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Chief Scientist Laboratories Elements Chemistry Laboratory

Chief Scientist: Masanobu Uchiyama (D.Phar.)

Research Summary

Masanobu  Uchiyama(D.Phar.)

Research in our laboratory spans the traditional areas of organic, inorganic and physical chemistry as well as interdisciplinary areas of modern chemical research, focusing in particular on the chemistry of elements (elements chemistry). We aim to better understand the reactions, properties, and structures of chemical substances not only by means of experimental approaches based on synthetic organic chemistry and spectroscopy, but also from a theoretical viewpoint based on computational chemistry. Our research interests include development of innovative chemical reactions, and design and synthesis of new functional molecules.

Main Research Fields

  • Chemistry

Related Research Fields

  • Medicine, Dentistry & Pharmacy
  • Chemical Pharmaceutical Science


  • Organic Chemistry
  • Synthetic Chemistry
  • Elements Chemistry
  • Theoretical Chemistry
  • Pharmaceutical Sciences

Selected Publications

  • 1.Toriumi, N., Asano, N., Ikeno, T., Muranaka, A., Hanaoka, K., Uranao, Y., and Uchiyama, M.:
    “Design of Photostable, Activatable Near-Infrared Photoacoustic Probes Using Tautomeric Benziphthalocyanine as a Platform”
    Angew. Chem. Int. Ed., in press.
  • 2.Okamoto, Y., Tanioka, M., Muranaka, A., Miyamoto, K., Aoyama, T., Ouyang, X., Kamino, S., Sawada, D., and Uchiyama, M.:
    “Stable Thiele’s Hydrocarbon Derivatives Exhibiting Near-Infrared Absorption/Emission and Two-Step Electrochromism”
    J. Am. Chem. Soc., 140, 17857-17861 (2018).
  • 3.Ribierre, J. C., Tanaka, T., Zhao, L., Yokota, Y., Matsumoto, S., Hashizume, D., Takaishi, K., Muto, T., Heinrich, B., Mery, S., Mathevet, F., Matsushima, T., Uchiyama, M., Adachi, C., and Aoyama, T.:
    “Simultaneous Edge-on to Face-on Reorientation and 1D Alignment of Small π-Conjugated Molecules Using Room-Temperature Mechanical Rubbing”
    Adv. Funct. Mater., 28, 1707038-1-12 (2018).
  • 4.Masumoto, Y., Toriumi, N., Muranaka, A., Kayahara, E., Yamago, S., and Uchiyama, M.:
    “Near-Infrared Fluorescence from In-Plane-Aromatic Cycloparaphenylene Dications”
    J. Phys. Chem. A, 122, 5162-5167 (2018).
  • 5.Toriumi, N., Yanagi, S., Muranaka, A., Hashizume, D., and Uchiyama, M.:
    "Effects of N-Oxidation on Heteroaromatic Macrocycles: Synthesis, Electronic Structures, Spectral Properties, and Reactivities of Tetraazaporphyrin meso-N-Oxides”
    Chem. Eur. J., 23, 8309-8314 (2017).
  • 6.Watanabe, S., Ohta, T., Urata, R., Sato, T., Takaishi, K., Uchiyama, M., Aoyama, T., and Kunitake, M.:
    “Quasi-Phase Diagrams at Air/Oil Interfaces and Bulk Oil Phases for Crystallization of Small-Molecular Semiconductors by Adjusting Gibbs Adsorption”
    Langmuir, 33, 8906-8913 (2017).
  • 7.Shirasaki, Y., Okamoto, Y., Muranaka, A., Kamino, S., Sawada, D., Hashizume, D., and Uchiyama, M.:
    “Fused-Fluoran Leuco Dyes with Large Color-Change Derived from Two-Step Equilibrium: iso-Aminobenzopyranoxanthenes”
    J. Org. Chem., 72, 8085-8090 (2016).
  • 8.Tanioka, M., Kamino, S., Muranaka, A., Ooyama, Y., Ota, H., Shirasaki, Y., Horigome, J., Ueda, M., Uchiyama, M., Sawada, D., and Enomoto, S.:
    “Reversible Near-Infrared/Blue Mechanofluorochromism of Aminobenzopyranoxanthene”
    J. Am. Chem. Soc., 137, 6436-6439 (2015).
  • 9.Ribierre, J. C., Zhao, L., Furukawa, S., Kikitsu, T., Inoue, D., Muranaka, A., Takaishi, K., Muto, T., Matsumoto, S., Hashizume, D., Uchiyama, M., Andre, P., Adachi, C., and Aoyama, T.:
    “Ambipolar Organic Field-Effect Transistors Based on Solution-Processed Single Crystal Microwires of a Quinoidal Oligothiophene Derivative”
    Chem. Commun., 51, 5836-5839 (2015).
  • 10.Toriumi, N., Muranaka, A., Kayahara, E., Yamago, S., and Uchiyama, M.:
    “In-Plane Aromaticity in Cycloparaphenylene Dications: A Magnetic Circular Dichroism and Theoretical Study”
    J. Am. Chem. Soc., 137, 82-85 (2015).

Recent Research Results

Annual research report

Lab Members

Principal investigator

Masanobu Uchiyama
Chief Scientist

Core members

Tetsuya Aoyama
Senior Research Scientist
Atsuya Muranaka
Senior Research Scientist
Yusuke Tanaka
Student Trainee
Mei Harada
Student Trainee
Tomotaka Murayama
Student Trainee
Ikumi Hanzawa
Student Trainee

Contact Information

2-1 Hirosawa, Wako, Saitama 351-0198, Japan
Email: uchi_yama [at] riken.jp