研究紹介

統合生命医科学研究センター

統計解析研究チーム

チームリーダー 鎌谷 洋一郎 (M.D., Ph.D)
鎌谷 洋一郎 (M.D., Ph.D)

当研究室はオーダーメイド医療を実現するための遺伝統計学的解析を行っています。また理研統合生命医科学研究センター(IMS)内の各チーム、及び東京大学と共同で、それらの手法を応用した解析を行っています。これまでSNPアレイデータを用いた全ゲノム関連解析(Genome-wide association study; GWAS) という手法を用いた解析を中心に行い、複雑遺伝性疾患の疾患感受性遺伝的多型ならびに、臨床検査値や体重や身長などの身体的特徴との関連へと発展させました。我々はまた、多くの国際共同研究に参加し、全世界的なゲノム研究の一部として解析を担当しています。現在はGWASを継続するほか、公開エピゲノムデータを用いたGWASシグナルの機能的意味の解釈、日本人特異的なリファレンスパネルを用いたHLA imputation解析、機械学習手法による全ゲノムエピスタシス解析、ゲノム構造多型解析、縦断的生存データを対象とした解析、ゲノム学的側面から臨床的因子の因果推論や、次世代シークエンサーの生み出す全ゲノムシークエンス(Whole genome sequence; WGS)結果をGWASと統合する解析に取り組んでいます。

