RIKEN Center for Biosystems Dynamics Research Laboratory for Integrated Biodevice

Team Leader: Eisuke Nishida (Ph.D.)

Japanese Page

Research Summary

This laboratory aims to promote integration and sophistication of biological experiments using micro structures and channels based on semiconductor fabrication methods. These sizes are near the size of hair or mosquito needle width （10~100 μm） or less. By exploiting these devices to chemical or biological fields, precise cell or molecular handling can be realized. Furthermore, our group focuses on unique functions of cells or tissue of living creatures. By combining this with microfabrication technology, we aim to new functional devices and propose future ideal machine models.

Main Research Fields

Engineering

Related Research Fields

Chemistry

Keywords

Micro/nano fluidics
Analytical chemistry
Device engineering
Micro/nano fabrication
Cell function utilization

Selected Publications

1.Yalikun, Y. and Tanaka, Y.:
"Ultra-thin glass sheet integrated transparent diaphragm pressure transducer"
Sens. Actuators A-Phys. 263, 102-112 (2017)
2.Tanaka, N., Yamashita T., Sato A., Vogel V. and Tanaka, Y..:
"Simple agarose micro-confinement array and machine-learning-based classification for analyzing the patterned differentiation of mesenchymal stem cells"
PLoS ONE, 12, e0173647 (2017)
3.Tanaka, Y., Noguchi, Y., Yalikun, Y. and Kamamichi, N.:
"Earthworm muscle driven bio-micropump"
Sens. Actuators B-Chem. 242, 1186-1192 (2017)
4.Funano, S., Tanaka, N. and Tanaka, Y.:
"Vapor-based micro/nano-partitioning of fluorofunctional group immobilization for long-term stable cell patterning"
RSC Adv. 6, 96306-96313 (2016)
5.Tanaka, Y., Funano, S., Nishizawa, Y., Kamamichi, N., Nishinaka, M. and Kitamori, T.:
"An electric generator using living Torpedo electric organs controlled by fluid pressure-based alternative nervous systems"
Sci. Rep. 6, 25899 (2016)
6.Tanaka, N., Moriguchi H., Sato A., Kawai T., Shimba K., Jimbo Y. and Tanaka Y.:
"Microcasting with agarose gel via degassed polydimethylsiloxane molds for repellency-guided cell patterning"
RSC Adv. 6, 54754-54762 (2016)
7.Yalikun, Y., Hosokawa, Y., Iino, T. and Tanaka Y.:
"All-glass 12-μm ultra-thin and flexible micro-fluidic chip fabricated by femtosecond laser processing"
Lab Chip 16, 2427-2433 (2016)
8.Moriguchi, H., Kawai, T. and Tanaka, Y.:
"Simple bilayer on-chip valves using reversible sealability of PDMS"
RSC Adv. 5, 5237-5243 (2015)
9.Tanaka, Y. and Fujita, H.:
"Fluid driving system for a micropump by differentiating iPS cells into cardiomyocytes on a tent-like structure"
Sens. Actuators B-Chem. 210, 267-272 (2015)
10.Tanaka, Y.:
"Electric actuating valves incorporated into an all glass-based microchip exploiting the flexibility of ultra thin glass"
RSC Adv. 3, 10213-10220 (2013)