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RIKEN Center for Sustainable Resource Science Bioprobe Research Group

Group Director: Hiroyuki Osada (D.Agr.)

Research Summary

Hiroyuki  Osada(D.Agr.)

In collaboration with a group of Max Planck Institute (MPI) of Molecular Physiology (group of Prof. Herbert Waldmann), Dortmund, Germany, we perform chemical biology study. We exchange young researchers each other for the tight and continuous collaboration.

Main Research Fields

  • Complex Systems

Related Research Fields

  • Interdisciplinary Science & Engineering
  • Biological Sciences


  • Chemical Biology
  • Natural Products Depository
  • Analysis of Protein-Small Molecule Interaction

Selected Publications

  • 1.Robke, L., Laraia, L., Carnero Corrales, M.A., Konstantinidis, G., Muroi, M., Richters, A., Winzker, M., Engbring, T., Tomassi, S., Watanabe, N., Osada, H., Rauh, D., Waldmann, H., Wu, Y.W., and Engel, J.:
    "Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34."
    Angew Chem Int Ed Engl. 56, 8153-8157 (2017).
  • 2.Ursu, A., Illich, D.J., Takemoto, Y., Porfetye, A.T., Zhang M., Brockmeyer, A, Janning, P., Watanabe, N., Osada, H., Vetter, I.R., Ziegler, S., Schöler, H.R., and Waldmann, H.:
    "Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1."
    Cell Chem Biol. 23, 494-507 (2016).
  • 3.Kawatani M, Muroi M, Wada A, Inoue G, Futamura Y, Aono H, Shimizu K, Shimizu T, Igarashi Y, Takahashi-Ando N, Osada H.:
    "Proteomic profiling reveals that collismycin A is an iron chelator."
    Sci Rep, 6, 38385 (2016).
  • 4.Kawamura T, Kawatani M, Muroi M, Kondoh Y, Futamura Y, Aono H, Tanaka M, Honda K, Osada H.:
    "Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival."
    Sci Rep, 6, 26521 (2016).
  • 5.Muroi M, Futamura Y, Osada H.:
    "Integrated profiling methods for identifying the targets of bioactive compounds: MorphoBase and ChemProteoBase."
    Nat Prod Rep, 33, 621-625 (2016).
  • 6.Kawamura T, Kondoh Y, Muroi M, Kawatani M, Osada H.:
    "A small molecule that induces reactive oxygen species via cellular glutathione depletion."
    Biochem J, 463, 53-63 (2014).

Related Links

Lab Members

Principal investigator

Hiroyuki Osada
Group Director

Core members

Makoto Muroi
Senior Research Scientist

Contact Information

Chemical Biology Building,
2-1 Hirosawa,
Wako, Saitama
351-0198, Japan

Email: hisyo [at] riken.jp