Research Summary

Selected Publications

• 1.Sakamoto, K. and Hayashi, A.:
  "Synthetic tyrosine tRNA molecules with noncanonical secondary structures"
  Int. J. Mol. Sci. 20(1), 92 (2019)
• 2.Teramoto, H., Amano, Y., Iraha, F., Kojima, K., Ito, T., and Sakamoto, K.:
  "Genetic code expansion of the silkworm Bombyx mori to functionalize silk fiber"
  ACS Synth. Biol. 7, 801-806 (2018)
• 3.Ohtake, K., and Mukai, T., Iraha, F., Takahashi, M., Haruna, K., Date, M., Yokoyama, K., and Sakamoto, K.:
  "Engineering an automaturing transglutaminase with enhanced thermostability by genetic code expansion with two codon reassignments"
  ACS Synth. Biol. 7, 2170-2176 (2018)
• 4.Handoko, L., Kaczkowski, B., Hon C.-C., Lizio, M., Wakamori, M., Matsuda T., Ito T., Jeyamohan P., Sato, Y., Sakamoto, K., Yokoyama, S., Kimura, H., Minoda, A., and Umehara T.:
  "JQ1 affects BRD2-dependent and independent transcription regulation without disrupting H4-hyperacetylated chromatin states"
  Epigenetics 13, 410-431 (2018)
• 5.Takahashi, M., and Sakamoto, K.:
  "Engineering of Escherichia coli Β-lactamase TEM-1 variants showing higher activity under acidic conditions than at the neutral pH"
  Biochem. Biophys. Res. Commun. 505, 333-337 (2018)
• 6.Yamaguchi, A., Iraha, F., Ohtake, K., and Sakamoto, K.:
  "Pyrrolysyl-tRNA synthetase with a unique architecture enhances the availability of lysine derivatives in synthetic genetic codes"
  Molecules 23, 2460 (2018)
• 7.Osamura, T., and OkudaM., Yamaguchi, A., Ohtake, K., Sakamoto, K., and Takimura, Y.:
  "Variants of the industrially relevant protease KP-43 with suppressed activity under alkaline conditions developed using expanded genetic codes"
  Biochem. Biophys. Rep., 17, 93-96 (2018)
• 8.Yamaguchi, A., Matsuda, T., Ohtake, K., Yanagisawa, T., Yokoyama, S., Fujiwara, Y., Watanabe, T., Hohsaka, T., and Sakamoto, K.:
  "Incorporation of a doubly functionalized synthetic amino acid into proteins for creating chemical and light-induced conjugates"v
  Bioconjug Chem. 27, 198-206 (2015)
• 9.Mukai, T., Yamaguchi, A., Ohtake, K., Takahashi, M., Hayashi, A., Iraha, F., Kira, S., Yanagisawa, T., Yokoyama, S., Hoshi, H., Kobayashi, T. and Sakamoto, K.:
  "Reassignment of a rare sense codon to a non-canonical amino acid in Escherichia coli"
  Nucleic. Acids Res. 43, 8111-8122 (2015)
• 10.Mukai, T., Hoshi, H., Ohtake, K., Takahashi, M., Yamaguchi, A., Hayashi, A., Yokoyama, S., and Sakamoto, K.:
  "Highly reproductive Escherichia coli cells with no specific assignment to the UAG codon"
  Sci Rep. 5: 9699 (2015)

Recent Research Results

• 

  May 9, 2022
  Iron-snatching compound effective against the parasitic amoeba Entamoeba histolytica

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