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RIKEN Baton Zone Program Multi-Modal Microstructure Analysis Unit

Unit Leader: Yosky Kataoka (M.D., Ph.D.)

Research Summary

Yosky  Kataoka(M.D., Ph.D.)
We are studying functional linkages among organs, tissues, and cells using multi-modal imaging technologies including PET, fluorescence/bioluminescence imaging, microendoscope imaging. In this research unit, particularly, we are challenging to extend such multi-modal imaging technologies to electron microscopic level, to observe the common cells and molecules in organ-, tissue-, cellular-, and subcellular levels. Further, we are developing a technology to obtain large-scale (> 1mm2) electron microscopic images of tissue microstructure and to analyze automatically such imaging big data.

Main Research Fields

  • Medicine, Dentistry & Pharmacy

Related Research Fields

  • Biological Sciences


  • Imaging
  • Large-scale electron microscopy
  • Omics
  • Aging
  • Stem cell

Selected Publications

  • 1.Koike, T., Tanaka, S., Hirahara, Y., Oe, S., Kurokawa, K., Maeda, M., Suga, M., Kataoka, Y., Yamada, H.:
    "Morphological characteristics of p75 neurotrophin receptor-positive cells define a new type of glial cell in the rat dorsal root ganglia"
    J. Comp. Neurol., in press
  • 2.Tamura, Y., Takata, K., Eguchi, A., and Kataoka, Y.:
    "In vivo monitoring of hair cycle stages via bioluminescence imaging of hair follicle NG2 cells"
    Scientific Reports 8, 393 (2018).
  • 3.Koike, T., Kataoka, Y., Maeda, M., Hasebe, Y., Yamaguchi, Y., Suga, M., Saito, A., and Yamada, H.:
    "A device for ribbon collection for array tomography with scanning electron microscopy"
    Acta Histochemica et Cytochemica 50 (5), 135-140 (2017).
  • 4.Kume, S., Masuya, H., Maeda, M., Suga, M., Kataoka, Y., Kobayashi, N.:
    "Development of Semantic Web-based imaging database for biological morphome"
    Semantic Technology 277-285 (2017).
  • 5.Nakano, M., Tamura, Y., Yamato, M., Kume, S., Eguchi, A., Takata, K., Watanabe, Y., and Kataoka, Y.:
    "NG2 glial cells regulate neuroimmunological responses to maintain neuronal function and survival"
    Scientific Reports 7, 42041 (2017).
  • 6.Yamano, E., Sugimoto, M., Hirayama, A., Kume, S., Yamato, M., Jin, G., Tajima, S., Goda, N., Iwai, K., Fukuda, S., Yamaguti, K., Kuratsune, H., Soga, T., Watanabe, Y., and Kataoka, Y.:
    "Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles"
    Scientific Reports 6, 34990 (2016).
  • 7.Tamura, Y., Takahashi, K., Takata, K., Eguchi, A., Yamato, M., Kume, S., Nakano, M., Watanabe, Y., and Kataoka, Y.:
    "Noninvasive Evaluation of Cellular Proliferative Activity in Brain Neurogenic Regions in Rats under Depression and Treatment by Enhanced [18F] FLT-PET Imaging"
    Journal of Neuroscience 36(31), 8123-8131 (2016).
  • 8.Iwawaki, T., Akai, R., Oikawa, D., Toyoshima, T., Yoshino, M., Suzuki, M., Takeda, N., Ishikawa, T., Kataoka, Y., and Yamamura, K.:
    "Transgenic mouse model for imaging of interleukin-1β-related inflammation in vivo"
    Scientific Reports 5, 17205 (2015).
  • 9.Kume, S., Yamato, M., Tamura, Y., Jin, G., Nakano, M., Miyashige, Y., Eguchi, A., Ogata, Y., Goda, N., Iwai, K., Yamano, E., Watanabe, Y., Soga, T., and Kataoka, Y.:
    "Potential biomarkers of fatigue identified by plasma metabolome analysis in rats"
    PLOS ONE 10(3), e0120106 (2015).
  • 10.Miyamoto, N., Maki, T., Shindo, A., Liang, A. C., Maeda, M., Egawa, N., Itoh, K., Lo, E. K., Lok, J., Ihara, M., and Arai1 K.:
    "Astrocytes promote oligodendrogenesis after white matter damage via brain-derived neurotrophic factor"
    Journal of Neuroscience 35, 14002-14008 (2015).

Lab Members

Principal investigator

Yosky Kataoka
Unit Leader

Core members

Yasuhisa Tamura
Senior Scientist
Norio Kobayashi
Senior Scientist
Masanori Yamato
Research Scientist
Satoshi Kume
Research Scientist
Asami Eguchi
Technical Staff I
Mitsuyo Maeda
Senior Visiting Scientist

Contact Information

MI R&D Building
6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047
Tel: +81-(0)78-304-7160
Fax: +81-(0)78-304-7161
Email: mayako.okamoto [at] riken.jp