研究主分野

医歯薬学

キーワード

  • ゲノムワイド関連研究
  • 全ゲノムシークエンス
  • エピスタシス解析

主要論文

  1. Akiyama M, Okada Y, Kanai M, Takahashi A, Momozawa Y, Ikeda M, Iwata N, Ikegawa S, Hirata M, Matsuda K, Iwasaki M, Yamaji T, Sawada N, Hachiya T, Tanno K, Shimizu A, Hozawa A, Minegishi N, Tsugane S, Yamamoto M, Kubo M, Kamatani Y.
    "Genome-wide association study identifies 112 new loci for body mass index in the Japanese population."
    Nat Genet. 49(10):1458-1467, (2017)
  2. Sapkota Y, Steinthorsdottir V, Morris AP, Fassbender A, Rahmioglu N, De Vivo I, Buring JE, Zhang F, Edwards TL, Jones S, O D, Peterse D, Rexrode KM, Ridker PM, Schork AJ, MacGregor S, Martin NG, Becker CM, Adachi S, Yoshihara K, Enomoto T, Takahashi A, Kamatani Y, Matsuda K, Kubo M, Thorleifsson G, Geirsson RT, Thorsteinsdottir U, Wallace LM; iPSYCH-SSI-Broad Group., Yang J, Velez Edwards DR, Nyegaard M, Low SK, Zondervan KT, Missmer SA, D'Hooghe T, Montgomery GW, Chasman DI, Stefansson K, Tung JY, Nyholt DR.
    "Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism."
    Nat Commun. 2017 May 24;8:15539.
  3. Low SK, Takahashi A, Ebana Y, Ozaki K, Christophersen IE, Ellinor PT; AFGen Consortium., Ogishima S, Yamamoto M, Satoh M, Sasaki M, Yamaji T, Iwasaki M, Tsugane S, Tanaka K, Naito M, Wakai K, Tanaka H, Furukawa T, Kubo M, Ito K, Kamatani Y, Tanaka T.
    "Identification of six new genetic loci associated with atrial fibrillation in the Japanese population."
    Nat Genet. 2017 Jun;49(6):953-958.
  4. Christophersen IE, Rienstra M, Roselli C, Yin X, Geelhoed B, Barnard J, Lin H, Arking DE, Smith AV, Albert CM, Chaffin M, Tucker NR, Li M, Klarin D, Bihlmeyer NA, Low SK, Weeke PE, Müller-Nurasyid M, Smith JG, Brody JA, Niemeijer MN, Dörr M, Trompet S, Huffman J, Gustafsson S, Schurmann C, Kleber ME, Lyytikäinen LP, Seppälä I, Malik R, Horimoto ARVR, Perez M, Sinisalo J, Aeschbacher S, Thériault S, Yao J, Radmanesh F, Weiss S, Teumer A, Choi SH, Weng LC, Clauss S, Deo R, Rader DJ, Shah SH, Sun A, Hopewell JC, Debette S, Chauhan G, Yang Q, Worrall BB, Paré G, Kamatani Y, Hagemeijer YP, Verweij N, Siland JE, Kubo M, Smith JD, Van Wagoner DR, Bis JC, Perz S, Psaty BM, Ridker PM, Magnani JW, Harris TB, Launer LJ, Shoemaker MB, Padmanabhan S, Haessler J, Bartz TM, Waldenberger M, Lichtner P, Arendt M, Krieger JE, Kähönen M, Risch L, Mansur AJ, Peters A, Smith BH, Lind L, Scott SA, Lu Y, Bottinger EB, Hernesniemi J, Lindgren CM, Wong JA, Huang J, Eskola M, Morris AP, Ford I, Reiner AP, Delgado G, Chen LY, Chen YI, Sandhu RK, Li M, Boerwinkle E, Eisele L, Lannfelt L, Rost N, Anderson CD, Taylor KD, Campbell A, Magnusson PK, Porteous D, Hocking LJ, Vlachopoulou E, Pedersen NL, Nikus K, Orho-Melander M, Hamsten A, Heeringa J, Denny JC, Kriebel J, Darbar D, Newton-Cheh C, Shaffer C, Macfarlane PW, Heilmann-Heimbach S, Almgren P, Huang PL, Sotoodehnia N, Soliman EZ, Uitterlinden AG, Hofman A, Franco OH, Völker U, Jöckel KH, Sinner MF, Lin HJ, Guo X; METASTROKE Consortium of the ISGC.; Neurology Working Group of the CHARGE Consortium., Dichgans M, Ingelsson E, Kooperberg C, Melander O, Loos RJF, Laurikka J, Conen D, Rosand J, van der Harst P, Lokki ML, Kathiresan S, Pereira A, Jukema JW, Hayward C, Rotter JI, März W, Lehtimäki T, Stricker BH, Chung MK, Felix SB, Gudnason V, Alonso A, Roden DM, Kääb S, Chasman DI, Heckbert SR, Benjamin EJ, Tanaka T, Lunetta KL, Lubitz SA, Ellinor PT; AFGen Consortium.
