研究紹介

生命医科学研究センター

国際ゲノム連携研究チーム

チームリーダー 莚田 泰誠 (Ph.D.)
莚田 泰誠 (Ph.D.)

当研究チームは、理化学研究所と海外研究機関との共同研究を通して、薬剤の副作用の予測、適正な薬剤投与、及び疾患の発症リスクの診断に有用なバイオマーカーを同定することを目指しています。また、海外から若い共同研究者を招聘し、SNPタイピングや遺伝統計学的解析・機能解析を実施することで、SNPを利用した研究に習熟してもらうことを最初のステップとし、将来的には、国際的なSNP研究ネットワークを構築し、当センターが世界におけるオーダーメイド医療実現の主導的役割を果たすことを目指します。

研究主分野

医歯薬学

キーワード

  • ファーマコゲノミクス
  • ゲノムバイオマーカー
  • 薬物応答性
  • 副作用
  • 生殖細胞系列遺伝子検査

主要論文

  1. Ruamviboonsuk P, Tadarati M, Singhanetr P, Wattanapokayakit S, Kunhapan P, Wanitchanon T, Wichukchinda N, Mushiroda T, Akiyama M, Momozawa Y, Kubo M, Mahasirimongkol S.:
    "Genome-wide association study of neovascular age-related macular degeneration in the Thai population"
    J Hum Genet. in press (2017).
  2. Petros Z, Lee MT, Takahashi A, Zhang Y, Yimer G, Habtewold A, Schuppe-Koistinen I, Mushiroda T, Makonnen E, Kubo M, Aklillu E.:
    "Genome-Wide Association and Replication Study of Hepatotoxicity Induced by Antiretrovirals Alone or with Concomitant Anti-Tuberculosis Drugs"
    OMICS 21, 207-16 (2017).
  3. Petros Z, Lee MM, Takahashi A, Zhang Y, Yimer G, Habtewold A, Amogne W, Aderaye G, Schuppe-Koistinen I, Mushiroda T, Makonnen E, Kubo M, Aklillu E.:
    "Genome-wide association and replication study of anti-tuberculosis drugs-induced liver toxicity"
    BMC Genomics 17, 755 (2016).
  4. Chin YM, Tan LP, Abdul Aziz N, Mushiroda T, Kubo M, Mohd Kornain NK, Tan GW, Khoo AS, Krishnan G, Pua KC, Yap YY, Teo SH, Lim PV, Nakamura Y, Lum CL; Malaysian NPC Study Group, Ng CC.:
    "Integrated pathway analysis of nasopharyngeal carcinoma implicates the axonemal dynein complex in the Malaysian cohort"
    Int J Cancer 139, 1731-9 (2016).
  5. Low JS, Chin YM, Mushiroda T, Kubo M, Govindasamy GK, Pua KC, Yap YY, Yap LF, Subramaniam SK, Ong CA, Tan TY, Khoo AS; Malaysian NPC Study Group, Ng CC.:
    "A Genome Wide Study of Copy Number Variation Associated with Nasopharyngeal Carcinoma in Malaysian Chinese Identifies CNVs at 11q14.3 and 6p21.3 as Candidate Loci"
    PLoS One 11, e0145774 (2016)
  6. Chin YM, Mushiroda T, Takahashi A, Kubo M, Krishnan G, Yap LF, Teo SH, Lim PV, Yap YY, Pua KC, Kamatani N, Nakamura Y, Sam CK, Khoo AS; Malaysian NPC Study Group, Ng CC.:
    "HLA-A SNPs and amino acid variants are associated with nasopharyngeal carcinoma in Malaysian Chinese"
    Int J Cancer 136, 678-87 (2015).
  7. Chen CH, Lee CS, Lee MT, Ouyang WC, Chen CC, Chong MY, Wu JY, Tan HK, Lee YC, Chuo LJ, Chiu NY, Tsang HY, Chang TJ, Lung FW, Chiu CH, Chang CH, Chen YS, Hou YM, Chen CC, Lai TJ, Tung CL, Chen CY, Lane HY, Su TP, Feng J, Lin JJ, Chang CJ, Teng PR, Liu CY, Chen CK, Liu IC, Chen JJ, Lu T, Fan CC, Wu CK, Li CF, Wang KH, Wu LS, Peng HL, Chang CP, Lu LS, Chen YT, Cheng AT; Taiwan Bipolar Consortium.:
    "Variant GADL1 and response to lithium therapy in bipolar I disorder"
    N Engl J Med 370, 119-28 (2014).
  8. Ohara M, Takahashi H, Lee MT, Wen MS, Lee TH, Chuang HP, Luo CH, Arima A, Onozuka A, Nagai R, Shiomi M, Mihara K, Morita T, Chen YT.:
    "Determinants of the over-anticoagulation response during warfarin initiation therapy in Asian patients based on population pharmacokinetic-pharmacodynamic analyses"
    PLoS One, 9, e105891 (2014).
  9. Caudle KE, Rettie AE, Whirl-Carrillo M, Smith LH, Mintzer S, Lee MT, Klein TE, Callaghan JT; Clinical Pharmacogenetics Implementation Consortium.:
    "Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP2C9 and HLA-B genotype and Phenytoin Dosing"
    Clin Pharmacol Ther 96, 542-8 (2014).
  10. Lee MT, Mahasirimongkol S, Zhang Y, Suwankesawong W, Chaikledkaew U, Pavlidis C, Patrinos GP, Chantratita W.:
    "Clinical application of pharmacogenomics: The example of HLA-based drug-induced toxicity"
    Public Health Genomics, 17, 248-55 (2014).

お問い合わせ先

〒230-0045 神奈川県横浜市鶴見区末広町1-7-22
Tel: 045-503-9597
Fax: 045-503-9568

mushiroda [at] riken.jp
※[at]は@に置き換えてください。

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