Research Summary

Research Subjects

• Molecular imaging study on newly developed biomarkers for evaluation of health and pre-disease state
• Molecular imaging study on newly developed biomarkers for evaluation of disease state
• Development of molecular imaging indices for products to avoid deterioration of health

Selected Publications

• 1.Mizuno, K., Tanaka, M., Tanabe, H.C., Joudoi, T., Kawatani, J., Shigihara, Y., Tomoda, A., Miike, T., Imai-Matsumura, K., Sadato, N., and Watanabe, Y.:
  "Less efficient and costly processes of frontal cortex in childhood chronic fatigue syndrome."
  Neuroimage Clin., 9: 355-368, 2015.
• 2.Niwa, T., Ochiai, H., Watanabe, Y., and Hosoya, T.:
  "Ni/Cu-Catalyzed Defluoroborylation of Fluoroarenes for Diverse C-F Bond Functionalizations."
  J. Am. Chem. Soc., 137(45): 14313-14318, 2015.
• 3.Doi, H., Mawatari, A., Kanazawa, M., Nozaki, S., Nomura, Y., Kitayoshi, T., Akimoto, K., Suzuki, M., Ninomiya, S., and Watanabe, Y.:
  "Synthesis of 11C-labeled thiamine and fursultiamine for in vivo molecular imaging of vitamin B1 and its prodrug using positron emission tomography."
  J. Org. Chem., 80(12): 6250-6258, 2015.
• 4.Cui, YL., Toyoda, H., Sako, T., Onoe, K., Hayashinaka, E., Wada, Y., Yokoyama, C., Onoe, H., Kataoka, Y., and Watanabe, Y.:
  "A voxel-based analysis of brain activity in high-order trigeminal pathway in the rat induced by cortical spreading depression."
  NeuroImage, 108:17-22, 2015.
• 5.Takahashi, K., Hosoya, T., Onoe, K., Doi, H., Nagata, H., Hiramatsu, T., Li, X-L., Watanabe, Yu., Wada, Y., Takashima, T., Suzuki, M., Onoe, H., and Watanabe, Y.:
  "[¹¹C]Cetrozole: an improved C-[¹¹C]methylated PET probe for aromatase imaging in the brain."
  J. Nucl. Med., 55(5): 852-857, 2014.
• 6.Nomura, S., Nozaki, S., Hamazaki, T., Takeda, T., Ninomiya, E., Kudo, S., Hayashinaka, E., Wada, Y., Hiroki, T., Fujisawa, C., Kodama, H., Shintaku, H., and Watanabe, Y.:
  "PET Imaging analysis with⁶⁴Cu in disulfiram treatment for aberrant copper bio-distribution in menkes disease mouse model."
  J. Nucl. Med., 55(5): 845-851, 2014.
• 7.Mukai, H., Ozaki, D., Cui, Y.L., Kuboyama, T., Yamato-Nagata, H., Onoe, K., Takahashi, M., Wada, Y., Imanishi, T., Kodama, T., Obika, S., Suzuki, M., Doi, H., and Watanabe, Y.:
  "Quantitative evaluation of the improvement in the pharmacokinetics of a nucleic acid drug delivery system by dynamic PET imaging with¹⁸F-incorporated oligodeoxynucleotides."
  J. Control. Release, 180: 92-99, 2014.
• 8.Nakatomi, Y., Mizuno, K., Ishii, A., Wada, Y., Tanaka, M., Tazawa, S., Onoe, K., Fukuda, S., Kawabe, J., Takahashi, K., Kataoka, Y., Shiomi, S., Yamaguti, K., Inaba, M., Kuratsune, H., and Watanabe, Y.:
  "Neuroinflammation in patients with chronic fatigue syndrome/myalgic encephalomyelitis: a¹¹C-(R)-PK11195 positron emission tomography study."
  J. Nucl. Med., 55(6):945-950, 2014.
• 9.Tamura, K., Kurihara, H., Yonemori, K., Tsuda, H., Suzuki, J., Kono, Y., Honda, N., Kodaira, M., Yamamoto, H., Yunokawa, M., Shimizu, C., Hasegawa, K., Kanayama, Y., Nozaki, S., Kinoshita, T., Wada, Y., Tazawa, S., Takahashi, K., Watanabe, Y., and Fujiwara, Y.:
  "⁶⁴Cu-DOTA-Trastuzumab PET imaging in patients with HER2-Positive breast cancer."
  J. Nucl. Med., 54(11): 1869-1875, 2013.
• 10.Mizuno, K., Yoneda, T., Komi, M., Hirai, T., Watanabe, Y., and Tomoda, A.:
  "Osmotic release oral system-methylphenidate improves neural activity during low reward processing in children and adolescents with attention-deficit/hyperactivity disorder."
  NeuroImage Clin., 2: 366-376, 2013.

Recent Research Results

• 

  Jul. 12, 2019
  Using the RIKEN click reaction to weaponize antibodies against cancer

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