RIKEN Center for Sustainable Resource Science Chemical Biology Research Group
Group Director: Hiroyuki Osada (D.Agr.)
Research Summary

To promote "Chemical Biological Research" that aims to elucidate biological phenomena using chemical compounds as starting materials, chemical libraries.
Our group constructs chemical libraries through the genetic engineering of microorganisms and organic synthesis, and databases that describe the chemical and biological information of the libraries.
We explore the useful bioactive compounds in the chemical library and identify the molecular targets of bioactive compounds, and elucidate the mechanisms behind the actions of the active compounds as well.
We continue to maintain the infrastructure for advanced studies of chemical biology and sustainable resource science.
Main Research Fields
- Complex Systems
Related Research Fields
- Interdisciplinary Science & Engineering
- Biology
Keywords
- Chemical Biology
- Natural Products Depository
- Chembioinformatics
- Isolation and Synthesis of Bioactive Compounds
- Analysis of Protein-Small Molecule Interaction
Selected Publications
- 1.Otaka, J., Hashizume, D., Masumoto, Y., Muranaka, A., Uchiyama, M., Koshino, H., Futamura, Y., and Osada, H.:
"Hitoyol A and B, Two Norsesquiterpenoids from the Basidiomycete Coprinopsis cinerea."
Org Lett. [Epub ahead of print] (2017). - 2.Nogawa, T., Okano, A., Lim, C.L., Futamura, Y., Shimizu, T., Takahashi, S., Ibrahim, D., and Osada H.:
"Opantimycin A, a new metabolite isolated from Streptomyces sp. RK88-1355."
J Antibiot, 70, 222-225 (2017). - 3.Kawatani, M., Muroi, M., Wada, A., Inoue, G., Futamura, Y., Aono, H., Shimizu, K., Shimizu, T., Igarashi, Y., Takahashi-Ando, N., and Osada, H.:
"Proteomic profiling reveals that collismycin A is an iron chelator"
Sci Rep, 6, 38385 (2016). - 4.Hasebe, F., Matsuda, K., Shiraishi, T., Futamura, Y., Nakano, T., Tomita, T., Ishigami, K., Taka, H., Mineki, R., Fujimura, T., Osada, H., Kuzuyama, T., and Nishiyama, T.:
"Amino group carrier protein-mediated secondary metabolite biosynthesis in Streptomyces"
Nat Chem Biol, 12, 967–972 (2016). - 5.Kondoh, Y., Honda, K., Hiranuma, S., Hayashi, T., Shimizu, T., Watanabe, N., and Osada, H.:
"Comparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ."
Sci Rep, 6, 29881 (2016). - 6.Yun C.S., Motoyama T., and Osada H.:
"Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme"
Nat. Commun. 6, 8758 (2015). - 7.Soeda Y., Yoshikawa M., Almeida O.F., Sumioka A., Maeda S., Osada H., Kondoh Y., Saito A., Miyasaka T., Kimura T., Suzuki M., Koyama H., Yoshiike Y., Sugimoto H., Ihara Y., and Takashima A.:
"Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups"
Nat. Commun. 6, 10216 (2015). - 8.Kawamura T., Kondoh Y., Muroi M., Kawatani M.,and Osada H.:
"A small molecule that induces reactive oxygen species via cellular glutathione depletion"
Biochem. J. 463, 53-63 (2014). - 9.Futamura Y., Kawatani M., Muroi M., Aono H., Nogawa T., and Osada H.:
"Identification of a molecular target of a novel fungal metabolite, pyrrolizilactone, by phenotypic profiling systems"
ChemBioChem 14, 2456-2463 (2013). - 10.Motoyama T., Hayashi T., Hirota H., Ueki M., and Osada H.:
"Terpendole E, a kinesin Eg5 inhibitor, is a key biosynthetic intermediate of indole-diterpenes in the producing fungus Chaunopycnis alba"
Chem. Biol., 19, 1611-1619 (2012).
Recent Research Results
Oct. 27, 2015
Secrets of a rice-killing fungal toxin
Related Links
Lab Members
Principal investigator
- Hiroyuki Osada
- Group Director
Core members
- Makoto Muroi
- Senior Research Scientist
- Takayuki Motoyama
- Senior Research Scientist
- Yasumitsu Kondoh
- Senior Research Scientist
- Makoto Kawatani
- Senior Research Scientist
- Toshihiko Nogawa
- Research Scientist
- Yushi Futamura
- Research Scientist
- Choong Soo Yun
- Research Scientist
- Kazuko Yoshida
- Postdoctoral Researcher
- Julius Lopez
- Postdoctoral Researcher
- Xiaoying Sun
- Postdoctoral Researcher
- Hiromasa Yoshioka
- Postdoctoral Researcher
- Yuuki Furuyama
- Junior Research Associate
- Mira Syahfriena Binti Amir Rawa
- International Program Associate
- Fauze Bin Mahmud
- International Program Associate
- Harumi Aono
- Technical Staff I
- Akiko Okano
- Technical Staff I
- Kaori Honda
- Technical Staff I
- Motoko Uchida
- Technical Staff I
- Naoko Ogawa
- Technical Staff I
- Rachael Uson Lopez
- Technical Staff I
- Emiko Sanada
- Technical Staff I
Contact Information
Chemical Biology Building,
2-1 Hirosawa, Wako, Saitama
351-0198, Japan
Tel: +81-(0)48-467-9541
Fax: +81-(0)48-462-4669
Email: hisyo [at] riken.jp