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RIKEN Center for Biosystems Dynamics Research Laboratory for Cell Systems Control

Team Leader: Yuichi Taniguchi (Ph.D.)

Research Summary

Yuichi  Taniguchi(Ph.D.)

We are a group of scientists pursuing systems-level biology of single cells. We aim to develop new innovative technologies for comprehensive and exhaustive quantification of single cells that are consists of vast kinds of machinery such as DNA, gene expression products and chemicals. In parallel, utilizing recent advanced technologies, we challenge to analyze dynamic and systematic properties of single cells in a process of a variety of biological phenomena such as cell differentiation. In the end, we aim to find a general concept to understand complex cellular systems from a molecular basis.

Main Research Fields

  • Biological Sciences

Related Research Fields

  • Interdisciplinary Science & Engineering

Keywords

  • Single cell analysis
  • Single molecule and super resolution microscopy
  • Genome structure
  • Central dogma
  • System wide analysis

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

  • 1.Leclerc, S., Arntz, Y., Taniguchi, Y.:
    "Proteome-wide quantification of labeling homogeneity at the single molecule level"
    J. Vis. Exp. 146, e59199 (2019).
  • 2.Yoshida, Y., Taniguchi, Y.:
    "Simultaneous single-cell measurements demonstrate a positive correlation between RNA copy number for
    mitochondrial division and fusion genes and mitochondrial fragmentation"
    Cytologia 84, 15-23 (2019)
  • 3.Ohno M, Ando T, Priest D.G., et.al.:
    "Sub-nucleosomal genome structure reveals distinct nucleosome folding motifs"
    Cell (2019) doi: 10.1016/j.cell.2018.12.014
  • 4.Leclerc S, Arntz Y, Taniguchi Y.:
    "Extending Single Molecule Imaging to Proteome Analysis by Quantitation of Fluorescent Labeling Homogeneity in Complex Protein Samples"
    Bioconjugate Chemistry (2018) doi: 10.1021/acs.bioconjchem.8b00226
  • 5.Ohno M, Priest DG, Taniguchi Y.:
    "Nucleosome-level 3D organization of the genome"
    Biochemical Society Transactions (2018) doi: 10.1042/BST20170388
  • 6.Priest D, Tanaka N, Tanaka Y, Taniguchi Y.:
    "Micro-patterned agarose gel devices for single-cell high-throughput microscopy of E. coli cells"
    Scientific Reports 7. 17750 (2017) doi: 10.1038/s41598-017-17544-2
  • 7.Taniguchi Y.:
    "Autofluorescence imaging of tissue samples using super-high sensitivity fluorescence microscopy"
    Global Imaging Insights 2. 1-2 (2017) doi: 10.15761/GII.1000135
  • 8.Taniguchi, Y.:
    "Genome-Wide Analysis of Protein and mRNA Copy Numbers in Single Escherichia coli Cells with Single-Molecule Sensitivity"
    Methods Mol. Biol. 1346, 55-67 (2015)
  • 9.Ohno, M., Karagiannis, P. & Taniguchi, Y.:
    "Protein Expression Analyses at the Single Cell Level"
    Molecules 19, 13932-13947 (2014)
  • 10.*Taniguchi, Y., Choi, P. J., Li, G., Chen, H., Babu, M., et al.:
    "Quantifying E-coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells"
    Science 329, 533-538 (2010)

Recent Research Results

Related Links

Lab Members

Principal investigator

Yuichi Taniguchi
Team Leader

Core members

Masae Johmura
Research Scientist
Soo Yeon Kim
Special Postdoctoral Researcher
Vipin Kumar
Research Associate
Yoshiki Okita
Junior Research Associate
Binti Kamarulzaman Latiefa
Student Trainee
Mayumi Ishida
Technical Staff I
Shouko Ohara
Administrative Part-time Worker II
Yue Wang
Research Part-time Worker II
Yuriko Okuda
Assistant

Contact Information

6-2-3, Furuedai
Suita, Osaka
565-0874 JAPAN
Email: taniguchi [at] riken.jp

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