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RIKEN Center for Integrative Medical Sciences Laboratory for Cell Signaling

Team Leader: Takashi Saito (Ph.D.)

Research Summary

Takashi  Saito

The general goal of this laboratory is to elucidate the mechanism of activation, differentiation and function, and its regulation of T cells which play central roles in the regulation of immune responses and homeostasis. These include the regulation of immunological synapse, T cell receptor-induced signal transduction, co-stimulation regulation and signaling in T cell development. Particularly, the mechanism to induce autoimmune diseases and inflammations caused by aberrant regulation of T cell function and activation will be analyzed to aim to overcome the diseases.

Main Research Fields

  • Medicine, Dentistry & Pharmacy

Related Research Fields

  • Biology


  • T lymphocyte
  • lymphocyte activation
  • Immune regulation
  • Immunological synapse
  • autoimmunity

Selected Publications

  • 1.Hashimoto-Tane, A., Sakuma, M., Ike, H., Yokosuka, T., Kimura, Y., Ohara, O. and Saito, T.:
    "Micro adhesion-ring surrounding TCR microclusters are essential for T cell activation."
    J. Exp. Med. 213:1609-1625 (2016).
  • 2.Takeuchi, A., Badr, M.E.S.G., Miyauchi, K., Ishihara C., Onishi R., Guo Z., Sasaki, T., Ike H., Takumi, A., Tsuji N.M., Murakami, Y., Katakai, T. and Saito, T.:
    "CRTAM determines the CD4+ cytotoxic T lymphocyte lineage."
    J. Exp.Med. 213:123-138 (2016).
  • 3.Hara, H., Yokosuka, T., Hirakawa, H., Ishihara, C., Yasukawa, S., Yamazaki, M., Koseki, H., Yoshida, H. and Saito, T. :
    "Clustering of CARMA1 through SH3-GUK domain interactions is required for its activation of NF-kB signaling."
    Nat. Commun. 6:5555 (2015).
  • 4.Imanishi, T., Ishihara C., El Sherif Badr, M., Kimura Y, Kawai, T., Takeuchi, O., Taniguchi, S-I., Noda, T., Hirano, H., Brombacher, F., Barber, G., Akira, S. and Saito, T.:
    "Nucleic acid sensing by T cells initiates Th2 cell differentiation."
    Nat.Commun.5:3566 (2014).
  • 5.Tsukumo, S., Unno, M., Muto, A., Takeuchi, A., Kometani, K., Kurosaki, T., Igarashi, K. and Saito, T.:
    "Bach2 maintains T cells in naïve state by suppressing effector memory-related genes."
    Proc.Natl.Acad.Sci. 110: 10735-10740 (2013).
  • 6.Yokosuka, T., Takamatsu, M., Kobayashi-Imanishi, W., Hashimoto-Tane, A., Azuma, M. and Saito, T.:
    "Programmed cell death-1 forms negative costimulatory microclusters that directly inhibit T cell receptor signals by recruitment of phosphatase SHP2."
    J. Exp. Med. 209:1201-1217 (2012)
  • 7.Hashimoto-Tane, A., Yokosuka, T., Sakata-Sogawa, K., Sakuma, M., Ishihara, C., Tokunaga, M. and Saito, T.:
    "Dynein-driven transport of T cell receptor microclusters regulates immune synapse and T cell activation."
    Immunity 34:919-931 (2011).
  • 8.Yokosuka T., Kobayashi, W., Takamatsu, Sakata-Sogawa, K., Zang, H., Hashimoto-Tane, A., M., Yagita, H., Tokunaga, M. and Saito, T.:
    "Spatiotemporal basis of CTLA4-mediated negative regulation of T-cell activation."
    Immunity 33:326-339 (2010).
  • 9.Yamasaki, S., Ishikawa, E., Sakuma, M., Ogata, K. and Saito, T.:
    "Mincle is an ITAM-coupled activating receptor that senses damaged cells."
    Nat. Immunol. 9: 1179-1188 (2008).
  • 10.Yokosuka, T., Kobayashi, W., Sakata-Sogawa, K., Hashimoto-Tane, A., Dustin, M.L., Tokunaga, M. and Saito, T.:
    "Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters through protein kinase C θ translocation."
    Immunity. 29: 589-601 (2008).

Recent Research Results

Related Links

Lab Members

Principal investigator

Takashi Saito
Team Leader

Core members

Takayuki Imanishi
Senior Research Scientist
Natsuko Tanimura
Research Scientist
Machie Sakuma
Technical Staff I
Midori Unno
Technical Staff I
Noriko Yoza
Expert Technician
Natsumi Yoneda
Technical Staff II

Contact Information

1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-7037
Fax: +81-(0)45-503-7036
Email: takashi.saito [at] riken.jp