    "Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation."
    Nat Genet. 2017 Jun;49(6):946-952.
  5. van Rooij FJ, Qayyum R, Smith AV, Zhou Y, Trompet S, Tanaka T, Keller MF, Chang LC, Schmidt H, Yang ML, Chen MH, Hayes J, Johnson AD, Yanek LR, Mueller C, Lange L, Floyd JS, Ghanbari M, Zonderman AB, Jukema JW, Hofman A, van Duijn CM, Desch KC, Saba Y, Ozel AB, Snively BM, Wu JY, Schmidt R, Fornage M, Klein RJ, Fox CS, Matsuda K, Kamatani N, Wild PS, Stott DJ, Ford I, Slagboom PE, Yang J, Chu AY, Lambert AJ, Uitterlinden AG, Franco OH, Hofer E, Ginsburg D, Hu B, Keating B, Schick UM, Brody JA, Li JZ, Chen Z, Zeller T, Guralnik JM, Chasman DI, Peters LL, Kubo M, Becker DM, Li J, Eiriksdottir G, Rotter JI, Levy D, Grossmann V, Patel KV, Chen CH; BioBank Japan Project., Ridker PM, Tang H, Launer LJ, Rice KM, Li-Gao R, Ferrucci L, Evans MK, Choudhuri A, Trompouki E, Abraham BJ, Yang S, Takahashi A, Kamatani Y, Kooperberg C, Harris TB, Jee SH, Coresh J, Tsai FJ, Longo DL, Chen YT, Felix JF, Yang Q, Psaty BM, Boerwinkle E, Becker LC, Mook-Kanamori DO, Wilson JG, Gudnason V, O'Donnell CJ, Dehghan A, Cupples LA, Nalls MA, Morris AP, Okada Y, Reiner AP, Zon LI, Ganesh SK.
    "Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis."
    Am J Hum Genet. 2017 Jan 5;100(1):51-63.
  6. Mahajan A, Rodan AR, Le TH, Gaulton KJ, Haessler J, Stilp AM, Kamatani Y, Zhu G, Sofer T, Puri S, Schellinger JN, Chu PL, Cechova S, van Zuydam N; SUMMIT Consortium.; BioBank Japan Project., Arnlov J, Flessner MF, Giedraitis V, Heath AC, Kubo M, Larsson A, Lindgren CM, Madden PA, Montgomery GW, Papanicolaou GJ, Reiner AP, Sundström J, Thornton TA, Lind L, Ingelsson E, Cai J, Martin NG, Kooperberg C, Matsuda K, Whitfield JB, Okada Y, Laurie CC, Morris AP, Franceschini N.
    "Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity."
    Am J Hum Genet. 2016 Sep 1;99(3):636-46.
  7. Peter K. Joshi, Tonu Esko, Hannele Mattsson, Niina Eklund, Ilaria Gandin, Teresa Nutile, Anne U. Jackson, Claudia Schurmann, Albert V. Smith, Weihua Zhang, Yukinori Okada, Alena Stancˇa´kova´, Jessica D. Faul, Wei Zhao, Traci M. Bartz, Maria Pina Concas, Nora Franceschini, Stefan Enroth, Veronique Vitart, Stella Trompet, Xiuqing Guo, Daniel I. Chasman, Jeffery R. O’Connel, Tanguy Corre, Suraj S. Nongmaithem, Yuning Chen, Massimo Mangino, Daniela Ruggiero, Michela Traglia, Aliki-Eleni Farmaki, Tim Kacprowski, Andrew Bjonnes, Ashley van der Spek, Ying Wu, Anil K. Giri, Lisa R. Yanek, Lihua Wang, Edith Hofer, Cornelius A. Rietveld, Olga McLeod, Marilyn C. Cornelis, Cristian Pattaro, Niek Verweij, Clemens Baumbach, Abdel Abdellaoui, Helen R. Warren, Dragana Vuckovic, Hao Mei, Claude Bouchard, John R. B. Perry, Stefania Cappellani, Saira S. Mirza, Miles C. Benton, Ulrich Broecke, Sarah E. Medland, Penelope A. Lind, Giovanni Malerba, Alexander Drong, Loic Yengo, Lawrence F. Bielak, Degui Zhi, Peter