研究紹介

生命医科学研究センター

ゲノム解析応用研究チーム

チームリーダー 寺尾 知可史 (M.D., Ph.D)
寺尾 知可史 (M.D., Ph.D)

当研究チームは臨床応用を目標に自己免疫性疾患、血液疾患、悪性腫瘍を代表に幅広い疾患や形質を対象として、遺伝統計学・ゲノム疫学・機械学習(主に深層学習)のアプローチを用いてゲノム解析を行っています。 定性的・定量的に決定されたDNA・RNA配列、SNP/SNVや構造多型を代表とした遺伝多型、エピゲノムなどのゲノム情報とそれらの解析から得られる膨大かつ多層的な情報をゲノム以外の情報と統合し、疾病や形質のメカニズムの解明・マネジメントの改善・治療法の開発へとつなげ、患者さんや社会に還元することを目指します。

研究主分野

医歯薬学

研究関連分野

生物学

人類遺伝学 / 遺伝・染色体動態 / 疫学・予防医学

キーワード

  • 遺伝学
  • トランスレーショナルリサーチ
  • 応用遺伝学
  • 統計遺伝学
  • 機械学習・深層学習

主要論文

「*」は、理研外のみでの成果です。
  1. Akizuki S, Ishigaki K, Kochi Y, Law SM, Matsuo K, Ohmura K, Suzuki A, Nakayama M, Iizuka Y, Koseki H, Ohara O, Hirata J, Kamatani Y, Matsuda F, Sumida T, Yamamoto K, Okada Y, Mimori T, Terao C*.:
    "PLD4 is a genetic determinant to systemic lupus erythematosus and involved in murine autoimmune-phenotypes."
    Ann Rheum Dis. 2019 (in press)
  2. Terao C*, Yoshifuji H, Matsumura T, Naruse TK, Ishii T, Nakaoka Y, Kirino Y, Matsuo K, Origuchi T, Shimizu M, Maejima Y, Amiya E, Tamura N, Kawaguchi T, Takahashi M, Setoh K, Ohmura K, Watanabe R, Horita T, Atsumi T, Matsukura M, Miyata T, Kochi Y, Suda T, Tanemoto K, Meguro A, Okada Y, Ogimoto A, Yamamoto M, Takahashi H, Nakayamada S, Saito K, Kuwana M, Mizuki N, Tabara Y, Ueda A, Komuro I, Kimura A, Isobe M, Mimori T, Matsuda F.:
    "Genetic determinants and an epistasis of LILRA3 and HLA-B*52 in Takayasu arteritis."
    Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):13045-13050.
  3. Tsuji H, Ikari K, Ohmura K, Yano K, Furu M, Hashimoto M, Ito H, Fujii T, Yamamoto W, Taniguchi A, Yamanaka H, Mimori T, Terao C*.:
    "A significant joint-destructive association of HLA-DRB1*04:05 independent of DAS28 in rheumatoid arthritis."
    Ann Rheum Dis. 2019 Feb;78(2):284-286.
  4. *Terao C*, Okada Y, Ikari K, Kochi Y, Suzuki A, Ohmura K, Matsuo K, Taniguchi A, Kubo M, Raychaudhuri S, Yamamoto K, Yamanaka H, Kamatani Y, Mimori T, Matsuda F.:
    "Genetic landscape of interactive effects of HLA-DRB1 alleles on susceptibility to ACPA(+) rheumatoid arthritis and ACPA levels in Japanese population."
    J Med Genet. 2017 Dec;54(12):853-858.
  5. *Murata K, Fang C, Terao C, Giannopoulou EG, Lee YJ, Lee MJ, Mun SH, Bae S, Qiao Y, Yuan R, Furu M, Ito H, Ohmura K, Matsuda S, Mimori T, Matsuda F, Park-Min KH, Ivashkiv LB.:
    "Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis."
    Immunity. 2017 Jul 18;47(1):66-79.e5.
  6. *Terao C*, Kawaguchi T, Dieude P, Varga J, Kuwana M, Hudson M, Kawaguchi Y, Matucci-Cerinic M, Ohmura K, Riemekasten G, Kawasaki A, Airo P, Horita T, Oka A, Hachulla E, Yoshifuji H, Caramaschi P, Hunzelmann N, Baron M, Atsumi T, Hassoun P, Torii T, Takahashi M, Tabara Y, Shimizu M, Tochimoto A, Ayuzawa N, Yanagida H, Furukawa H, Tohma S, Hasegawa M, Fujimoto M, Ishikawa O, Yamamoto T, Goto D, Asano Y, Jinnin M, Endo H, Takahashi H, Takehara K, Sato S, Ihn H, Raychaudhuri S, Liao K, Gregersen P, Tsuchiya N, Riccieri V, Melchers I, Valentini G, Cauvet A, Martinez M, Mimori T, Matsuda F, Allanore Y.:
