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Laboratory for Medical Informatics
Tatsuhiko TSUNODA
Laboratory Head
Tatsuhiko TSUNODA
(Ph.D.(Medicine) & Ph.D.(Eng.))
mail

Research Areas

Medicine, in the very near future, will be able to provide patients with optimized treatments, such as individualized dosage of drugs and therapies. Patient variability with respect to such treatment response arises from variation in both the patients' genomic DNA as well as from environmental interactions. Our research will be directed towards combining genetic factors obtained from genomic sequence variation analysis/detection with gene-expression profiles obtained from microarray experiments; the final goal being their application to diagnoses and genetic therapies. Modern medicine must strive to avoid side effects stemming from the application of inadequate therapies. Towards this goal, one of the most important contributions we could make is genome-wide association studies for identification of disease and/or drug response related genes/variation. Using next-generation sequencer data, we will/have exhaustively explored variation of individuals' genomes and alterations in cancer genomes to a high quality. We will also develop theoretical frameworks and algorithms, and their practical extensions, for handling the ever increasing genetic variation, clinical and gene expression data, investigating disease-causing genes, and clarifying disease etiology.

Research Subject

  1. Genome-wide association studies based on linkage disequilibrium and haplotype pattern analyses
  2. Theory and algorithms for association studies
  3. Analyses of copy number variations
  4. Exploration of disease-related genes based on analyses of polymorphisms, gene-expression profiles and pathways
  5. Genomic variation analysis based on next generation sequencer data

Related links

  1. RIKEN Center for Genomic Medicine Website_Laboratories PageNew Window

Press release

November 25, 2010
Whole genome sequencing of Japanese individual reveals wealth of undiscovered genetic variation
July 18, 2008
Development of a speculative methodology for the determination of the numbers of duplicated and deleted DNA sequences in chromosomes for the first time in the world

RIKEN RESEARCH

January 07,2011
Embracing our differences
The first Japanese human genome sequence suggests that genetics researchers may be overlooking rare but potentially important variations New Window
October 24, 2008
Mapping multiplicity mathematically
A new algorithm crunches genomic data to predict maps of variable chromosomal regions that may yield valuable indicators of disease susceptibility or drug responseNew Window
June 29,2006
Analysis of human chromosome 11 complete
Researchers poised to mine a rich resource of novel genes on chromosome 11. New Window

List of Selected Publications

  1. Fujimoto, A., Nakagawa, H., Hosono, N., Nakano, K., Abe, T., Boroevich, K.A., Nagasaki, M., Yamaguchi, R., Shibuya, T., Kubo, M., Miyano, S., Nakamura, Y., and Tsunoda, T.:
    "Whole genome sequencing and comprehensive variant analysis of a Japanese individual using massively parallel sequencing"
    Nature Genetics, 42, 931-936 (2010).
  2. Kato, M., Nakamura, Y., and Tsunoda, T.:
    "An Algorithm for Inferring Complex Haplotypes in a Region of Copy-Number Variation"
    American Journal of Human Genetics, 83, 157-169 (2008).
  3. Kato, M., Kawaguchi, T., Ishikawa, S., Umeda, T., Nakamichi, R., Shapero, M.H., Jones, K.W., Nakamura, Y., Aburatani, H., and Tsunoda, T.:
    "Population-genetic nature of copy number variations in the human genome"
    Human Molecular Genetics, 19, 761-773 (2010).
  4. Tsunoda, T., Lathrop, G.M., Sekine, A., Yamada, R., Takahashi, A., Ohnishi, Y., Tanaka, T., and Nakamura, Y.:
    "Variation of gene-based SNPs and linkage disequilibrium patterns in the human genome"
    Human Molecular Genetics, 13, 1623-1632 (2004).
  5. Kato, M., Miya, F., Kanemura, Y., Tanaka, T., Nakamura, Y., and Tsunoda, T.:
    "Recombination rates of genes expressed in human tissues"
    Human Molecluar Genetics, 17, 577-586 (2008).
  6. The International Cancer Genome Consortium:
    "International network of cancer genome projects"
    Nature, 464, 993-998 (2010).
  7. The International HapMap Consortium:
    "A second generation human haplotype map of over 3.1 million SNPs"
    Nature, 449, 851-862 (2007).
  8. The International HapMap Consortium:
    "A haplotype map of the human genome"
    Nature, 437, 1299-1320 (2005).
  9. Ozaki, K., Ohnishi, Y., Iida, A., Sekine, A., Yamada, R., Tsunoda, T., Sato, H., Sato, H., Hori, M., Nakamura, Y., and Tanaka, T.:
    "Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction"
    Nature Genetics, 32, 650-654 (2002).
  10. Ozaki, K., Sato, H., Inoue, K., Tsunoda, T., Sakata, Y., Mizuno, H., Lin, T., Miyamoto, Y.,.Aoki, A., Onouchi, Y., Sheu, S., Ikegawa, S., Odashiro, K., Nobuyoshi, M., Juo, S.H., Hori, M., Nakamura, Y., and Tanaka, T.:
    "SNPs in BRAP associated with risk of myocardial infarction in Asian populations"
    Nature Genetics, 41, 329-333 (2009).

Members

Tatsuhiko TSUNODA
Laboratory Head
Fuyuki MIYA
 
Yumi KABATA
 
Akihiro FUJIMOTO
 
Daichi SHIGEMIZU
 
Todd Andrew JOHNSON
 
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