J. van der Most, Daniel Shriner, Reedik Ma¨ gi, Gibran Hemani, Tugce Karaderi, Zhaoming Wang, Tian Liu, Ilja Demuth, Jing Hua Zhao, Weihua Meng, Lazaros Lataniotis, Sander W. van der Laan, Jonathan P. Bradfield, Andrew R. Wood, Amelie Bonnefond, Tarunveer S. Ahluwalia, Leanne M. Hall, Erika Salvi, Seyhan Yazar, Lisbeth Carstensen, Hugoline G. de Haan, Mark Abney, Uzma Afza, Matthew A. Allison, Najaf Amin, Folkert W. Asselbergs, Stephan J. L. Bakker, R. Graham Barr, Sebastian E. Baumeister, Daniel J. Benjamin, Sven Bergmann, Eric Boerwinkle, Erwin P. Bottinger, Archie Campbell, Aravinda Chakravarti, Yingleong Chan, Stephen J. Chanock, Constance Chen, Y. -D. Ida Chen, Francis S. Collins, John Connell, Adolfo Correa, L. Adrienne Cupples, George Davey Smith, Gail Davies, Marcus Do¨ rr1, Georg Ehret, Stephen B. Ellis1, Bjarke Feenstra, Mary F. Feitosa, Ian Ford, Caroline S. Fox, Timothy M. Frayling, Nele Friedrich, Frank Geller, Generation Scotland, Irina Gillham-Nasenya, Omri Gottesman11, Misa Graff, Francine Grodstein, Charles Gu, Chris Haley, Christopher J. Hammond, Sarah E. Harris, Tamara B. Harris, Nicholas D. Hastie, Nancy L. Heard-Costa, Kauko Heikkila¨, Lynne J. Hocking, Georg Homuth, Jouke-Jan Hottenga, Jinyan Huang, Jennifer E. Huffman, Pirro G. Hysi, M. Arfan Ikram, Erik Ingelsson, Anni Joensuu, A ̊ sa Johansson, Pekka Jousilahti, J. Wouter Jukema, Mika Ka ̈ ho ̈ nen, Yoichiro Kamatani, Stavroula Kanoni, Shona M. Kerr, Nazir M. Khan, Philipp Koellinger, Heikki A. Koistinen, Manraj K. Kooner, Michiaki Kubo, Johanna Kuusisto, Jari Lahti, Lenore J. Launer, Rodney A. Lea, Benjamin Lehne, Terho Lehtima ̈ki, David C.M. Liewald, Lars Lind, Marie Loh, Marja-Liisa Lokki, Stephanie J. London, Stephanie J. Loomis, Anu Loukola, Yingchang Lu, Thomas Lumley, Annamari Lundqvist, Satu Ma¨nnisto¨, Pedro Marques-Vidal, Corrado Masciullo, Angela Matchan, Rasika A. Mathias, Koichi Matsuda, James B. Meigs, Christa Meisinger, Thomas Meitinger, Cristina Menni, Frank D. Mentch, Evelin Mihailov, Lili Milani, May E. Montasser, Grant W. Montgomery, Alanna Morrison, Richard H. Myers, Rajiv Nadukuru, Pau Navarro, Mari Nelis, Markku S. Nieminen, Ilja M. Nolte, George T. O’Connor, Adesola Ogunniyi, Sandosh Padmanabhan, Walter R. Palmas, James S. Pankow, Inga Patarcic, Francesca Pavani, Patricia A. Peyser, Kirsi Pietilainen, Neil Poulter, Inga Prokopenko, Sarju Ralhan, Paul Redmond, Stephen S. Rich, Harri Rissanen, Antonietta Robino, Lynda M. Rose, Richard Rose, Cinzia Sala, Babatunde Salako, Veikko Salomaa, Antti-Pekka Sarin, Richa Saxena, Helena Schmidt, Laura J. Scott, William R. Scott, Bengt Sennblad, Sudha Seshadri, Peter Sever, Smeeta Shrestha, Blair H. Smith, Jennifer A. Smith, Nicole Soranzo, Nona Sotoodehnia, Lorraine Southam, Alice V. Stanton, Maria G. Stathopoulou, Konstantin Strauch, Rona J. Strawbridge, Matthew J. Suderman, Nikhil Tandon, Sian-Tsun Tang, Kent D. Taylor, Bamidele O. Tayo, Anna Maria To¨glhofer, Maciej Tomaszewski, Natalia Tsˇernikova, Jaakko Tuomilehto, Andre G. Uitterlinden, Dhananjay Vaidya, Astrid van Hylckama Vlieg, Jessica van Setten, Tuula Vasankari, Sailaja Vedantam, Efthymia