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Nano Medical Engineering Laboratory
Yoshihiro ITO
Chief Scientist
Yoshihiro ITO (D.Eng.)
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Research Areas

This laboratory aims to create new functional materials by a new method which will be developed by combination of chemical and biotechnological methodology. We use organic synthetic chemistry, combinatorial chemistry, molecular engineering, polymer engineering, hybrid materials engineering, gene and protein engineering, microfabrication technology, and nanotechnology to synthesize new materials and the systems for development of regenerative medicine, artificial organs, drug delivery systems, nanomedicine, molecular imaging, biochips, bioelectronics, artificial enzymes and artificial antibodies.

Research Subject

  1. Biomaterials for regenerative medicine
  2. Nanomedicine using RNAi
  3. Development of microarray biochips
  4. Development of molecular probes for cellular imaging
  5. Development of high perfromance organic catalyst by combinatorial engineering

Related links

  1. RIKEN Advanced Science Institute Website_Laboratories PageNew Window
  2. Individual Website Laboratory PageNew Window

Press release

November 15, 2007
Nano production techniques applied to gene-switching RNA
Researchers find a means to extend the useful life of synthetic RNA that could be utilized to safely combat hereditary diseases. New Window

RIKEN RESEARCH

August 31, 2007
All-round immobilization revolutionizes medicine New Window
May 16, 2008
No loose ends
Tying short RNA molecules into loops gives them a stability boost, which could lead to more effective therapeutic strategies for modulating gene expression New Window

List of Selected Publications

  1. Ålander, J, Johansson, K, Heuser, V. D., Farebo, H., Järvliden, J., Abe, H., Shibata, A., Ito, M, Ito, Y., and Morgenstern, R.:
    "Characterisation of a new fluorogenic substrate for microsomal glutathione transferase 1."
    Anal. Biochem., 390, 52-56 (2009)
  2. Furukawa,K., Abe, H., Hibino, K., Sako, Y., Tsuneda, S., and Ito, Y.:
    "Reduction-triggered fluorescent amplification probe for detection of endogenous RNAs in living human cells."
    Bioconj. Chem., 20, 1026-1036 (2009)
  3. Liu, M., Kagahara ,T., Abe, H., and Ito,Yo.:
    "In vitro selection of hemin-binding catalytic RNA."
    Bioorg. Med. Chem. Lett., 19, 1484-1487 (2009)
  4. Kitajima. T., Hasuda, H., , Sakuragi, M., , Ozu, T., and Ito, Y.:
    "A chimeric epidermal growth factor with fibrin-affinity promotes repair injured keratinocyte sheets."
    Acta Biomater. , 5, 2623-2632 (2009)
  5. Loh, X. J., Cheong, W. C. D., Li, J., and Ito, Y.:
    "Novel poly(N-isopropylacrylamide)-poly[(R)-3-hydroxybutyrate]-poly(N-isopropylacrylamide) triblock copolymer surface as a culture substrate for human mesenchymal stem cells."
    Soft Matter, 5, 2937 - 2946 (2009)
  6. Yokota, H., Han, Y-W., Allemand, J-F., Xi, X-G., Bensimon, D., Croquette, Vincent., Ito, Y., and Harada, Y.:
    "Single-molecule visualization of binding modes of helicase to DNA on PEGylated surfaces."
    Chem. Lett., 38, 308-309 (2009)
  7. Furukawa, K., Abe ,H., Wang ,J., Uda, M., Koshino, H., Tsuneda, S., and Ito, Y.:
    "Reduction-triggered red fluorescent probes for dual-color detection of oligonucleotide sequences."
    Org. Biomol. Chem., 7, 671 - 677 (2009)
  8. Liu, M., Kagahara, T., Abe, H., and Ito, Y.:
    "Direct In Vitro Selection of Hemin-Binding DNA Aptamer with Peroxidase Activity."
    Bull. Chem. Soc. Jpn., 82, 99-104 (2009)
  9. Tsuzuki, Saki., Wada, Akira., and Ito0,Y.:
    "Photo-immobilization of biological components on gold-coated chips for measurements using surface plasmon resonance (SPR) and a quartz crystal microbalance (QCM)."
    Biotechnol. Bioeng., 102, 700-707 (2009)
  10. Sakuragi, M., Tsuzuki, S., Hasuda, H., Wada, A., Matoba, K., Kubo, I., and Ito, Y,:
    "Synthesis of a photoimmobilizable histidine polymer for surface modification."
    J. Apply. Polym. Sci., 112, 315-319 (2009)
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