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RIKEN Center for Integrative Medical Sciences Laboratory for Cell Signaling

Team Leader: Takashi Saito (Ph.D.)

Research Summary

Takashi  Saito(Ph.D.)

The general goal of this laboratory is to elucidate the mechanism of activation, differentiation and function, and its regulation of T cells which play central roles in the regulation of immune responses and homeostasis. These include the regulation of immunological synapse, T cell receptor-induced signal transduction, co-stimulation regulation and signaling in T cell development. Particularly, the mechanism to induce autoimmune diseases and inflammations caused by aberrant regulation of T cell function and activation will be analyzed to aim to overcome the diseases.

Main Research Fields

  • Medicine, Dentistry & Pharmacy

Related Research Fields

  • Biology


  • T lymphocyte
  • lymphocyte activation
  • Immune regulation
  • Immunological synapse
  • autoimmunity

Selected Publications

  • 1.Hashimoto-Tane, A., Sakuma, M., Ike, H., Yokosuka, T., Kimura, Y., Ohara, O. and Saito, T.:
    "Micro adhesion-ring surrounding TCR microclusters are essential for T cell activation."
    J. Exp. Med. 213:1609-1625 (2016).
  • 2.Takeuchi, A., Badr, M.E.S.G., Miyauchi, K., Ishihara C., Onishi R., Guo Z., Sasaki, T., Ike H., Takumi, A., Tsuji N.M., Murakami, Y., Katakai, T. and Saito, T.:
    "CRTAM determines the CD4+ cytotoxic T lymphocyte lineage."
    J. Exp.Med. 213:123-138 (2016).
  • 3.Hara, H., Yokosuka, T., Hirakawa, H., Ishihara, C., Yasukawa, S., Yamazaki, M., Koseki, H., Yoshida, H. and Saito, T. :
    "Clustering of CARMA1 through SH3-GUK domain interactions is required for its activation of NF-kB signaling."
    Nat. Commun. 6:5555 (2015).
  • 4.Imanishi, T., Ishihara C., El Sherif Badr, M., Kimura Y, Kawai, T., Takeuchi, O., Taniguchi, S-I., Noda, T., Hirano, H., Brombacher, F., Barber, G., Akira, S. and Saito, T.:
    "Nucleic acid sensing by T cells initiates Th2 cell differentiation."
    Nat.Commun.5:3566 (2014).
  • 5.Tsukumo, S., Unno, M., Muto, A., Takeuchi, A., Kometani, K., Kurosaki, T., Igarashi, K. and Saito, T.:
    "Bach2 maintains T cells in naïve state by suppressing effector memory-related genes."
    Proc.Natl.Acad.Sci. 110: 10735-10740 (2013).
  • 6.Yokosuka, T., Takamatsu, M., Kobayashi-Imanishi, W., Hashimoto-Tane, A., Azuma, M. and Saito, T.:
    "Programmed cell death-1 forms negative costimulatory microclusters that directly inhibit T cell receptor signals by recruitment of phosphatase SHP2."
    J. Exp. Med. 209:1201-1217 (2012)
  • 7.Hashimoto-Tane, A., Yokosuka, T., Sakata-Sogawa, K., Sakuma, M., Ishihara, C., Tokunaga, M. and Saito, T.:
    "Dynein-driven transport of T cell receptor microclusters regulates immune synapse and T cell activation."
    Immunity 34:919-931 (2011).
  • 8.Yokosuka T., Kobayashi, W., Takamatsu, Sakata-Sogawa, K., Zang, H., Hashimoto-Tane, A., M., Yagita, H., Tokunaga, M. and Saito, T.:
    "Spatiotemporal basis of CTLA4-mediated negative regulation of T-cell activation."
    Immunity 33:326-339 (2010).
  • 9.Yamasaki, S., Ishikawa, E., Sakuma, M., Ogata, K. and Saito, T.:
    "Mincle is an ITAM-coupled activating receptor that senses damaged cells."
    Nat. Immunol. 9: 1179-1188 (2008).
  • 10.Yokosuka, T., Kobayashi, W., Sakata-Sogawa, K., Hashimoto-Tane, A., Dustin, M.L., Tokunaga, M. and Saito, T.:
    "Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters through protein kinase C θ translocation."
    Immunity. 29: 589-601 (2008).

Recent Research Results

Related Links

Lab Members

Principal investigator

Takashi Saito
Team Leader

Core members

Akiko Tane
Senior Research Scientist
Takayuki Imanishi
Research Scientist
Noel Verjan Garcia
Research Associate
Machie Sakuma
Technical Staff I
Midori Unno
Technical Staff I
Noriko Yoza
Technical Staff I
Akihiro Ishiyama
Technical Staff I
Natsumi Yoneda
Technical Staff II

Contact Information

1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-7037
Fax: +81-(0)45-503-7036
Email: takashi.saito [at] riken.jp