Vlachopoulou, Diego Vozzi, Eero Vuoksimaa, Melanie Waldenberger, Erin B. Ware, William Wentworth-Shields, John B. Whitfield, Sarah Wild1, Gonneke Willemsen, Chittaranjan S. Yajnik, Jie Yao, Gianluigi Zaza, Xiaofeng Zhu, The BioBank Japan Project, Rany M. Salem, Mads Melbye, Hans Bisgaard, Nilesh J. Samani, Daniele Cusi, David A. Mackey, Richard S. Cooper, Philippe Frogue, Gerard Pasterkamp, Struan F.A. Grant, Hakon Hakonarson, Luigi Ferrucci, Robert A. Scott, Andrew D. Morris, Colin N. A. Palmer, George Dedoussis, Panos Deloukas, Lars Bertram, Ulman Lindenberger, Sonja I. Berndt, Cecilia M. Lindgren, Nicholas J. Timpson, Anke To¨njes, Patricia B. Munroe, Thorkild I. A. Sørensen, Charles N. Rotimi, Donna K. Arnett, Albertine J. Oldehinkel, Sharon L. R. Kardia, Beverley Balkau, Giovanni Gambaro, Andrew P. Morris, Johan G. Eriksson, Margie J. Wright, Nicholas G. Martin, Steven C. Hunt, John M. Starr1, Ian J. Deary, Lyn R. Griffiths, Henning Tiemeier, Nicola Pirastu, Jaakko Kaprio, Nicholas J. Wareham, Louis Pe´russe, James G. Wilson, Giorgia Girotto, Mark J. Caulfield, Olli Raitakari, Dorret I. Boomsma, Christian Gieger, Pim van der Harst, Andrew A. Hicks, Peter Kraft, Juha Sinisalo, Paul Knekt, Magnus Johannesson, Patrik K. E. Magnusson, Anders Hamsten, Reinhold Schmidt, Ingrid B. Borecki, Erkki Vartiainen, Diane M. Becker, Dwaipayan Bharadwaj, Karen L. Mohlke, Michael Boehnke, Cornelia M. van Duijn, Dharambir K. Sanghera, Alexander Teumer, Eleftheria Zeggini, Andres Metspalu, Paolo Gasparini, Sheila Ulivi, Carole Ober, Daniela Toniolo, Igor Rudan1, David J. Porteous, Marina Ciullo, Tim D. Spector, Caroline Hayward, Jose´e Dupuis, Ruth J. F. Loos, Alan F. Wright, Giriraj R. Chandak, Peter Vollenweider, Alan Shuldiner, Paul M. Ridker, Jerome I. Rotter, Naveed Sattar, Ulf Gyllensten, Kari E. North, Mario Pirastu, Bruce M. Psaty, David R. Weir, Markku Laakso, Vilmundur Gudnason, Atsushi Takahashi, John C. Chambers, Jaspal S. Kooner, David P. Strachan, Harry Campbell, Joel N. Hirschhorn, Markus Perola, Ozren Polasˇek* & James F. Wilson.:
    "Directional dominance on stature and cognition in diverse human populations"
    Nature doi:10.1038. in press
  8. Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, Croteau-Chonka DC, Esko T, Fall T, Ferreira T, Gustafsson S, Kutalik Z, Luan J, Mägi R, Randall JC, Winkler TW, Wood AR, Workalemahu T, Faul JD, Smith JA, Hua Zhao J, Zhao W, Chen J, Fehrmann R, Hedman ÅK, Karjalainen J, Schmidt EM, Absher D, Amin N, Anderson D, Beekman M, Bolton JL, Bragg-Gresham JL, Buyske S, Demirkan A, Deng G, Ehret GB, Feenstra B, Feitosa MF, Fischer K, Goel A, Gong J, Jackson AU, Kanoni S, Kleber ME, Kristiansson K, Lim U, Lotay V, Mangino M, Mateo Leach I, Medina-Gomez C, Medland SE, Nalls MA, Palmer CD, Pasko D, Pechlivanis S, Peters MJ, Prokopenko I, Shungin D, Stančáková A, Strawbridge RJ, Ju Sung Y, Tanaka T, Teumer A, Trompet S, van der Laan SW, van Setten J, Van Vliet-Ostaptchouk JV, Wang Z, Yengo L, Zhang W, Isaacs A, Albrecht E, Ärnlöv J, Arscott GM, Attwood AP, Bandinelli S, Barrett A, Bas IN, Bellis C, Bennett AJ, Berne C, Blagieva R, Blüher M, Böhringer S, Bonnycastle