    "Trans-ethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis."
    Ann Rheum Dis. 2017 Jun;76(6):1150-1158.
  7. *Terao C*, Yoshifuji H, Nakajima T, Yukawa N, Matsuda F, Mimori T.:
    "Ustekinumab as a therapeutic option for Takayasu arteritis: from genetic findings to clinical application."
    Scand J Rheumatol. 2016 Jan:45 (1), 80-82.
  8. *Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, Graham RR, Manoharan A, Ortmann W, Bhangale T, Denny JC, Carroll RJ, Eyler AE, Greenberg JD, Kremer JM, Pappas DA, Jiang L, Yin J, Ye L, Su DF, Yang J, Xie G, Keystone E, Westra HJ, Esko T, Metspalu A, Zhou X, Gupta N, Mirel D, Stahl EA, Diogo D, Cui J, Liao K, Guo MH, Myouzen K, Kawaguchi T, Coenen MJ, van Riel PL, van de Laar MA, Guchelaar HJ, Huizinga TW, Dieude P, Mariette X, Louis Bridges Jr S, Zhernakova A, Toes RE, Tak PP, Miceli-Richard C, Bang SY, Lee HS, Martin J, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Rantapaa-Dahlqvist S, Arlestig L, Choi HK, Kamatani Y, Galan P, Lathrop M; the RACI consortium; the GARNET consortium, Eyre S, Bowes J, Barton A, de Vries N, Moreland LW, Criswell LA, Karlson EW, Taniguchi A, Yamada R, Kubo M, Liu JS, Bae SC, Worthington J, Padyukov L, Klareskog L, Gregersen PK, Raychaudhuri S, Stranger BE, De Jager PL, Franke L, Visscher PM, Brown MA, Yamanaka H, Mimori T, Takahashi A, Xu H, Behrens TW, Siminovitch KA, Momohara S, Matsuda F, Yamamoto K, Plenge RM.:
    "Genetics of rheumatoid arthritis contributes to biology and drug discovery."
    Nature. 2014 Feb 20;506(7488):376-381.
  9. *Terao C*, Yoshifuji H, Kimura A, Matsumura T, Ohmura K, Takahashi M, Shimizu M, Kawaguchi T, Chen Z, Naruse TK, Sato-Otsubo A, Ebana Y, Maejima Y, Kinoshita H, Murakami K, Kawabata D, Wada Y, Narita I, Tazaki J, Kawaguchi Y, Yamanaka H, Yurugi K, Miura Y, Maekawa T, Ogawa S, Komuro I, Nagai R, Yamada R, Tabara Y, Isobe M, Mimori T, Matsuda F.:
    "Two Susceptibility Loci to Takayasu Arteritis Reveal a Synergistic Role of the IL12B and HLA-B Regions in a Japanese Population."
    Am J Hum Genet. 2013;93(2):289-97.
  10. *Okada Y, Terao C(co-first), Ikari K, Kochi Y, Ohmura K, Suzuki A, Kawaguchi T, Stahl EA, Kurreeman FA, Nishida N, Ohmiya H, Myouzen K, Takahashi M, Sawada T, Nishioka Y, Yukioka M, Matsubara T, Wakitani S, Teshima R, Tohma S, Takasugi K, Shimada K, Murasawa A, Honjo S, Matsuo K, Tanaka H, Tajima K, Suzuki T, Iwamoto T, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Gregersen PK, Padyukov L, Worthington J, Siminovitch KA, Lathrop M, Taniguchi A, Takahashi A, Tokunaga K, Kubo M, Nakamura Y, Kamatani N, Mimori T, Plenge RM, Yamanaka H, Momohara S, Yamada R, Matsuda F, Yamamoto K.:
    "Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population."
    Nat Genet. 2012;44(5):51

メンバーリスト

主宰者

寺尾 知可史
チームリーダー

メンバー

小杉 俊一
研究員
小井土 大
特別研究員

お問い合わせ先

〒230-0045
神奈川県横浜市鶴見区末広町1-7-22 東棟3F
Tel: 045-503-9553
Fax: 045-503-9113

chikashi.terao [at] riken.jp
※[at]は@に置き換えてください。

最新の研究成果

2019年6月14日: 報道発表資料
構造多型検出アルゴリズムの包括的評価