to know the molecular mechanism of responsible gene(s) and to contribute to the advances in the prevention and the treatment of obesity, diabetes mellitus and diabetic nephropathy
- The identification of the gene conferring susceptibility to diabetic nephropathy
- The identification of the gene conferring susceptibility to type 2 diabetes
- The identification of the gene conferring susceptibility to obesity
- February 12, 2010
- New diabetic nephropathy-related gene 'ACACB' identified
- August 18, 2008
- Identification of a gene, KCNQ1, which causes adult diabetes, involved in 20 percent of Japanese adult type-II diabetes cases
- May 29, 2009
- Gene closely related to diabetes discovered!
- Simazaki, S., Kawamura, Y., Kanazawa, A., Sekine, A., Saito, S., Tsunoda, T., Koya, D., Babazono, T., Tanaka, Y., Matsuda, M., Kawai, K., Iiizumi, T., Imanishi, M., Shinosaki, T., Yanagimoto, T., Ikeda, M., Omachi, S., Kashiwagi, A., Kaku, K., Iwamoto, Y.:
"Genetic variations in the gene encoding engulfment and cell motility 1 (ELMO1) are associated with susceptibility to diabetic nephropathy"
Diabetes, 54, 1171-1178 (2005). - Kanazawa, A, Kawamura, Y, Sekine, A, Iida, A, Tsunoda, T, Kashiwagi, A, Tanaka, Y, Babazono, T, Matsuda, M, Kawai, K, Iiizumi, T, Fujioka, T, Imanishi, M, Kaku, K, Iwamoto, Y, Kawamori, R, Kikkawa, R, Nakamura, Y, Maeda, S.:
"Single Nucleotide Polymorphisms in the Gene Encoding Kruppel-like Factor 7 are Associated with Type 2 Diabetes"
Diabetokogia, 48, 1315-1322 (2005). - Maeda, S, Tsukada, S, Kanazawa, A, Sekine, A, Tsunoda, T, Koya, D, Maegawa, H, Kashiwagi, A, Babazono, T, Matsuda, M, Tanaka, Y, Fujioka, T, Hirose, H, Eguchi, T, Ohno, Y, Groves, CJ, Hattersley, AT, Hitman, GA, Walker, M, Kaku, K, Iwamoto, Y, Kawamori, R.:
"Genetic variations in the gene encoding TFAP2B are associated with type2 diabetes"
J. Hum. Genet., 50, 283-292 (2005). - Kanazawa, A., Tsukada, S., Sekine, A., Tsunoda, T., Takahashi, A., Kashiwagi, A., Tanaka, Y., Babazono, T., Matsuda, M., Kaku, K., Iwamoto, Y., Kawamori, R., Kikkawa, R., Nakamura, Y., and Maeda, S.:
"Association of the Gene Encoding Wingless-Type Mammary Tumor Virus Integration-Site Family Member 5B (WNT5B) with Type 2 Diabetes"
Am. J. Hum. Genet., 75, 832-843 (2004). - Tanaka, N., Babazono, T., Saito, S., Sekine, A., Tsunoda, T., Haneda, M., Tanaka, Y., Fujioka, T., Kaku, K., Kawamori, R., Kikkawa, R., Iwamoto, Y., Nakamura, Y., and Maeda, S.:
"The association of solute carrier family 12 (sodium/chloride) member 3 with diabetic nephropathy, identified by genome-wide analyses of SNPs"
Diabetes, 52, 2848-2853 (2003). - Kamiyama M, Kobayashi M, Araki S, Iida A, Tsunoda T, Kawai K, Imanishi M, Nomura M, Babazono T, Iwamoto Y, Kashiwagi A, Kaku K, Kawamori R, Ng DPK, Hansen T, Gaede P, Pedersen O, Nakamura Y, Maeda S.:
"Polymorphisms in the 3' UTR in the neurocalcin δ gene affect mRNA stability, and confer susceptibility to diabetic nephropathy."
Human Genetics 122; 397-407 (2007) - Unoki1 H, Takahashi A, Kawaguchi T, Hara K, Horikoshi M, Andersen G, Ng DPK, Holmkvist J, Borch-Johnsen K, Jorgensen T, Sandbaek A, Lauritzen T, Hansen T, Nurbaya S, Tsunoda T, Kubo M, Babazono T, Hirose1 H, Hayashi1 M, Iwamoto Y, Kashiwagi A, Kaku K, Kawamori R, Tai ES, Pedersen O, Kamatani N, Kadowaki T, Kikkawa R, Nakamura Y, Maeda S
"SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations."
Nat Genet 40: 1097-1102 (2008) - Omori S, Tanaka Y, Horikoshi M, Takahashi A, Hara K, Hirose H, Kashiwagi A, Kaku K, Kawamori R, Kadowaki T, Nakamura Y, Maeda S.:
"Replication study for the association of new meta-analysis derived risk loci with susceptibility to type 2 diabetes in 6,244 Japanese individuals."
Diabetologia 52:1554-1560 (2009) - Maeda S, Kobayashi M, Araki S, Babazono T, Freedman BI, Bostrom MA, Cooke JN, Toyoda M, Umezono T, Tarnow L, Hansen T, Gaede P, Jorsal A, Ng DPK, Ikeda M, Yanagimoto T, Tsunoda T, Unoki H, Kawai K, Imanishi M, Suzuki D, Shin HD, Park KS, Kashiwagi A, Iwamoto Y, Kaku K, Kawamori R, Parving HH, Bowden DW, Pedersen O, Nakamura Y.:
"A Single Nucleotide Polymorphism within the Acetyl-Coenzyme A Carboxylase Beta Gene is Associated with Proteinuria in Patients with Type 2 Diabetes."
PLoS Genetcs 6: e1000842 (2010) - Yamauchi T, Hara K, Maeda S, Yasuda K, Takahashi A, Horikoshi M, Nakamura M, Fujita H, Grarup N, Cauchi S, Ng DPK, Ma RCW, Tsunoda T, Kubo M, Watada H, Maegawa H, Okada-Iwabu M, Iwabu M, Shojima N, Shin HD, Andersen G, Witte DR, Jørgensen T, Lauritzen T, Sandbæk A, Hansen T, Ohshige T, Omori S, Saito I, Kaku K, Hirose H, So WY, Beury D, Chan JCN, Park KS, Tai ES, Ito C, Tanaka Y, Kashiwagi A, Kawamori R, Kasuga M, Frogue P, Pedersen O, Kamatani N, Nakamura Y & Kadowaki T.:
"A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A/B."
Nat Genet 42: 864-868 (2010)