Chief Scientist Laboratories Bioengineering Laboratory
Chief Scientist: Mizuo Maeda (D.Eng.)
Research Summary
The principal purpose of the laboratory is to explore a new frontier of research field which fuses engineering and biological science. On the basis of polymer chemistry, analytical chemistry, surface chemistry, biochemistry and molecular biology, we are studying on new materials comprising biological components, novel methodology for bioanalysis and medical diagnosis, and artificial systems for regulation of biological processes. Those new ideas and materials are being applied to the field of biomaterials science, environmental science, micro/nanoscience, life science and medical engineering. For example, we newly prepared DNA-vinyl polymer conjugates which have been applied for DNA biosensor, affinity electrophoresis, SNPs-responsive diagnostic nanoparticle, gene-responsive hydrogel, artificial gene regulation system, etc. These researches may be classified into a new category, i.e., "DNA engineering".
Main Research Fields
- Chemistry
Related Research Fields
- Complex Systems
- Engineering
- Analytical chemistry
- Biomaterials science
- Macromolecular chemistry
Keywords
- nanoparticle
- DNA
- sensor
- bio conjugate
- bio macromolecule
Selected Publications
- 1.
Chuaychob, S., Thammakhet-Buranachai, C., Kanatharana, P., Thavarungkul, P., Buranachai, C., Fujita, M., and Maeda M.:
"A nanobiosensor for the simple detection of small molecules using non-crosslinking aggregation of gold nanoparticles with G-quadruplexes"
Anal. Methods, 12, 230-238 (2020). - 2.
Kato, S., Ozasa, K., Maeda, M., Tanno, Y., Tamaki, S., Higuchi-Takeuchi, M., Numata, K., Kodama, Y., Sato, M., Toyooka, K., and Shinomura, T.:
"Carotenoids are essential for light perception by the eyespot apparatus to initiate the phototactic movement of Euglena gracilis"
Plant J. 101, 1091-1102 (2020). - 3.
Sato, K., Hosokawa, K., and Maeda, M.:
"Characterizing the non-crosslinked aggregation of DNA-modified gold nanoparticles; effects of DNA length and terminal base pair"
Analyst, 144, 5580-5588, (2019). - 4.
Ozasa, K., Won, J., Song, S., Shinomura, T., and Maeda, M.:
"Phototaxis and photo-shock responses of Euglena gracilis under gravitaxis"
Algal Res., 41, 101563 (2019). - 5.
Kim, Y.-J., Hosokawa, K., and Maeda, M.:
"Sensitivity enhancement of microRNA detection using a power-free microfluidic chip"
Anal. Sci., 35, 1227-1236 (2019). - 6.
Yu, L., Shiraishi, S., Wang, G., Akiyama, Y., Takarada, T., and Maeda, M.:
"Connecting Nanoparticles with Different Colloidal Stability by DNA for Programmed Anisotropic Self-Assembly"
J. Phys. Chem. C, 123, 15293-15300 (2019). - 7.
Chang, C.-C., Wang, G., Takarada, T., and Maeda, M.:
"Target-Recycling-Amplified Colorimetric Detection of Pollen Allergen Using Non-Cross-Linking Aggregation of DNA-Modified Gold Nanoparticles"
ACS Sens., 4, 363-369 (2019). - 8.
Tang, Z., Takarada, T., and Maeda,M.:
"Non-Cross-Linking Aggregation of DNA-Carrying Polymer Micelles Triggered by Duplex Formation"
Langmuir, 34 (49), 14899-14910, (2018). - 9.
Wang, G., Akiyama, Y., Kanayama, N., Takarada, T., and Maeda, M.:
"Directed Assembly of Gold Nanorods by Terminal-Base Pairing of Surface-Grafted DNA"
Small, 1702137, (2017). - 10.
Hasegawa, K., Negishi, R., Matsumoto, M., Yohda, M., Hosokawa, K., and Maeda, M.:
"Specificity of microRNA detection on a power-free microfluidic chip with laminar flow-assisted dendritic amplification"
Anal. Sci., 33, 171-177 (2017).
Recent Research Results
Jul. 12, 2013
Fighting Alzheimer’s disease with protein origami
Publications
Annual research report
Related Links
Lab Members
Principal investigator
- Mizuo Maeda
- Chief Scientist
Core members
- Kazunari Ozasa
- Senior Research Scientist
- Tomohiro Hiraishi
- Senior Research Scientist
- Kazuo Hosokawa
- Senior Research Scientist
- Masahiro Fujita
- Senior Research Scientist
- Tohru Takarada
- Senior Research Scientist
- Rodtichoti Wannapob
- Postdoctoral Researcher
- Takafumi Sako
- Junior Research Associate
- Surachada Chuaychob
- International Program Associate
- Yoshifumi Sakamoto
- Student Trainee
- Masaya Inoue
- Student Trainee
- Michitsuna Tsutsumi
- Student Trainee
- Tamotsu Zako
- Senior Visiting Scientist
- Naoki Kanayama
- Visiting Scientist
- Makoto Takemasa
- Visiting Scientist
- Yoshitsugu Akiyama
- Visiting Scientist
- Guoqing Wang
- Visiting Scientist
- Ken-Ichi Wada
- Visiting Scientist
- Naoko Nakata
- Technical Staff II
- Masumi Furumoto
- Administrative Part-time Worker II
- Kumiko Matsumoto
- Administrative Part-time Worker II
- Akiko Nakamura
- Temporary Staffing
- Hiromi Ito
- Temporary Staffing
Contact Information
Cooperation Center
2-1 Hirosawa, Wako, Saitama
351-0198, Japan
Tel：+81-(0)48-462-9312
Tel：+81-(0)48-462-4658
Email: mizuo [at] riken.jp