LL, Böttcher Y, Boyd HA, Bruinenberg M, Caspersen IH, Ida Chen YD, Clarke R, Daw EW, de Craen AJ, Delgado G, Dimitriou M, Doney AS, Eklund N, Estrada K, Eury E, Folkersen L, Fraser RM, Garcia ME, Geller F, Giedraitis V, Gigante B, Go AS, Golay A, Goodall AH, Gordon SD, Gorski M, Grabe HJ, Grallert H, Grammer TB, Gräßler J, Grönberg H, Groves CJ, Gusto G, Haessler J, Hall P, Haller T, Hallmans G, Hartman CA, Hassinen M, Hayward C, Heard-Costa NL, Helmer Q, Hengstenberg C, Holmen O, Hottenga JJ, James AL, Jeff JM, Johansson Å, Jolley J, Juliusdottir T, Kinnunen L, Koenig W, Koskenvuo M, Kratzer W, Laitinen J, Lamina C, Leander K, Lee NR, Lichtner P, Lind L, Lindström J, Sin Lo K, Lobbens S, Lorbeer R, Lu Y, Mach F, Magnusson PK, Mahajan A, McArdle WL, McLachlan S, Menni C, Merger S, Mihailov E, Milani L, Moayyeri A, Monda KL, Morken MA, Mulas A, Müller G, Müller-Nurasyid M, Musk AW, Nagaraja R, Nöthen MM, Nolte IM, Pilz S, Rayner NW, Renstrom F, Rettig R, Ried JS, Ripke S, Robertson NR, Rose LM, Sanna S, Scharnagl H, Scholtens S, Schumacher FR, Scott WR, Seufferlein T, Shi J, Vernon Smith A, Smolonska J, Stanton AV, Steinthorsdottir V, Stirrups K, Stringham HM, Sundström J, Swertz MA, Swift AJ, Syvänen AC, Tan ST, Tayo BO, Thorand B, Thorleifsson G, Tyrer JP, Uh HW, Vandenput L, Verhulst FC, Vermeulen SH, Verweij N, Vonk JM, Waite LL, Warren HR, Waterworth D, Weedon MN, Wilkens LR, Willenborg C, Wilsgaard T, Wojczynski MK, Wong A, Wright AF, Zhang Q; LifeLines Cohort Study, Brennan EP, Choi M, Dastani Z, Drong AW, Eriksson P, Franco-Cereceda A, Gådin JR, Gharavi AG, Goddard ME, Handsaker RE, Huang J, Karpe F, Kathiresan S, Keildson S, Kiryluk K, Kubo M, Lee JY, Liang L, Lifton RP, Ma B, McCarroll SA, McKnight AJ, Min JL, Moffatt MF, Montgomery GW, Murabito JM, Nicholson G, Nyholt DR, Okada Y, Perry JR, Dorajoo R, Reinmaa E, Salem RM, Sandholm N, Scott RA, Stolk L, Takahashi A, Tanaka T, Van't Hooft FM, Vinkhuyzen AA, Westra HJ, Zheng W, Zondervan KT; ADIPOGen Consortium; AGEN-BMI Working Group; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GLGC; ICBP; MAGIC Investigators; MuTHER Consortium; MIGen Consortium; PAGE Consortium; ReproGen Consortium; GENIE Consortium; International Endogene Consortium, Heath AC, Arveiler D, Bakker SJ, Beilby J, Bergman RN, Blangero J, Bovet P, Campbell H, Caulfield MJ, Cesana G, Chakravarti A, Chasman DI, Chines PS, Collins FS, Crawford DC, Cupples LA, Cusi D, Danesh J, de Faire U, den Ruijter HM, Dominiczak AF, Erbel R, Erdmann J, Eriksson JG, Farrall M, Felix SB, Ferrannini E, Ferrières J, Ford I, Forouhi NG, Forrester T, Franco OH, Gansevoort RT, Gejman PV, Gieger C, Gottesman O, Gudnason V, Gyllensten U, Hall AS, Harris TB, Hattersley AT, Hicks AA, Hindorff LA, Hingorani AD, Hofman A, Homuth G, Hovingh GK, Humphries SE, Hunt SC, Hyppönen E, Illig T, Jacobs KB, Jarvelin MR, Jöckel KH, Johansen B, Jousilahti P, Jukema JW, Jula AM, Kaprio J, Kastelein JJ, Keinanen-Kiukaanniemi SM, Kiemeney LA, Knekt P, Kooner JS, Kooperberg C, Kovacs P, Kraja AT, Kumari M, Kuusisto J, Lakka TA, Langenberg C, Le Marchand L, Lehtimäki T, Lyssenko V, Männistö S, Marette A, Matise