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RIKEN Baton Zone Program Multi-Modal Microstructure Analysis Unit

Unit Leader: Yosky Kataoka (M.D., Ph.D.)

Research Summary

Yosky  Kataoka(M.D., Ph.D.)
We are studying functional linkages among organs, tissues, and cells using multi-modal imaging technologies including PET, fluorescence/bioluminescence imaging, microendoscope imaging. In this research unit, particularly, we are challenging to extend such multi-modal imaging technologies to electron microscopic level, to observe the common cells and molecules in organ-, tissue-, cellular-, and subcellular levels. Further, we are developing a technology to obtain large-scale (> 1mm2) electron microscopic images of tissue microstructure and to analyze automatically such imaging big data.

Main Research Fields

  • Medicine, Dentistry & Pharmacy

Related Research Fields

  • Biological Sciences

Keywords

  • Imaging
  • Large-scale electron microscopy
  • Omics
  • Aging
  • Stem cell

Selected Publications

  • 1. Konishi, H., Okamoto, T., Hara, Y., Komine, O., Tamada, H., Maeda, M., Osako, F., Kobayashi, M., Nishiyama, A., Kataoka, Y., Takai, T., Udagawa, N, Jung, S., Ozato, K., Tamura, T., Tsuda, M, Yamanaka, K., Ogi, T., Sato, K., Kiyama, H.:
    "Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction"
    EMBO Journal, in press
  • 2. Kikuchi-Taura, A., Okinaka, Y., Takeuchi, Y., Ogawa , Y., Maeda , M., Kataoka, Y., Yasui, T., Kimura, T., Gul, S., Claussen, C., Boltze, J., Taguchi, A.:
    "Bone marrow mononuclear cells activate angiogenesis via gap junction mediated cell-cell interaction"
    Stroke 51(4), 1279-1289 (2020).
  • 3. Maeda, M., Seto, T., Kadono, C., Morimoto, H., Kida, S., Suga, M., Nakamura, M., Kataoka, Y., Hamazaki, T., Shintaku, H.:
    "Autophagy in the Central Nervous System and Effects of Chloroquine in Mucopolysaccharidosis Type II Mice"
    International Journal of Molecular Sciences 20 (23), 5829 (2019).
  • 4. Ohtsuka, J., Fukumura, M., Furuyama, W., Wang, S., Hara, K., Maeda, M., Tsurudome, M., Miyamoto, H., Kaito, A., Tsuda, N., Kataoka, Y., Mizoguchi, A., Takada, A., Nosaka, T.:
    "A versatile platform technology for recombinant vaccines using non-propagative human parainfluenza virus type 2 vector"
    Scientific Reports 9, 12901 (2019).
  • 5. Tamura, Y., Takata, K., Eguchi, A., and Kataoka, Y.:
    "In vivo monitoring of hair cycle stages via bioluminescence imaging of hair follicle NG2 cells"
    Scientific Reports 8, 393 (2018).
  • 6. Kume, S., Masuya, H., Maeda, M., Suga, M., Kataoka, Y., Kobayashi, N.:
    "Development of Semantic Web-based imaging database for biological morphome"
    Semantic Technology 277-285 (2017).
  • 7. Nakano, M., Tamura, Y., Yamato, M., Kume, S., Eguchi, A., Takata, K., Watanabe, Y., and Kataoka, Y.:
    "NG2 glial cells regulate neuroimmunological responses to maintain neuronal function and survival"
    Scientific Reports 7, 42041 (2017).
  • 8. Yamano, E., Sugimoto, M., Hirayama, A., Kume, S., Yamato, M., Jin, G., Tajima, S., Goda, N., Iwai, K., Fukuda, S., Yamaguti, K., Kuratsune, H., Soga, T., Watanabe, Y., and Kataoka, Y.:
    "Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles"
    Scientific Reports 6, 34990 (2016).
  • 9. Tamura, Y., Takahashi, K., Takata, K., Eguchi, A., Yamato, M., Kume, S., Nakano, M., Watanabe, Y., and Kataoka, Y.:
    "Noninvasive Evaluation of Cellular Proliferative Activity in Brain Neurogenic Regions in Rats under Depression and Treatment by Enhanced [18F] FLT-PET Imaging"
    Journal of Neuroscience 36(31), 8123-8131 (2016).
  • 10. Miyamoto, N., Maki, T., Shindo, A., Liang, A. C., Maeda, M., Egawa, N., Itoh, K., Lo, E. K., Lok, J., Ihara, M., and Arai1 K.:
    "Astrocytes promote oligodendrogenesis after white matter damage via brain-derived neurotrophic factor"
    Journal of Neuroscience 35, 14002-14008 (2015).

Lab Members

Principal investigator

Yosky Kataoka
Unit Leader

Core members

Yasuhisa Tamura
Senior Scientist
Norio Kobayashi
Senior Scientist
Masanori Yamato
Research Scientist
Asami Eguchi
Technical Staff I
Kumi Takata
Technical Staff I
Mitsuyo Maeda
Senior Visiting Scientist

Contact Information

MI R&D Building
6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047
Tel: +81-(0)78-304-7160
Fax: +81-(0)78-304-7161
Email: mayako.okamoto [at] riken.jp

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