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RIKEN Baton Zone Program Nano-crystallography unit

Unit Leader: Yusuke Nishiyama (Ph.D.)

Research Summary

Yusuke  Nishiyama(Ph.D.)

We are focusing on new methodology development to solve the crystalline structure of nano- to micro-meter sized particles using electron and NMR nanocrystallography approach. The approach combining the electron diffraction and solid-state NMR and gives deeper insights into molecular structure including hydrogen positions. We are also working on application of the methods to wide varieties of materials including pharmaceutical materials, biomolecules, proteins, organic-inorganic hybrid materials etc.

Main Research Fields

  • Chemistry

Related Research Fields

  • Interdisciplinary Science & Engineering


  • solid-state NMR
  • electron diffraction
  • nano-crystallography

Selected Publications

  • 1. Nghia Tuan Duong*, Yusuke Nishiyama*.
    "Detection of remote proton-nitrogen correlations by 1H-detected 14N overtone solid-state NMR at fast MAS"
    Phys. Chem. Chem. Phys. in press. DOI: 10.1039/D2CP00155A
  • 2. Nghia Tuan Duong, Vipin Agarwal, Yusuke Nishiyama*.
    "Separating an overlapped 1H peak and identifying its 1H-1H correlations with the use of single-channel 1H solid-state NMR at fast MAS"
    Solid State Nucl. Magn. Reson. 117 (2022) 101774. DOI: 10.1016/j.ssnmr.2022.101774
  • 3. Ekta Nehra, Neelam Sehrawat, Takeshi Kobayashi, Yusuke Nishiyama*, Manoj Kumar Pandey*.
    "Proton-detected 15N-1H dipolar coupling/1H chemical shift correlation experiment for the measurement of NH distances in biological solids under fast MAS solid-state NMR"
    J. Magn. Reson. Open, 10-11 (2022) 100028. DOI: 10.1016/j.jmro.2021.100028
  • 4. Ziya Liu, Kun Zhang, Guoji Huang, Bingqing Xu*, You-lee Hong, Xiaowei Wu, Yusuke Nishiyama, Satoshi Horike*, Gen Zhang* and Susumu Kitagawa.
    "High-Processable COF Gel Electrolyte Enabled by Side Chain Engineering for Lithium-ion Battery"
    Angew. Chem. Int. Ed. 61 (2022) e202110695. DOI: 10.1002/ange.202110695
  • 5. Alons Lends*, Mélanie Berbon, Birgit Habenstein, Yusuke Nishiyama*, and Antoine Loquet*.
    "Protein resonance assignment by solid-state NMR based on 1H-detected 13C double-quantum spectroscopy at fast MAS"
    J. Biomol. NMR 75 (2021) 417-427. DOI: 10.1007/s10858-021-00386-6
  • 6. Kentaro Kadota, You-lee Hong, Yusuke Nishiyama, Easan Sivaniah, Daniel Packwood, and Satoshi Horike*.
    "One-Pot, Room-Temperature Conversion of CO2 into Porous Metal–Organic Frameworks"
    J. Am. Chem. Soc. (2021) J. Am. Chem. Soc. 143 (2021) 16750-16757. DOI: 10.1021/jacs.1c08227
  • 7. Rognchun Zhang*, Vipin Agarwal*, Yusuke Nishiyama*.
    "Proton Triple-Quantum Solid-State NMR spectroscopy at slow MAS ~10 kHz"
    J. Magn. Reson. Open 8-9 (2021) 100020. DOI: 10.1016/j.jmro.2021.100020
  • 8. Zhen Shan, Miaomiao Wu, Zhangjie Gu, Yusuke Nishiyama, Gen Zhang*.
    "A Nonplanar 2D Covalent Organic Framework Derived from a Z-shaped Building Unit,"
    Chem. Comm. 57 (2021) 9236-9239. DOI: 10.1039/D1CC04103G
  • 9. Nghia Tuan Duong, Yoshitaka Aoyama, Katsumi Kawamoto, Toshio Yamazaki, Yusuke Nishiyama*.
    "Structure Solution of Nano-Crystalline Small Molecules Using MicroED and Solid-State NMR Dipolar-Based Experiments"
    Molecules 26 (2021) 4652. DOI: 10.3390/molecules26154652
  • 10. Xiaowei Wu, Ziya Liu, Hu Guo, You-lee Hong, Bingqing Xu*, Kun Zhang, Yusuke Nishiyama, Wei Jiang, Satoshi Horike, Susumu Kitagawa, Gen Zhang*.
    "Host–Guest Assembly of H-Bonding Networks in Covalent Organic Frameworks for Ultrafast and Anhydrous Proton Transfer"
    ACS Appl. Mater. Interfaces, 13 (2021) 37172-37178. DOI: 10.1021/acsami.1c09157

Lab Members

Principal investigator

Yusuke Nishiyama
Unit Leader

Contact Information

1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Email: yusuke.nishiyama [at] riken.jp