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Chief Scientist Laboratories Nano Medical Engineering Laboratory

Chief Scientist: Yoshihiro Ito (D.Eng.)

Research Summary

Yoshihiro  Ito(D.Eng.)

This laboratory aims to create new functional materials by a new method which will be developed by combination of chemical and biotechnological methodology. We use organic synthetic chemistry, combinatorial chemistry, molecular engineering, polymer engineering, hybrid materials engineering, gene and protein engineering, microfabrication technology, and nanotechnology to synthesize new materials and the systems for development of regenerative medicine, artificial organs, drug delivery systems, nanomedicine, molecular imaging, biochips, bioelectronics, artificial enzymes and artificial antibodies.

Main Research Fields

  • Complex Systems

Related Research Fields

  • Engineering
  • Bio-related chemistry
  • Molecular biology
  • Polymer chemistry


  • Artificial Organ Material
  • Biosensor
  • Regenerative Medicine Material
  • Biochip
  • Functional Polymeric Materials

Selected Publications

  • 1.Nair, B. G., Zhou, Y., Hagiwara, K., Ueki, M., Isoshima, T., Abe, H. and Ito, Y.:
    "Enhancement of synergistic gene silencing by RNA interference using branched “3-in-1”trimer siRNA"
    J. Mater. Chem. B, 5, 4044-4051 (2017)
  • 2.Maruyama, H., Oikawa, R., Hayakawa, M., Takamori, S., Kimura, Y., Abe, N., Tsuji, G., Akira Matsuda, A., Shuto, S., Ito, Y. and Abe, H.:
    "Chemical ligation of oligonucleotides using an electrophilic phosphorothioester"
    Nucleic Acid Res., 45, 7042-7048 (2017)
  • 3.Mao, H., Kim, S. M., Ueki, M. and Ito, T.:
    "Serum-free culturing of human mesenchymal stem cells with immobilized growth factors"
    J. Mater. Chem. B, 5, 928-934 (2017)
  • 4.Wang, W., Zhu, L., Hirano, Y., Karamiavargani, M., Tada, S., Zhang, G., Uzawa, T., Zhang, D., Hirose, T., Taiji, M. and Ito,Y.:
    "Fluorogenic enhancement of in vitro selected binding peptide ligand by replacement of fluorescent group"
    Anal. Chem., 88, 7991-7997 (2016)
  • 5.Nair B. G., Hagiwara, H., Ueda, M., Yu, H.-h., Tseng, H.-R. and Ito,Y.:
    "High density of aligned nanowire treated with polydopamine for efficient gene silencing by siRNA according to cell membrane perturbation"
    ACS Appl. Mater. Inter., 8, 18693-18700 (2016)
  • 6.Zhang, C., Miyatake, H., Wang, Y., Inaba, T., Wang, Y., Zhang, P. and Ito, Y.:
    "A bioorthogonal approach for the preparation of a titanium-binding insulin-like growth factor-1 derivative using tyrosinase"
    Angew. Chem. Int. Edn., 55, 11447-11451 (2016)
  • 7.Zhao, H., Jiang, G., Weng, J., Ma, Q., Zhang, H., Ito Y. and Liu, M.:
    "Signal-accumulating DNAzyme-crosslinked hydrogel for colorimetric sensing of hydrogen peroxide"
    J. Mater. Chem. B, 4, 4648-4651 (2016)
  • 8.Wang, W., Hirano, Y., Uzawa, T., Taiji, M. and Ito, Y.:
    "Assisted enhancement of inhibitory effects of small molecular inhibitors for kinases"
    Bull. Chem. Soc. Jpn., 89, 444-446 (2016)
  • 9.Wang, Z., Xu, Y., Wang, Y., Ito, Y., Zhang, P. and Chen, X.:
    "Enhanced in vitro mineralization and in vivo osteogenesis of composite scaffolds through controlled surface grafting of L-lactic acid oligomer on nano-hydroxyapatite"
    Biomacromolecules, 17, 818-829 (2016)
  • 10.Gisbergen, M. v., Cebula, M., Zhang, J., Ottosson-Wadlund, A., Dubois, L., Lambin, P., Tew, K., Townsend, D., Haenen, G., Drittij-Reijnders, M.-J., Saneyoshi, H., Araki, M., Shishido, Y., Ito, Y., Arner, E., Abe, H., Morgenstern, R. and Johansson, K.:
    "A chemical reactivity window determines prodrug efficiency towards glutathione transferase overexpressing cancer cells"
    Mol. Pharm., 13, 2010-2025 (2016)

Recent Research Results

Annual research report

Related Links

Lab Members

Principal investigator

Yoshihiro Ito
Chief Scientist

Core members

Takashi Isoshima
Senior Research Scientist
Hideyuki Miyatake
Senior Research Scientist
Masashi Ueki
Senior Research Scientist
Masuki Kawamoto
Senior Research Scientist
Takanori Uzawa
Senior Research Scientist
Motoki Ueda
Research Scientist
Yoko Aida
Research Scientist
Hirotaka Sato
Research Scientist
Nobuhiro Morishima
Special Temporary Research Scientist
Jun Akimoto
Special Postdoctoral Researcher
0 Liushiqi
Postdoctoral Researcher
Lanlan Bai
Visiting Researcher
Lowela Libunao Siarot
Postdoctoral Researcher
Seong Min Kim
Junior Research Associate
Eunhye Kim
Junior Research Associate
Roopa Dharmatti
International Program Associate
Marziyeh Karimiavargani
Student Trainee
Hao Chang
Student Trainee
Wlaa Assi
Student Trainee
Tomoya Hirose
Student Trainee
Minori Ichikawa
Student Trainee
Boyang Ning
Student Trainee

Contact Information

2-1 Hirosawa, Wako, Saitama 351-0198, Japan

Email: y-ito [at] riken.jp