Research Summary

Selected Publications

• 1.Robke, L., Laraia, L., Carnero Corrales, M.A., Konstantinidis, G., Muroi, M., Richters, A., Winzker, M., Engbring, T., Tomassi, S., Watanabe, N., Osada, H., Rauh, D., Waldmann, H., Wu, Y.W., and Engel, J.:
  "Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34."
  Angew Chem Int Ed Engl. 56, 8153-8157 (2017).
• 2.Ursu, A., Illich, D.J., Takemoto, Y., Porfetye, A.T., Zhang M., Brockmeyer, A, Janning, P., Watanabe, N., Osada, H., Vetter, I.R., Ziegler, S., Schöler, H.R., and Waldmann, H.:
  "Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1."
  Cell Chem Biol. 23, 494-507 (2016).
• 3.Kawatani M, Muroi M, Wada A, Inoue G, Futamura Y, Aono H, Shimizu K, Shimizu T, Igarashi Y, Takahashi-Ando N, Osada H.:
  "Proteomic profiling reveals that collismycin A is an iron chelator."
  Sci Rep, 6, 38385 (2016).
• 4.Kawamura T, Kawatani M, Muroi M, Kondoh Y, Futamura Y, Aono H, Tanaka M, Honda K, Osada H.:
  "Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival."
  Sci Rep, 6, 26521 (2016).
• 5.Muroi M, Futamura Y, Osada H.:
  "Integrated profiling methods for identifying the targets of bioactive compounds: MorphoBase and ChemProteoBase."
  Nat Prod Rep, 33, 621-625 (2016).
• 6.Kawamura T, Kondoh Y, Muroi M, Kawatani M, Osada H.:
  "A small molecule that induces reactive oxygen species via cellular glutathione depletion."
  Biochem J, 463, 53-63 (2014).

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