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RIKEN Center for Biosystems Dynamics Research Laboratory for Cell Signaling Dynamics

Team Leader: Masahiro Ueda (Ph.D.)

Research Summary

Masahiro  Ueda(Ph.D.)

Our group studies how signal transduction function of living cells arises spontaneously from the dynamics of intracellular reaction networks (design principles), and the mechanisms that allow these systems to process signals under the strong influence of thermal and stochastic noise (computation principles). As a typical example of stochastic biomolecular computation in living cells, we specifically focus on the gradient sensing and directional cell migration seen in the cellular slime mold Dictyostelium discoideum. In this research project, by combining advanced imaging techniques including single-molecule detection with theoretical modeling, we aim to better understand these two principles while at the same time develop the techniques necessary to do so.

Main Research Fields

  • Biology

Related Research Fields

  • Mathematical & Physical Sciences
  • Medicine, Dentistry & Pharmacy


  • Nanobiology
  • Cell signaling
  • Bioimaging
  • Mathematical modeling
  • Optical microscopy

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

  • 1.Kamimura, Y., Miyanaga, Y. & Ueda, M.
    "Heterotrimeric G protein shuttling via Gip1 extends the dynamic range of eukaryotic chemotaxis.",
    Proc. Natl. Acad. Sci. USA., 113: 4356-4361 (2016).
  • 2.Komatsuzaki, A., Ohyanagi, T., Tsukasaki, Y., Miyanaga, Y., Ueda, M. & Jin, T.:
    "Compact Halo-Ligand-Conjugated Quantum Dots for Multicolored Single-Molecule Imaging of Overcrowding GPCR Proteins on Cell Membranes"
    Small 11, 1396-1401 (2015)
  • 3.Yasui, M., Matsuoka, S. & Ueda, M.:
    "PTEN Hopping on the Cell Membrane Is Regulated via a Positively-Charged C2 Domain"
    PLoS Comput. Biol. 10 (2014)
  • 4.Cai, H., Katoh-Kurasawa, M., Muramoto, T., Santhanam, B., Long, Y., et al.:
    "Nucleocytoplasmic Shuttling of a GATA Transcription Factor Functions as a Development Timer"
    Science 343, 1329-+ (2014)
  • 5.Nishikawa, M., Horning, M., Ueda, M. & Shibata, T.:
    "Excitable Signal Transduction Induces Both Spontaneous and Directional Cell Asymmetries in the Phosphatidylinositol Lipid Signaling System for Eukaryotic Chemotaxis"
    Biophys. J. 106, 723-734 (2014)
  • 6.Okamoto, M., Namba, T., Shinoda, T., Kondo, T., Watanabe, T., et al.:
    "TAG-1-assisted progenitor elongation streamlines nuclear migration to optimize subapical crowding"
    Nat. Neurosci. 16, 1556-1566 (2013)
  • 7.Matsuoka, S., Shibata, T. & Ueda, M.:
    "Asymmetric PTEN Distribution Regulated by Spatial Heterogeneity in Membrane-Binding State Transitions"
    PLoS Comput. Biol. 9 (2013)
  • 8.Nishimura, S. I., Ueda, M. & Sasai, M.:
    "Non-Brownian dynamics and strategy of amoeboid cell locomotion"
    Phys. Rev. E 85 (2012)
  • 9.Tsujioka, M., Yumura, S., Inouye, K., Patel, H., Ueda, M. & Yonemura, S.:
    "Talin couples the actomyosin cortex to the plasma membrane during rear retraction and cytokinesis "
    Proc. Natl. Acad. Sci. U.S.A. 109, 12992-12997 (2012)
  • 10.*Arai, Y., Shibata, T., Matsuoka, S., Sato, M. J., Yanagida, T. & Ueda, M.:
    "Self-organization of the phosphatidylinositol lipids signaling system for random cell migration"
    Proc. Natl. Acad. Sci. U.S.A. 107, 12399-12404 (2010)

Recent Research Results

Related Links

Lab Members

Principal investigator

Masahiro Ueda
Team Leader

Core members

Michio Hiroshima
Senior Scientist
Yoichiro Kamimura
Senior Scientist
Satomi Matsuoka
Research Scientist
Jun Kozuka
Research Scientist
Masato Yasui
Postdoctoral Researcher
Hiroyasu Koteishi
Postdoctoral Researcher
Kazutoshi Takebayashi
Junior Research Associate
Daisuke Yoshioka
Junior Research Associate
Hidenori Hashimura
Junior Research Associate
Kaori Tanabe
Technical Staff I
Sizuka Taguchi
Technical Staff I
Akiko Kanayama
Technical Staff I

Contact Information

Email: masahiroueda [at] riken.jp