Research Summary

Selected Publications

• 1.Sengoku, T., Suzuki, T., Dohmae, N., Watanabe, C., Honma, T., Hikida, Y., Yamaguchi, Y., Takahashi, H., Yokoyama, S. and Yanagisawa, T.:
  "Structural basis of protein arginine rhamnosylation by glycosyltransferase EarP"
  Nature Chemical Biology, 14, 368-374 (2018).
• 2.Hori, T., Okuno, T., Hirata, K., Yamashita, K., Kawano, Y., Yamamoto, M., Hato, M., Nakamura, M., Shimizu, T., Yokomizo, T., Miyano, M. and Yokoyama, S.:
  "Na⁺-mimicking ligands stabilize the inactive state of leukotriene B₄ receptor BLT1"
  Nature Chemical Biology, 14, 262-269 (2018).
• 3.Kashiwagi, K., Takahashi, M., Nishimoto, M., Hiyama, T. B., Higo, T., Umehara, T., Sakamoto, K., Ito, T. and Yokoyama, S.:
  "Crystal structure of eukaryotic translation initiation factor 2B"
  Nature, 531, 122-125 (2016).
• 4.Tanabe, H., Fujii, Y., Okada-Iwabu, M., Iwabu, M., Nakamura, Y., Hosaka, T., Motoyama, K., Ikeda, M., Wakiyama, M., Terada, T., Ohsawa, N., Hato, M., Ogasawara, S., Hino, T., Murata, T., Iwata, S., Hirata, K., Kawano, Y., Yamamoto, M., Kimura-Someya, T., Shirouzu, M., Yamauchi, T., Kadowaki, T. and Yokoyama, S.:
  "Crystal structures of the human adiponectin receptors"
  Nature, 520, 312-316 (2015).
• 5.Naganuma, M., Sekine, S., Chong, Y. E., Guo, M., Yang, X. L., Gamper, H., Hou, Y. M., Schimmel, P., and Yokoyama, S.:
  "The selective tRNA aminoacylation mechanism based on a single G・U pair."
  Nature, 510, 507-511 (2014).
• 6.Itoh, Y., Bröcker, M. J., Sekine, S., Hammond, G., Suetsugu, S., Söll, D. and and Yokoyama, S.:
  "Decameric SelA ・ tRNA^Sec ring structure reveals mechanism of bacterial selenocysteine formation"
  Science, 340, 75-78 (2013).
• 7.Tagami, S., Sekine, S., Kumarevel, T., Hino, N., Murayama, Y., Kamegamori, S., Yamamoto, M., Sakamoto, K. and Yokoyama, S.:
  "Crystal structure of bacterial RNA polymerase bound with a transcription inhibitor protein"
  Nature, 468, 978-982 (2010).
• 8.Ito, T. and Yokoyama, S.:
  "Two enzymes bound to one transfer RNA assume alternative conformations for consecutive reactions"
  Nature, 467, 612-616 (2010).
• 9.Shimada, A., Niwa, H., Tsujita, K., Suetsugu, S., Nitta, K., Hanawa-Suetsugu, K., Akasaka, R., Nishino, Y., Toyama, M., Chen, L., Liu, ZJ., Wang, BC., Yamamoto, M., Terada, T., Miyazawa, A., Tanaka, A., Sugano, S., Shirouzu, M., Nagayama, K., Takenawa, T. and Yokoyama, S.:
  "Curved EFC/F-BAR domain dimers are joined end to end into a filament for membrane invagination in endocytosis"
  Cell, 129, 761-772 (2007).
• 10.Sengoku, T., Nureki, O., Nakamura, A., Kobayashi, S. and Yokoyama, S.:
  "Structural basis for RNA unwinding by the DEAD-box protein Drosophila Vasa"
  Cell, 125, 287-300 (2006).

Recent Research Results

• 

  Apr. 27, 2018
  Structural insights into a protein-modification mechanism that boosts bacterial virulence

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