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Chief Scientist Laboratories Nano Medical Engineering Laboratory

Chief Scientist: Yoshihiro Ito (D.Eng.)

Research Summary

Yoshihiro  Ito(D.Eng.)

This laboratory aims to create new functional materials by a new method which will be developed by combination of chemical and biotechnological methodology. We use organic synthetic chemistry, combinatorial chemistry, molecular engineering, polymer engineering, hybrid materials engineering, gene and protein engineering, microfabrication technology, and nanotechnology to synthesize new materials and the systems for development of regenerative medicine, artificial organs, drug delivery systems, nanomedicine, molecular imaging, biochips, bioelectronics, artificial enzymes and artificial antibodies.

Main Research Fields

  • Complex Systems

Related Research Fields

  • Engineering
  • Bio-related chemistry
  • Molecular biology
  • Polymer chemistry


  • Artificial Organ Material
  • Biosensor
  • Regenerative Medicine Material
  • Biochip
  • Functional Polymeric Materials

Selected Publications

  • 1. Chin, M., Tada, S., Tsai, M.-H., Ito, Y., and Luo, S.-C.:
    "Strategy to Immobilize Peptide Probe Selected through in Vitro Ribosome Display for Electrochemical Aptasensor Application"
    Anal. Chem., 92, 11260–11267 (2020)
  • 2. Son, K., Ueda, M., Taguchi, K., Maruyama, T., Takeoka, S., and Ito, Y.:
    "Evasion of the Accelerated Blood Clearance Phenomenon by Polysarcosine Coating of Liposomes"
    J. Control. Rel., 322, 209-216 (2020)
  • 3. Kimura, Y., Shu, Z., Ito, M., Abe, N., Nakamoto, K., Tomoike, F., Shuto, S., Ito, Y., and Abe, H.:
    "Intracellular build-up RNAi with single-strand circular RNAs as siRNA precursor"
    Chem. Commun., 56, 466-469 (2020)
  • 4. Mueller, S., Ueda, M., Isoshima, T., Ushida, T., and Ito, Y.:
    "Stretching of fibroblast cells on micropatterned gelatin on silicone elastomer"
    J. Mater. Chem. B, 8, 416-425 (2020)
  • 5. Rahman, M. M., Ueda, M., Son, K., Seo, S., Takeoka, S., Hirose, T., and Ito, Y.:
    "Tubular network formation by mixing amphiphilic polypeptides with differing hydrophilic blocks"
    Biomacromolecules, 20, 3908-3914 (2019)
  • 6. Kim, S. M., Wada, K.-I., Ueki, M., Hosokawa, K., Maeda, M., Sakai, Y., and Ito, Y.:
    "Cytoplasmic fusion between an enlarged embryonic stem cell and a somatic cell using a microtunnel device"
    Biochem. Biophys. Res. Commun., 520, 257-262 (2019)
  • 7. Ren, X., Akimoto, J., Miyatake, H., Tada, S., Zhu, L., Mao, H., Isoshima, T., Mueller, S., Kim, S. M., Zhou, Y., and Ito, Y.:
    "Cell migration and growth induced by photo-immobilised vascular endothelial growth factor (VEGF) isoforms"
    J. Mater. Chem. B, 7, 4272-4279 (2019)
  • 8. Shu, Z., Tanka, I., Ota, A., Fushihara, D., Abe, N., Kawaguchi, S., Nakamoto, K., Tomoike, F., Tada, S., Ito, Y., Kimura, Y., and Abe, H.:
    "Disulfide-unit conjugation enables ultrafast cytosolic internalization of antisense DNA and siRNA",
    Angew. Chem. Int. Edn., 58, 6611-6615 (2019)
  • 9. Iyoda, T., Yamasaki, S., Kawamura, M., Ueda, M., Son, K., Ito, Y., Shimizu, K., and Fujii, S.-i.:
    "Optimal therapeutic strategy using antigen-containing liposomes selectively delivered to antigen-presenting cells"
    Cancer Sci., 110, 875-887 (2019)
  • 10. Ueda, M., Seo, S., Nair, B., Mueller, S., Takahashi, E., Arai, T., Iyoda, T., Fujii, S.-i., Tsuneda, S., and Ito, Y.:
    "End-Sealed High Aspect Ratio Hollow Nanotube Encapsulating Anticancer Drug - Torpedo-Shaped Peptidic Nanocapsule"
    ACS Nano, 13, 305-312 (2019)

Recent Research Results

Annual research report

Related Links

Lab Members

Principal investigator

Yoshihiro Ito
Chief Scientist

Core members

Takashi Isoshima
Senior Research Scientist
Hideyuki Miyatake
Senior Research Scientist
Masuki Kawamoto
Senior Research Scientist
Takanori Uzawa
Senior Research Scientist
Motoki Ueda
Senior Research Scientist
Nandakumar Avanashiappan
Research Scientist
Hei Man Leung
Special Postdoctoral Researcher
Mohammed Abdelhamid ramadan Abosheasha
Postdoctoral Researcher
Eunhye Kim
Visiting Researcher
Mohamed Said Ramadan Elafify
International Program Associate
Kun Fang
International Program Associate
Shin Woong Kim
Student Trainee
Jie Tang
Student Trainee
Kuan Yang
Student Trainee
Shigeru Uchiyama
Technical Staff I

Contact Information

2-1 Hirosawa, Wako, Saitama 351-0198, Japan
Email: y-ito [at] riken.jp