Laboratory for Digestive Diseases

Laboratory Head
Kazuaki CHAYAMA
(M.D., Ph.D.)
Effects and side effects of medical therapeutics differ among individuals because of different levels of drug absorption, metabolism and excretion rates. These different responses are largely due to genetic background. Some genetic polymorphisms including SNPs (single nucleotide polymorphisms), should be markers of these differences. In this study, we analyze SNPs that may correlate with the above effects and side effects of drugs and the effect of these SNPs on the genetic expression of genetic products. Our goals are the establishment of order-made therapeutics, the identification of new genes that are related in regard to therapeutic effects and the development of a new drug therapy.
- Identification of genes related to the effects and side effects of interferon
- Identification of genes related to the effects and side effects of anti-cancer agents
- Abe, H., Hayes, C.N., Ochi, H., Maekawa, T., Tsuge, M., Miki, D., Mitsui, F., Hiraga, N., Imamura, M., Takahashi, S., Kubo, M., Nakamura, Y., Chayama, K.:
"IL28 variation affects expression of interferon stimulated genes and peg-interferon and ribavirin therapy."
J. Hepatol. (2011) in press. - Fujimoto, Y., Ochi, H., Maekawa, T., Abe, H., Hayes, C.N., Kumada, H., Nakamura, Y., Chayama, K.:
"A single nucleotide polymorphism in activated cdc42 associated tyrosine kinase 1 influences the interferon therapy in hepatitis C patients."
J. Hepatol. (2011) in press. - Ochi, H., Maekawa, T., Abe, H., Hayashida, Y., Nakano, R., Imamura, M., Hiraga, N., Kawakami, Y., Aimitsu, S., Kao, J.H., Kubo, M., Tsunoda, T., Kumada, H., Nakamura, Y., Hayes, C.N., Chayama, K.:
"IL-28B predicts response to chronic hepatitis C therapy - fine-mapping and replication study in Asian populations."
J. Gen. Virol. (2011) in press. - Hayes, C.N., Kobayashi, M., Akuta, N., Suzuki, F., Kumada, H., Abe, H., Miki, D., Imamura, M., Ochi, H., Kamatani, N., Nakamura, Y., Chayama, K.:
"HCV substitutions and IL28B polymorphisms on outcome of peg-interferon plus ribavirin combination therapy."
Gut 60(2), 261-7 (2011). - Miki, D., Kubo, M., Takahashi, A., Yoon, K.A., Kim, J., Lee, G.K., Zo, J.I., Lee, J.S., Hosono, N., Morizono, T., Tsunoda, T., Kamatani, N., Chayama, K., Takahashi, T., Inazawa, J., Nakamura, Y., Daigo, Y.:
"Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations."
Nat. Genet. 42(10), 893-6 (2010). - Ochi, H., Maekawa, T., Abe, H., Hayashida, Y., Nakano, R., Kubo, M., Tsunoda, T., Hayes, C.N., Kumada, H., Nakamura, Y., Chayama, K.:
"ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy - a genome-wide study of Japanese HCV virus patients."
Gastroenterology 139(4), 1190-7 (2010). - Abe, H., Ochi, H., Maekawa, T., Hayes, C.N., Tsuge, M., Miki, D., Mitsui, F., Hiraga, N., Imamura, M., Takahashi, S., Ohishi, W., Arihiro, K., Kubo, M., Nakamura, Y., Chayama, K.:
"Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients."
J. Hepatol. 53(3), 439-43 (2010). - Kamatani, Y., Wattanapokayakit, S., Ochi, H., Kawaguchi, T., Takahashi, A., Hosono, N., Kubo, M., Tsunoda, T., Kamatani, N., Kumada, H., Puseenam, A., Sura, T., Daigo, Y., Chayama, K., Chantratita, W., Nakamura, Y., Matsuda, K.:
"A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians."
Nat. Genet. 41(5), 591-5 (2009). - Tsukada, H., Ochi, H., Maekawa, T., Abe, H., Fujimoto, Y., Tsuge, M., Takahashi, H., Kumada, H., Kamatani, N., Nakamura, Y., Chayama, K.:
"A polymorphism in MAPKAPK3 affects response to interferon therapy for chronic hepatitis C."
Gastroenterology 136(5), 1796-805 (2009) - Tsuge, M., Hamamoto, R., Silva, F.P., Ohnishi, Y., Chayama, K., Kamatani, N., Furukawa, Y., Nakamura, Y.:
"A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancers."
Nat. Genet. 37(10), 1104-7 (2005).
- Kazuaki CHAYAMA
- Laboratory Head
- Daiki MIKI