Chief Scientist Laboratories Nano Medical Engineering Laboratory

Chief Scientist: Yoshihiro Ito (D.Eng.)

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Research Summary

This laboratory aims to create new functional materials by a new method which will be developed by combination of chemical and biotechnological methodology. We use organic synthetic chemistry, combinatorial chemistry, molecular engineering, polymer engineering, hybrid materials engineering, gene and protein engineering, microfabrication technology, and nanotechnology to synthesize new materials and the systems for development of regenerative medicine, artificial organs, drug delivery systems, nanomedicine, molecular imaging, biochips, bioelectronics, artificial enzymes and artificial antibodies.

Main Research Fields

Complex Systems

Related Research Fields

Engineering
Bio-related chemistry
Molecular biology
Polymer chemistry

Keywords

Artificial Organ Material
Biosensor
Regenerative Medicine Material
Biochip
Functional Polymeric Materials

Selected Publications

1. Chin, M., Tada, S., Tsai, M.-H., Ito, Y., and Luo, S.-C.:
"Strategy to Immobilize Peptide Probe Selected through in Vitro Ribosome Display for Electrochemical Aptasensor Application"
Anal. Chem., 92, 11260–11267 (2020)
2. Son, K., Ueda, M., Taguchi, K., Maruyama, T., Takeoka, S., and Ito, Y.:
"Evasion of the Accelerated Blood Clearance Phenomenon by Polysarcosine Coating of Liposomes"
J. Control. Rel., 322, 209-216 (2020)
3. Kimura, Y., Shu, Z., Ito, M., Abe, N., Nakamoto, K., Tomoike, F., Shuto, S., Ito, Y., and Abe, H.:
"Intracellular build-up RNAi with single-strand circular RNAs as siRNA precursor"
Chem. Commun., 56, 466-469 (2020)
4. Mueller, S., Ueda, M., Isoshima, T., Ushida, T., and Ito, Y.:
"Stretching of fibroblast cells on micropatterned gelatin on silicone elastomer"
J. Mater. Chem. B, 8, 416-425 (2020)
5. Rahman, M. M., Ueda, M., Son, K., Seo, S., Takeoka, S., Hirose, T., and Ito, Y.:
"Tubular network formation by mixing amphiphilic polypeptides with differing hydrophilic blocks"
Biomacromolecules, 20, 3908-3914 (2019)
6. Kim, S. M., Wada, K.-I., Ueki, M., Hosokawa, K., Maeda, M., Sakai, Y., and Ito, Y.:
"Cytoplasmic fusion between an enlarged embryonic stem cell and a somatic cell using a microtunnel device"
Biochem. Biophys. Res. Commun., 520, 257-262 (2019)
7. Ren, X., Akimoto, J., Miyatake, H., Tada, S., Zhu, L., Mao, H., Isoshima, T., Mueller, S., Kim, S. M., Zhou, Y., and Ito, Y.:
"Cell migration and growth induced by photo-immobilised vascular endothelial growth factor (VEGF) isoforms"
J. Mater. Chem. B, 7, 4272-4279 (2019)
8. Shu, Z., Tanka, I., Ota, A., Fushihara, D., Abe, N., Kawaguchi, S., Nakamoto, K., Tomoike, F., Tada, S., Ito, Y., Kimura, Y., and Abe, H.:
"Disulfide-unit conjugation enables ultrafast cytosolic internalization of antisense DNA and siRNA",
Angew. Chem. Int. Edn., 58, 6611-6615 (2019)
9. Iyoda, T., Yamasaki, S., Kawamura, M., Ueda, M., Son, K., Ito, Y., Shimizu, K., and Fujii, S.-i.:
"Optimal therapeutic strategy using antigen-containing liposomes selectively delivered to antigen-presenting cells"
Cancer Sci., 110, 875-887 (2019)
10. Ueda, M., Seo, S., Nair, B., Mueller, S., Takahashi, E., Arai, T., Iyoda, T., Fujii, S.-i., Tsuneda, S., and Ito, Y.:
"End-Sealed High Aspect Ratio Hollow Nanotube Encapsulating Anticancer Drug - Torpedo-Shaped Peptidic Nanocapsule"
ACS Nano, 13, 305-312 (2019)