Research Summary

Selected Publications

• 1.Takata, A.*, Matsumoto, N., Kato, T.*:
  "Genome-wide identification of splicing QTLs in the human brain and their enrichment among schizophrenia-associated loci."
  Nature Communications 8: 14519 (2017). (* Co-corresponding authors)
• 2.Kasahara, T.#, Takata, A.#, Kato, T.M.#, Kubota-Sakashita, M., Sawada, T., Kakita, A., Mizukami, H., Kaneda, D., Ozawa, K., Kato, T.*:
  "Depression-like Episodes in Mice Harboring mtDNA Deletions in Paraventricular Thalamus."
  Molecular Psychiatry 21: 39-48 (2016). (# Co-first authors)
• 3.Kataoka, M.#, Matoba, N.#, Sawada, T., Kazuno, A.A., Ishiwata, M., Fujii, K., Matsuo, K., Takata, A.*, Kato, T.*:
  "Exome sequencing for bipolar disorder points to roles of de novo loss-of-function and protein-altering mutations."
  Molecular Psychiatry 21: 885-893 (2016). (# Co-first authors)
• 4.Hou, L., —— Kato, T. (112 of 123 authors), —— McMahon, F.J.*, Schulze, T.G.*:
  "Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study."
  Lancet 38: 1085-1093 (2016).
• 5.Bundo, M., Toyoshima, M., Okada, Y., Akamatsu, W., Ueda, J., Nemoto-Miyauchi, T., Sunaga, F., Toritsuka, M., Ikawa, D., Kakita, A., Kato, M., Kasai, K., Kishimoto, T., Nawa, H., Okano, H., Yoshikawa, T., Kato, T.*, Iwamoto, K.*:
  "Increased L1 retrotransposition in the neuronal genome in schizophrenia."
  Neuron, 81: 306-313 (2014). (* Co-corresponding authors)
• 6.Iwamoto, K,*, Bundo, M., Ueda, J., Oldham, M.C., Ukai, W., Hashimoto, E., Saito, T., Geschwind, D.H., Kato, T.*:
  "Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons."
  Genome Research 21: 688-696 (2011). (* Co-corresponding authors)
• 7.Kasahara, T.*, Abe, K., Mekada, K., Yoshiki, A., Kato, T.* :
  "Genetic variation of melatonin productivity in laboratory mice under domestication."
  Proceedings of the National Academy of Sciences of the United States of America 107: 6412-6417 (2010). (* Co-corresponding authors)
• 8.Kazuno, A., Munakata, K., Nagai, T., Shimozono, S., Tanaka, M., Yoneda, M., Kato, N., Miyawaki, A., Kato, T.*:
  "Identification of mitochondrial DNA polymorphisms that alter mitochondrial matrix pH and intracellular calcium dynamics."
  PLoS Genetics 2: e128 (2006).
• 9.Iwamoto, K., Bundo, M., and Kato, T.*:
  "Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis".
  Human Molecular Genetics, 14, 241-53 (2005).
• 10.Kakiuchi, C., Iwamoto, K., Ishiwata, M., Bundo, M., Kasahara, T., Kusumi, I., Tsujita, T., Okazaki, Y., Nanko, S., Kunugi, H., Sasaki, T., and Kato, T.*:
  "Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder"
  Nature Genetics, 35, 171-175 (2003).

Recent Research Results

• 

  Oct. 30, 2020
  Twin study of psychosis reveals developmental signaling deficit and imbalance of excitatory and inhibitory neurons

• 

  Jun. 11, 2018
  Mutation links bipolar disorder to mitochondrial disease

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