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RIKEN Center for Biosystems Dynamics Research Laboratory for Cellular Function Imaging

Team Leader: Yosky Kataoka (M.D., Ph.D.)

Research Summary

Yosky  Kataoka(M.D., Ph.D.)

We are investigating physiological or pathological roles of cells functioning in living tissues by using in vivo imaging methods including PET, MRI, fluorescence/bioluminescence imaging, microendoscope imaging, electron microscope imaging. In particular, we aim to establish new strategies for treating neurological disorders or malignancy by imaging stem/progenitor cells in the central nervous system or cancer/cancer stem cells. Further, we study metabolic dynamics in pathophysiological states including fatigue, and develop new techniques for controlling the living systems.

Main Research Fields

  • Medicine, Dentistry & Pharmacy

Related Research Fields

  • Biological Sciences
  • Biology


  • Neuroscience
  • Fatigue
  • Neuroinflammation
  • Aging
  • Stem cell

Selected Publications

  • 1.Kume S, Nishimura Y, Mizuno K, Sakimoto N, Hori H, Tamura Y, Yamato M, Mitsuhashi R, Akiba K, Koizumi J, Watanabe Y, Kataoka Y.:
    "Music improves subjective feelings leading to cardiac autonomic nervous modulation: A pilot study."
    Front Neurosci, 11: Article 108 (2017).
  • 2.Nakano M, Tamura Y, Yamato M, Kume S, Eguchi A, Takata K, Watanabe Y, Kataoka Y.:
    "NG2 glial cells regulate neuroimmunological responses to maintain neuronal function and survival."
    Sci Rep, 7: 42041 (2017).
  • 3.Tamura Y, Kataoka Y.:
    "PET imaging of neurogenic activity in the adult brain: Toward in vivo imaging of human neurogenesis."
    Neurogenesis, 4: e1281861 (2017).
  • 4.Yamano E, Sugimoto M, Hirayama A, Kume S, Yamato M, Jin G, Tajima S, Goda N, Iwai K, Fukuda S, Yamaguti K, Kuratsune H, Soga T, Watanabe Y, Kataoka Y.:
    "Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles."
    Sci Rep, 6: 34990 (2016).
  • 5.Tamura Y, Takahashi K, Takata K, Eguchi A, Yamato M, Kume S, Nakano M, Watanabe Y, Kataoka, Y.:
    "Noninvasive evaluation of cellular proliferative activity in brain neurogenic regions in rats under depression and the treatment by enhanced [18F]FLT PET imaging."
    J Neurosci, 36: 8123-8131 (2016).
  • 6.Iwawaki T, Akai R, Oikawa D, Toyoshima T, Yoshino M, Suzuki M, Takeda N, Ishikawa T, Kataoka Y, Yamamura K.
    "Transgenic mouse model for imaging of interleukin-1β-related inflammation in vivo."
    Sci Rep, 5: 17205 (2015).
  • 7.Kume, S., Yamato, M., Tamura, Y., Jin, G., Nakano, M., Miyashige, Y., Eguchi, A., Ogata, Y., Goda, N., Iwai, K., Yamano, E., Watanabe, Y., Soga, T., and Kataoka, Y.:
    "Potential biomarkers of fatigue identified by plasma metabolome analysis in rats."
    PLOS ONE, 10: e0120106 (2015).
  • 8.Cui Y, Toyoda H, Sako T, Onoe K, Hayashinaka E, Wada Y, Yokoyama C, Onoe H, Kataoka Y, Watanabe Y.:
    "A voxel-based analysis of brain activity in high-order trigeminal pathway in the rat induced by cortical spreading depression."
    Neuroimage, 108: 17-22 (2015).
  • 9.Nakatomi Y, Mizuno K, Ishii A, Wada Y, Tanaka M, Tazawa S, Onoe K, Fukuda S, Kawabe J, Takahashi K, Kataoka Y, Shiomi S, Yamaguti K, Inaba M, Kuratsune H, Watanabe Y.:
    "Neuroinflammation in patients with chronic fatigue syndrome/myalgic encephalomyelitis: an 11C-(R)-PK11195 PET study."
    J Nucl Med, 108: 17-22 (2015).
  • 10.Yamato M, Kataoka Y.:
    "Fatigue sensation following peripheral viral infection is triggered by neuroinflammation: who will answer these questions?"
    Neural Regen Res, 10: 203-204 (2015).

Related Links

Lab Members

Principal investigator

Yosky Kataoka
Team Leader

Core members

Yasuhisa Tamura
Deputy Team Leader
Masanori Yamato
Research Scientist
Asami Eguchi
Technical Staff I
Kumi Takata
Technical Staff I
Sally Danno
Technical Staff I
Mayako Okamoto
Kunpei Kawakatsu
Junior Research Associate
Mitsuyo Maeda
Senior Visiting Scientist
Kazuo Funabiki
Senior Visiting Scientist
Toshiyuki Goto
Visiting Scientist
Nozomu Kubota
Visiting Scientist
Chie Ueta
Visiting Technician
Yuki Okinaka
Student Trainee
Tomoka Akita
Research Part-time Worker II
Yoshika Seta
Research Part-time Worker II
Shizuka Kozaki
Research Part-time Worker II

Contact Information

6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan
Email: kataokay [at] riken.jp