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RIKEN Center for Biosystems Dynamics Research Laboratory for Molecular Biology of Aging

Team Leader: Eisuke Nishida (Ph.D.)

Research Summary

Eisuke  Nishida(Ph.D.)

The organismal lifespan varies from species to species, and it also varies among individuals of the same species. Despite such large differences in the organismal lifespan or the rate of aging, recent studies suggest the existence of the common mechanisms of lifespan/aging regulation. The best studied common mechanism of lifespan regulation came from the research using a tiny soil worm called C. elegans. Both “nature (genetic factors)” and “nurture (environmental factors)” are shown to influence lifespan/aging. Our laboratory uses C. elegans and small fish to understand the molecular mechanisms underlying lifespan regulation by genetic and environmental factors.

Main Research Fields

  • Biology

Related Research Fields

  • Biological Sciences
  • Medicine, Dentistry & Pharmacy


  • Inter-organ communications underlying aging regulation
  • Epigenomic regulation of aging
  • Mechanisms of transgenerational inheritance of epigenetic memories

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

  • 1.*Ikeda, T., Uno, M., Honjoh, S. & Nishida, E.:
    "The MYST family histone acetyltransferase complex regulates stress resistance and longevity through transcriptional control of DAF-16/FOXO transcription factors."
    EMBO Reports 18(10), 1716-1726 (2017)doi:10.15252/embr.201743907
  • 2.*Kishimoto, S., Uno, M., Okabe, E. et al.:
    "Environmental stresses induce transgenerationally inheritable survival advantages via germline-to-soma communication in Caenorhabditis elegans."
    Nature Communications 8, 14031. (2017) doi:10.1038/ncomms14031
  • 3.*Miyatake, K., Kusakabe, M., Takahashi, C. & Nishida E.:
    "ERK7 regulates ciliogenesis by phosphorylating the actin regulator CapZIP in cooperation with Dishevelled."
    Nature Communications 6, 6666 (2015) doi:10.1038/ncomms7666
  • 4.*Takahashi, C., Kusakabe, M., Suzuki, T. et al.:
    "mab21-l3 regulates cell fate specification of multiciliate cells and ionocytes."
    Nature Communications 6, 6017 (2015) doi:10.1038/ncomms7017
  • 5.*Imajo, M., Ebisuya, M. & Nishida E.:
    "Dual role of YAP and TAZ in renewal of the intestinal epithelium."
    Nature Cell Biology 17(1), 7-19 (2015) doi:10.1038/ncb3084
  • 6.*Sunadome, K., Suzuki, T., Usui, M. et al.:
    "Antagonism between the Master "Regulators of Differentiation Ensures the Discreteness and Robustness of Cell Fates."
    Molecular Cell 54(3), 526-535 (2014) doi:10.1016/j.molcel.2014.03.005
  • 7.*Uno, M., Honjoh, S., Matsuda, M. et al.:
    "A fasting-responsive signaling pathway that extends life span in C. elegans."
    Cell Reports 3(1),79-91 (2013) doi:10.1016/j.celrep.2012.12.018
  • 8.*Okuyama, T., Inoue, H., Ookuma, S. et al.:
    "The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans."
    Journal of Biological Chemistry 285(39), 30274-30281 (2010) doi:10.1074/jbc.M110.146274
  • 9.*Hanafusa, H., Matsumoto, K. & Nishida, E.:
    "Regulation of ERK activity duration by Sprouty contributes to dorsoventral patterning."
    Nature Cell Biology 11, 106-109 (2009) doi:10.1038/ncb1820
  • 10.Honjoh, S., Yamamoto, T., Uno, M. & Nishida, E.:
    "Signaling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans."
    Nature 457, 726-730 (2009) doi:10.1038/nature07583

Recent Research Results

Related Links

Lab Members

Principal investigator

Eisuke Nishida
Team Leader

Core members

Masaharu Uno
Research Scientist
Chika Takahashi
Research Scientist
Emiko Okabe
Research Scientist
Masanori Nono
Research Scientist

Contact Information

Developmental Biology Building
2-2-3 Minatojima-minamimachi, Chuo-ku
Kobe, Hyogo
650-0047 Japan
Email: eisuke.nishida [at] riken.jp