1. Home
  2. Research
  3. Centers & Labs
  4. RIKEN Center for Biosystems Dynamics Research

RIKEN Center for Biosystems Dynamics Research Laboratory for Molecular Delivery and Imaging Technology

Team Leader: Hidefumi Mukai (Ph.D.)

Research Summary

Hidefumi  Mukai(Ph.D.)

The objective of our team is to develop evaluation and verification technologies of the function of control molecules in situ and in vivo, and to develop an efficient Drug Delivery System (DDS).

Main Research Fields

  • Medicine, Dentistry & Pharmacy

Related Research Fields

  • Biological Sciences


  • Drug Delivery system (DDS)
  • Positron Emission Tomography (PET)
  • Therapeutic Bacteria Machine

Selected Publications

  • 1. Nomura S, Takahashi M, Hashiba Kato A, et al.:
    "Biosorption-based 64Cu-labeling of bacteria for pharmacokinetic positron-emission tomography"
    International Journal of Pharmaceutics 590. 119950 (2020) doi:10.1016/j.ijpharm.2020.119950
  • 2. Mukai H, Watanabe Y.:
    "Review: PET imaging with macro- and middle-sized molecular probes."
    Nuclear Medicine and Biology, in press, doi:10.1016/j.nucmedbio.2020.06.007
  • 3. Sakai K, Passioura T, Sato H, et al.:
    "Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor."
    Nature Chemical Biology 15. 598–606 (2019) doi: 10.1038/s41589-019-0285-7
  • 4. Ren Q, Mohri K, Warashina S, et al.:
    "Improved immuno-PET imaging of HER2-positive tumors in mice: Urokinase injection-triggered clearance enhancement of 64Cu-trastuzumab."
    Molecular Pharmaceutics 16(3). 1065-1073 (2019) doi:10.1021/acs.molpharmaceut.8b01052
  • 5. Mukai H, Hatanaka K, Yagi N, et al.:
    "Pharmacokinetic evaluation of liposomal nanoparticle-encapsulated nucleic acid drug: A combined study of dynamic PET imaging and LC/MS/MS analysis."
    Journal of Controlled Release 294. 185-194 (2019) doi: 10.1016/j.jconrel.2018.12.006
  • 6. Nakamoto Y, Pradipta AR, Mukai H, et al.:
    "Expanding the applicability of the metal labeling of biomolecules by the RIKEN click reaction: A case study with Gallium‐68 positron emission tomography."
    Chembiochem 19. 2055-2060 (2018) doi: 10.1002/cbic.201800335
  • 7. Matsumura K, Zouda M, Wada Y, et al.:
    "Urokinase injection-triggered clearance enhancement of a 4-arm PEG-conjugated 64Cu-bombesin analog tetramer: A novel approach for the improvement of PET imaging contrast."
    International Journal of Pharmaceutics 545. 206-214 (2018) doi:10.1016/j.ijpharm.2018.05.014
  • 8. Mukai H, Takahashi M, Watanabe Y.:
    "Potential usefulness of Brevibacillus for bacterial cancer therapy: intratumoral provision of tumor necrosis factor- α and anticancer effects."
    Cancer Gene Therapy 25. 47-57 (2018) doi:10.1038/s41417-017-0009-7
  • 9. Otani Y, Kawakami S, Mukai H, et al.:
    "Long-term in vivo gene expression in mouse kidney using φ31 integrase and electroporation."
    Journal of Drug Targeting 23. 427-435 (2015) doi:10.3109/1061186X.2014.1002788
  • 10. Mukai H, Ozaki D, Cui YL, et al.:
    "Quantitative evaluation of the improvement in the pharmacokinetics of a nucleic acid drug delivery system by dynamic PET imaging with 18 F-incorporated oligodeoxynucleotides."
    Journal of Controlled Release 180. 92-99 (2014) doi:10.1016/j.jconrel.2014.02.014

Related Links

Lab Members

Principal investigator

Hidefumi Mukai
Team Leader

Core members

Kota Mori
Research Scientist
Shota Warashina
Research Scientist
Shoko Nomura
Postdoctoral Researcher
Maiko Takahashi
Research Associate
Naomi Fujie
Temporary Staffing
Yoko Nagatomo

Contact Information

6-7-3 Minatojima-minamimachi, Chuo-ku
Kobe, Hyogo
650-0047 Japan
Tel: +81-(0)78-304-7173
Email: hmukai [at] riken.jp