Research Summary

Research Subjects

• Technology development for comprehensive analysis of epigenome of small number of cells.
• Studies on genomic reprogramming and cell differentiation during mammalian development
• Technology development for visualization and imaging analyses of biological phenomena

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

• 1.*Sugimoto, M., Kondo, M., Koga, Y., Shiura, H., Ikeda, R., Hirose, M., Ogura, A., Murakami, A., Yoshiki, A., Chuva de Sousa Lopes, S., Abe, K.:
  “A simple and robust method for establishing homogeneous mouse epiblast stem cell lines by Wnt inhibition.”
  Stem Cell Reports in press. (2015).
• 2.Shiura, H., Okamoto, A. Sasaki, H. and Abe, K.:
  “A novel technique for simultaneous visualization of specific DNA methylation and protein/RNA expression.”
  PLoS One. 9, e95750(2014)
• 3.Ikeda, R., Shiura, H., Numata, K., Sugimoto, M., Kondo, M., Mise, N., Suzuki, M., Greally, J.M. and Abe, K.:
  “Large, male germ cell-specific hypomethylated DNA domains with unique genomic and epigenomic features on the mouse X chromosome.”
  DNA Research 20, 549-565. (2013)
• 4.*Maeda, I., Okamura, D., Tokitake, Y., Ikeda, M., Kawaguchi, H., Mise, N., Abe, K., Noce, T., Okuda, A. and Matsui, Y.:
  “Max is a repressor of germ-cell-related gene expression in mouse embryonic stem cells.”
  Nature communications 4, 1754. (2013)
• 5.Shiura, H., Ikeda, R., Lee, J., Sato, T., Ogonuki, N., Hirose, M., Ogura, A., Ogawa, T., Abe, K.: “Generation of a novel germline stem cell line expressing a germline-specific reporter in the mouse.”
  genesis 51, 498-505. (2013).
• 6.*Semba, K., Araki, K., Matsumoto, K.-I., Suda, H., Ando, T. Sei, A., Mizuta, H., Takagi, K., Nakahara, M., Muta, M., Yamada, G., Nakagata, N., Iida, A., Ikegawa, Y., Araki, M., Abe, K. and Yamamura, K.:
  “The ectopic expression of Ptf1a induces spinal defects, urogenital defects and anorectal malformations in Danforth's short tail mice.”
  PLoS Genet. 9, e1003204. (2012)
• 7.Sugimoto, M., Kondo, M., Hirose, M., Suzuki, M., Mekada, K., Abe, T., Kiyonari, H., Ogura, A., Takagi, N., Artzt, K. and Abe, K.:
  “Molecular identification of t^w5: Vps52 promotes pluripotential cell differentiation through cell-cell interactions.”
  Cell Reports 2, 1363-1374. (2012).
• 8.*Okamura, D., Maeda, I., Taniguchi, H., Tokitake, Y., Ikeda, M., Ozato, K., Mise, N., Abe, K., Noce, T., Belmonte, J.C.I., Matsui, Y.:
  “Cell-cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells.”
  Genes Dev. 26, 2477-2482. (2012).
• 9.Cao, L, Kobayakawa, S., Yoshiki, A., Abe, K.:
  “High resolution intravital imaging of subcellular structures of mouse abdominal organs using a microstage device.”
  PLoS One e33876. (2012)
• 10.Kasahara, T., Abe, K., Mekada, K., Yoshiki, A., Kato, T.:
  “Genetic variation of melatonin productivity in laboratory mice under domestication.”
  Proc. Natl. Acad. Sci, USA 107, 6412-6417. (2010)

Recent Research Results

• Aug. 23, 2013
  Honing in on developmental epigenetics

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