TC, McKenzie CA, McKnight B, Moll FL, Morris AD, Morris AP, Murray JC, Nelis M, Ohlsson C, Oldehinkel AJ, Ong KK, Madden PA, Pasterkamp G, Peden JF, Peters A, Postma DS, Pramstaller PP, Price JF, Qi L, Raitakari OT, Rankinen T, Rao DC, Rice TK, Ridker PM, Rioux JD, Ritchie MD, Rudan I, Salomaa V, Samani NJ, Saramies J, Sarzynski MA, Schunkert H, Schwarz PE, Sever P, Shuldiner AR, Sinisalo J, Stolk RP, Strauch K, Tönjes A, Trégouët DA, Tremblay A, Tremoli E, Virtamo J, Vohl MC, Völker U, Waeber G, Willemsen G, Witteman JC, Zillikens MC, Adair LS, Amouyel P, Asselbergs FW, Assimes TL, Bochud M, Boehm BO, Boerwinkle E, Bornstein SR, Bottinger EP, Bouchard C, Cauchi S, Chambers JC, Chanock SJ, Cooper RS, de Bakker PI, Dedoussis G, Ferrucci L, Franks PW, Froguel P, Groop LC, Haiman CA, Hamsten A, Hui J, Hunter DJ, Hveem K, Kaplan RC, Kivimaki M, Kuh D, Laakso M, Liu Y, Martin NG, März W, Melbye M, Metspalu A, Moebus S, Munroe PB, Njølstad I, Oostra BA, Palmer CN, Pedersen NL, Perola M, Pérusse L, Peters U, Power C, Quertermous T, Rauramaa R, Rivadeneira F, Saaristo TE, Saleheen D, Sattar N, Schadt EE, Schlessinger D, Slagboom PE, Snieder H, Spector TD, Thorsteinsdottir U, Stumvoll M, Tuomilehto J, Uitterlinden AG, Uusitupa M, van der Harst P, Walker M, Wallaschofski H, Wareham NJ, Watkins H, Weir DR, Wichmann HE, Wilson JF, Zanen P, Borecki IB, Deloukas P, Fox CS, Heid IM, O'Connell JR, Strachan DP, Stefansson K, van Duijn CM, Abecasis GR, Franke L, Frayling TM, McCarthy MI, Visscher PM, Scherag A, Willer CJ, Boehnke M, Mohlke KL, Lindgren CM, Beckmann JS, Barroso I, North KE, Ingelsson E, Hirschhorn JN, Loos RJ, Speliotes EK.:
    "Genetic studies of body mass index yield new insights for obesity biology"
    Nature. 2015;518(7538):197-206
  9. Okada Y, Momozawa Y, Ashikawa K, Kanai M, Matsuda K, Kamatani Y, Takahashi A, Kubo M.:
    "Construction of a population-specific HLA imputation reference panel and its application to Graves' disease risk in Japanese"
    Nat Genet. 2015 Jun 1. doi: 10.1038/ng.3310. [Epub ahead of print]
  10. Debette S, Kamatani Y, Metso TM, Kloss M, Chauhan G, Engelter ST, Pezzini A, Thijs V, Markus HS, Dichgans M, Wolf C, Dittrich R, Touzé E, Southerland AM, Samson Y, Abboud S, Béjot Y, Caso V, Bersano A, Gschwendtner A, Sessa M, Cole J, Lamy C, Medeiros E, Beretta S, Bonati LH, Grau AJ, Michel P, Majersik JJ, Sharma P, Kalashnikova L, Nazarova M, Dobrynina L, Bartels E, Guillon B, van den Herik EG, Fernandez-Cadenas I, Jood K, Nalls MA, De Leeuw FE, Jern C, Cheng YC, Werner I, Metso AJ, Lichy C, Lyrer PA, Brandt T, Boncoraglio GB, Wichmann HE, Gieger C, Johnson AD, Böttcher T, Castellano M, Arveiler D, Ikram MA, Breteler MM, Padovani A, Meschia JF, Kuhlenbäumer G, Rolfs A, Worrall BB; International Stroke Genetics Consortium, Ringelstein EB, Zelenika D, Tatlisumak T, Lathrop M, Leys D; the CADISP group, Amouyel P, Dallongeville J.:
    "Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection"
    Nat Genet 2014; 47: 78-83.

メンバーリスト

主宰者

鎌谷 洋一郎
チームリーダー

メンバー

小杉 俊一
研究員
石垣 和慶
特別研究員
的場 奈々
特別研究員
秋山 雅人
リサーチアソシエイト

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