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RIKEN Center for Emergent Matter Science Emergent Bioengineering Materials Research Team

Team Leader: Yoshihiro Ito (D.Eng.)

Research Summary

Yoshihiro  Ito(D.Eng.)

Advanced materials composed of biological and artificial components are synthesized for development of environmentally friendly energy collection and conversion systems. By combination of organic synthetic chemistry, polymer chemistry, and biotechnology, novel material synthesis using biological and artificial elements, their chemical fabrication, and the characterization of the interfaces between biological and artificial elements for highly efficient energy collection and conversion are investigated.

Main Research Fields

  • Engineering

Related Research Fields

  • Complex Systems
  • Chemistry


  • Artificial Organ
  • Biosensor
  • Regenerative Medical Material
  • Biochip
  • Functional Polymeric Material

Selected Publications

  • 1.Nair, B.G., Zhou, Y., Hagiwara, K., Ueki, M., Isoshima, T., Abe, H. and Ito, Y.:
    "Enhancement of synergistic gene silencing by RNA interference using branched "3-in-1" trimer siRNA "
    J. Mater. Chem. B, 5, 4044-4051 (2017)
  • 2.Li, Z., He, P., Chong, H., Furube, A., Seki, K., Yu, H.-h., Tajima, K., Ito, Y. and Kawamoto, M.:
    "Direct aqueous dispersion of carbon nanotubes using nanoparticle-formed fullerenes and self-assembled formation of p/n heterojunctions with polythiophene"
    ACS Omega, 2, 1625-1632 (2017)
  • 3.Thoa, T. T. T., Minagawa, N., Aigaki, T., Ito, Y. and Uzawa, T.:
    "Regulation of photosensitisation processes by an RNA aptamer"
    Sci. Rep., 7, 43272 (2017)
  • 4.Salikolimi, K., Kawamoto, M., He, P., Aigaki, T. and Ito, Y.:
    "Polythiophene nanoparticles that display reversible multichromism in aqueous media"
    Polym. J., 49, 429-437 (2017)
  • 5.Mao, H., Kim, S. M., Ueki, M. and Ito, Y.:
    "Serum-free culturing of human mesenchymal stem cells with immobilized growth factors"
    J. Mater. Chem. B, 5, 928-934 (2017)
  • 6.Manandhar, Y., Wang, W., Inoue, J., Hayashi, N., Uzawa, T., Ito, Y., Aigaki, T. and Ito, Y.:
    "Interactions of in vitro selected fluorogenic peptide aptamers with calmodulin"
    Biotechnol. Lett., 39, 375-382 (2017)
  • 7.Wang, W., Zhu, L., Hirano, Y., Karamiavargani, M., Tada, S., Zhang, G., Uzawa, T., Zhang, D., Hirose, T., Taiji, M. and Ito, Y.:
    "Fluorogenic enhancement of in vitro selected binding peptide ligand by replacement of fluorescent group"
    Anal. Chem., 88, 7991-7997 (2016)
  • 8.Nair, B.G., Hagiwara, K., Ueda, M., Yu, H.-h., Tseng, H.-R., and Ito, Y.:
    "High density of aligned nanowire treated with polydopamine for efficient gene silencing by siRNA according to cell membrane perturbation"
    ACS Appl. Mater. Inter., 8, 18693-18700 (2016)
  • 9.Zhang, C., Miyatake, H., Wang, Y., Inaba, T., Wang, Y., Zhang, P. and Ito, Y.:
    "A bioorthogonal approach for the preparation of a titanium-binding insulin-like growth factor-1 derivative using tyrosinase"
    Angew. Chem. Int. Edn., 55, 11447-11451 (2016)
  • 10.Wang, W., Hirano, Y., Uzawa, T., Taiji, M. and Ito, Y.:
    "Assisted enhancement of inhibitory effects of small molecular inhibitors for kinases"
    Bull. Chem. Soc. Jpn., 89, 444-446 (2016)

Recent Research Results

Related Links

Lab Members

Principal investigator

Yoshihiro Ito
Team Leader

Core members

Masuki Kawamoto
Senior Research Scientist
Takanori Uzawa
Senior Research Scientist
Motoki Ueda
Research Scientist
Seiichi Tada
Research Scientist
Nandakumar Avanashiappan
Special Postdoctoral Researcher
Noriko Minagawa
Technical Staff I
Izumi Kono
Technical Staff I
Md.Mofizur Rahman
Junior Research Associate
Chinmay Ravindra Phadke
Junior Research Associate
Iljae Min
International Program Associate
Stefan Mueller
Student Trainee
Hsiu-Pen Lin
Student Trainee
So Jung Park
Student Trainee

Contact Information

501, Cooperation Center, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan
Tel: +81-(0)48-467-5809
Fax: +81-(0)48-467-9300
Email: y-ito [at] riken.jp