Laboratory for Respiratory Diseases
Laboratory Head
Mayumi TAMARI (M.D., Ph.D.)
Our goal is to clarify the molecular mechanism of asthma, atopic dermatitis, food allergy, allergic rhinitis and COPD, to contribute to the development of the prevention and the treatment of the diseases. We try to clarify the genetic factor implicated in the etiology of the diseases by genome-wide association studies and candidate gene approach. Clinical and experimental evidence suggests important roles for danger signals in the development of allergic inflammation. Many epidemiologic studies have implicated that infections can influence both the development and the severity of allergic diseases. We have focused on the genes involved in mucosal innate immunity and infections. Several SNPs have shown significant associations with the disease susceptibility or severity, and functional analyses have been conducted. We also conduct pharmacogenetic analysis of asthma drugs.
- Genetics of allergic diseases
- Genetics of chronic obstractive lung diseases
- Genetic variants of innate immunity related genes
- Harada M, Hirota T, Jodo AI, Hitomi Y, Sakashita M, Tsunoda T, Miyagawa T, Doi S, Kameda M, Fujita K, Miyatake A, Enomoto T, Noguchi E, Masuko H, Sakamoto T, Hizawa N, Suzuki Y, Yoshihara S, Adachi M, Ebisawa M, Saito H, Matsumoto K, Nakajima T, Mathias RA, Rafaels N, Barnes KC, Himes BE, Duan QL, Tantisira KG, Weiss ST, Nakamura Y, Ziegler SF, Tamari M.
"TSLP Promoter Polymorphisms are Associated with Susceptibility to Bronchial Asthma."
Am J Respir Cell Mol Biol. 2010 in press - Harada M, Obara K, Hirota T, Yoshimoto T, Hitomi Y, Sakashita M, Doi S, Miyatake A, Fujita K, Enomoto T, Taniguchi M, Higashi N, Fukutomi Y, Nakanishi K, Nakamura Y, Tamari M.
"A functional polymorphism in IL-18 is associated with severity of bronchial asthma."
Am J Respir Crit Care Med. 180:1048-1055. (2009) - Hitomi Y, Ebisawa M, Tomikawa M, Imai T, Komata T, Hirota T, Harada M, Sakashita M, Suzuki Y, Shimojo N, Kohno Y, Fujita K, Miyatake A, Doi S, Enomoto T, Taniguchi M, Higashi N, Nakamura Y, Tamari M.
"Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma."
J Allergy Clin Immunol. 124:779-785 (2009) - Harada M, Hirota T, Jodo AI, Doi S, Kameda M, Fujita K, Miyatake A, Enomoto T, Noguchi E, Yoshihara S, Ebisawa M, Saito H, Matsumoto K, Nakamura Y, Ziegler SF, Tamari M.
"Functional analysis of the polymorphisms of the TSLP gene in human bronchial epithelial cells."
Am J Respir Cell Mol Biol. 40,368-374 (2009) - Hirota T, Harada M, Sakashita M, Doi S, Miyatake A, Fujita K, Enomoto T, Ebisawa M, Yoshihara S, Noguchi E, Saito H, Nakamura Y, Tamari M.
"Genetic polymorphism regulating ORM1-like 3 (Saccharomyces cerevisiae) expression is associated with childhood atopic asthma in a Japanese population."
J. Allergy Clin. Immunol. 121,769-770 (2008) - Sakashita M, Yoshimoto T, Hirota T, Harada M, Ohkubo K, Osawa Y, Fujieda S , Nakamura Y, Yasuda K, Nakanishi K, Tamari M.
"Association of serum IL-33 level and the IL-33 genetic variant with Japanese cedar pollinosis"
Clin Exp Allergy. 38,1875-1881 (2008)
- Mayumi TAMARI
- Laboratory Head
- Tomomitsu HIROTA