RIKEN Center for Sustainable Resource Science Chemical Biology Research Group

Group Director: Hiroyuki Osada (D.Agr.)

Japanese Page

Research Summary

To promote "Chemical Biological Research" that aims to elucidate biological phenomena using chemical compounds as starting materials, chemical libraries.

Our group constructs chemical libraries through the genetic engineering of microorganisms and organic synthesis, and databases that describe the chemical and biological information of the libraries.

We explore the useful bioactive compounds in the chemical library and identify the molecular targets of bioactive compounds, and elucidate the mechanisms behind the actions of the active compounds as well.

We continue to maintain the infrastructure for advanced studies of chemical biology and sustainable resource science.

Main Research Fields

Complex Systems

Related Research Fields

Interdisciplinary Science & Engineering
Biology

Keywords

Chemical Biology
Natural Products Depository
Chembioinformatics
Isolation and Synthesis of Bioactive Compounds
Analysis of Protein-Small Molecule Interaction

Selected Publications

1.Otaka, J., Hashizume, D., Masumoto, Y., Muranaka, A., Uchiyama, M., Koshino, H., Futamura, Y., and Osada, H.:
"Hitoyol A and B, Two Norsesquiterpenoids from the Basidiomycete Coprinopsis cinerea."
Org Lett. [Epub ahead of print] (2017).
2.Nogawa, T., Okano, A., Lim, C.L., Futamura, Y., Shimizu, T., Takahashi, S., Ibrahim, D., and Osada H.:
"Opantimycin A, a new metabolite isolated from Streptomyces sp. RK88-1355."
J Antibiot, 70, 222-225 (2017).
3.Kawatani, M., Muroi, M., Wada, A., Inoue, G., Futamura, Y., Aono, H., Shimizu, K., Shimizu, T., Igarashi, Y., Takahashi-Ando, N., and Osada, H.:
"Proteomic profiling reveals that collismycin A is an iron chelator"
Sci Rep, 6, 38385 (2016).
4.Hasebe, F., Matsuda, K., Shiraishi, T., Futamura, Y., Nakano, T., Tomita, T., Ishigami, K., Taka, H., Mineki, R., Fujimura, T., Osada, H., Kuzuyama, T., and Nishiyama, T.:
"Amino group carrier protein-mediated secondary metabolite biosynthesis in Streptomyces"
Nat Chem Biol, 12, 967–972 (2016).
5.Kondoh, Y., Honda, K., Hiranuma, S., Hayashi, T., Shimizu, T., Watanabe, N., and Osada, H.:
"Comparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ."
Sci Rep, 6, 29881 (2016).
6.Yun C.S., Motoyama T., and Osada H.:
"Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme"
Nat. Commun. 6, 8758 (2015).
7.Soeda Y., Yoshikawa M., Almeida O.F., Sumioka A., Maeda S., Osada H., Kondoh Y., Saito A., Miyasaka T., Kimura T., Suzuki M., Koyama H., Yoshiike Y., Sugimoto H., Ihara Y., and Takashima A.:
"Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups"
Nat. Commun. 6, 10216 (2015).
8.Kawamura T., Kondoh Y., Muroi M., Kawatani M.,and Osada H.:
"A small molecule that induces reactive oxygen species via cellular glutathione depletion"
Biochem. J. 463, 53-63 (2014).
9.Futamura Y., Kawatani M., Muroi M., Aono H., Nogawa T., and Osada H.:
"Identification of a molecular target of a novel fungal metabolite, pyrrolizilactone, by phenotypic profiling systems"
ChemBioChem 14, 2456-2463 (2013).
10.Motoyama T., Hayashi T., Hirota H., Ueki M., and Osada H.:
"Terpendole E, a kinesin Eg5 inhibitor, is a key biosynthetic intermediate of indole-diterpenes in the producing fungus Chaunopycnis alba"
Chem. Biol., 19, 1611-1619 (2012).